Results 81 to 90 of about 807,608 (297)

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Considerations on the Development of Therapeutics in Vascular Calcification

Journal of Cardiovascular Development and Disease
Cardiovascular disease is the leading cause of death worldwide. Vascular calcification, the deposition of calcium phosphate mineral in the arterial wall, is the most significant predictor of morbidity and mortality.
Ana M. Valentin Cabrera, Sophie K. Ashbrook, Joshua D. Hutcheson   +2 more
doaj   +1 more source

Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone

Frontiers in Physiology, 2018
Vascular calcification is the deposition of calcium phosphate minerals in vascular tissue. Vascular calcification occurs by both active and passive processes.
Mary C. Wallingford, Mary C. Wallingford, Ciara Benson, Nicholas W. Chavkin, Nicholas W. Chavkin, Michael T. Chin, Martin G. Frasch   +6 more
doaj   +1 more source

Vascular Calcification [PDF]

Journal of the American Society of Nephrology, 2009
Vascular calcification, primarily arterial calcification, is one of multiple forms of extraskeletal calcification that is highly prevalent in patients with chronic kidney disease (CKD), especially those on dialysis. Arterial calcification is not a new or novel phenomenon: Mummified bodies from the ice age and many older adults and patients with ...
openaire   +1 more source

The leading edge of vascular calcification [PDF]

Trends in Cardiovascular Medicine, 2015
About two decades ago, when lipids were the focus of atherosclerosis research, calcific vasculopathy (or, more commonly, “vascular calcification”) had been dismissed as a non-biological, unregulated, degenerative phenomenon. Ironically, decades earlier, atherosclerosis itself had been dismissed in the same manner.
Demer, Linda L, Tintut, Yin
openaire   +5 more sources

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification : a role for GRP (Gla-rich protein) [PDF]

, 2018
Objective: Inhibition of mineral crystal formation is a crucial step in ectopic calcification. Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) calcification propensity, but additional knowledge is required to ...
Viegas, Carla SB, Carla S.B. Viegas, Schurgers, Leon, Macedo, Anjos L, Anjos L. Macedo, Rute Morais, Pedro L. Neves, Viegas, Carla S. B., Macedo, Anjos L., Ana P. Silva, Staes, An, Cees Vermeer, Lúcia Santos, Silva, Ana P, Neves, Pedro L, Vermeer, Cees, António A. Matos, Leon Schurgers, Morais, Rute, Silva, Ana P., Simes, Dina C., Dina C. Simes, Neves, Pedro L., An Staes, Matos, António A, Kris Gevaert, Schurgers, Leon; id_orcid, Santos, Lúcia, Simes, Dina C, Gevaert, Kris, Matos, Antonio A.   +30 more
core   +2 more sources

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

AKT-independent activation of p38 MAP kinase promotes vascular calcification

Redox Biology, 2018
Vascular calcification is prevalent in patients with atherosclerosis, and oxidative stress promotes pathogenesis of atherosclerosis. We have previously reported that activation of AKT by oxidative stress induces vascular calcification.
Youfeng Yang, Yong Sun, Jianye Chen, Wayne E. Bradley, Louis J. Dell’Italia, Hui Wu, Yabing Chen   +6 more
doaj   +1 more source

Key role for VSMCs in vascular remodeling and calcification [PDF]

, 2020
This research shows that cardiovascular diseases, such as vascular calcification and thrombosis, should be addressed and treated differently. Instead of the regular treatment of symptoms (i.e.
Jaminon, Armand Mario Gerard
core   +5 more sources