Results 71 to 80 of about 807,608 (297)

Relationship between vascular calcification, osteoporosis and systemic inflammation

Сибирский научный медицинский журнал
A lot of patients with coronary heart disease often suffer from vascular calcification. In many cases it is accompanied by harmful cardiovascular events.
K. A. Nichiporuk, S. Yu. Tsarenok, V. V. Gorbunov, N. A. Ilyamakova, T. A. Aksenova   +4 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

VASCULAR CALCIFICATION: FROM INNOCENT BYSTANDER TO CULPRIT RISK FACTOR

Artery Research, 2017
Vascular calcification was regarded as an innocent bystander in cardiovascular disease. It was considered to be the passive chemical nucleation of calcium and phosphate ions on cellular debris and therefore the end-stage of atherosclerosis.
Leon J. Schurgers
doaj   +1 more source

Vascular calcification in chronic kidney disease: an update

, 2016
Cardiovascular calcification is both a risk factor and contributor to morbidity and mortality. Patients with chronic kidney disease (and/or diabetes) exhibit accelerated calcification of the intima, media, heart valves and likely the myocardium as well ...
Schurgers, Leon; id_orcid, Schurgers, Leon, Reutelingsperger, Christiaan, Reutelingsperger, Chris, Flöge, Jürgen, Brandenburg, Vincent, Schlieper, Georg, Brandenburg, Vincent Matthias, Floege, Juergen   +8 more
core   +1 more source

Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification [PDF]

, 2016
Vascular calcification powerfully predicts mortality and morbidity from cardiovascular disease. Men have a greater risk of cardiovascular disease, compared to women of a similar age.
Wu, Junxi, Zhu, Dongxing, Dweck, Marc R., Newby, David E., MacRae, Vicky E, Lerman, Daniel A., Dweck, Marc R, Newby, David E, Vesey, Alex T, MacRae, Vicky E., Vesey, Alex T., Lerman, Daniel A, Hadoke, Patrick W. F., Smith, Lee B, Hadoke, Patrick WF, Smith, Lee B., Hadoke, Patrick W.F.   +16 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Vascular MSCs govern the atherosclerotic plaque calcification under inflammatory conditions

, 2019
Introduction. The vascular calcification, recruiting osteo-progenitors under inflammatory stimulation, recapitulates the normal bone-biogenesis process. We recently identified a population of Mesenchymal Stem Cells (MSCs) within abdominal aortic aneurysm
Pasquinelli G, Gallitto E, Ciavarella C, Sonetto A, Abhualin M, Faggioli GL, Gargiulo M   +6 more
core   +1 more source

Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients

Kidney & Blood Pressure Research, 2018
Background/Aims: Vascular calcification, which involves an active cellular transformation of vascular smooth muscle cells into bone forming cells, is prevalent and predicts mortality in dialysis patients. Its mechanisms are complex and unclear.
Lian He, Wan-Yu He, La-Ta A, Wen-Ling Yang, Ai-Hua Zhang   +4 more
doaj   +1 more source

The chemistry of thiosulfate and vascular calcification [PDF]

Nephrology Dialysis Transplantation, 2011
Thiosulfate has been shown to inhibit vascular calcification in uremic rats and may inhibit calcification in humans with end-stage renal disease but whether this is due to a systemic or local action is unknown. The underlying mechanism is also unclear but complexation of calcium ions has been proposed.In vitro assays were used to determine the effect ...
W Charles, O'Neill, Kenneth I, Hardcastle   +1 more
openaire   +2 more sources

MicroRNAs Regulate Vascular Medial Calcification [PDF]

, 2014
Vascular calcification is highly prevalent in patients with coronary artery disease and, when present, is associated with major adverse cardiovascular events, including an increased risk of cardiovascular mortality.
Jane Leopold, Leopold, Jane, Jane A. Leopold   +2 more
core   +1 more source