Results 81 to 90 of about 20,356 (286)

Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis [PDF]

, 2016
__Background/objectives__ Carotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The validity of this assumption for IMT is challenged by recent meta-analyses; for CCS by absence of a ...
Bogaerdt, A. (Antoon) van den, Bogers, A.J.J.C. (Ad), Hamming, J.F. (Jaap), Lindeman, J. (J.), Meershoek, A. (Armelle), Schaapherder, A.F.M. (Alexander), van Dijk, R.A. (Rogier A.), Verhage, S. (Sander)   +7 more
core   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Minimally Invasive Mitral Valve Surgery I: Patient Selection, Evaluation, and Planning. [PDF]

, 2016
Widespread adoption of minimally invasive mitral valve repair and replacement may be fostered by practice consensus and standardization. This expert opinion, first of a 3-part series, outlines current best practices in patient evaluation and selection ...
Agnihotri, Arvind K, Ailawadi, Gorav, Barnhart, Glenn R, Farivar, R Saeid, Fayers, Trevor M, Goldman, Scott M, Grossi, Eugene A, Guy, T Sloane, Hargrove, W Clark, Hummel, Brian W, Khan, Junaid H, Lehr, Eric J, Lewis, Clifton TP, Malaisrie, S Chris, Mehall, John R, Murphy, Douglas A, Rodriguez, Evelio, Ryan, William H, Salemi, Arash, Segurola, Romualdo J, Shemin, Richard J, Smith, J Michael, Smith, Robert L, Weldner, Paul W, Wolfe, J Alan   +24 more
core   +1 more source

Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio, Martina Caiazza, Emanuele Monda, Giustina Aruta, Alberto Budillon, Augusto Esposito, Adelaide Fusco, Annapaola Cirillo, Marta Rubino, Immacolata Viscovo, Gioacchino Scarano, Matteo Della Monica, Vincenzo Nigro, Giulio Piluso, Leandro Pecchia, Maria Giovanna Russo, Giuseppe Limongelli   +16 more
wiley   +1 more source

Macrophage‐targeted cerium‐tannic acid metal‐polyphenol framework nanoenzyme promotes in situ heart valves regeneration through adaptive immunomodulation

BMEMat, EarlyView.
A novel nanoenzyme based on cerium ions‐tannic acid metal‐polyphenol framework (FCT) has been developed and loaded onto DHVs for targeting M1 macrophages to reduce their ROS level and reprogram macrophage phenotype, thereby eliminating inflammation, promoting endothelialization and adaptive matrix remodeling of scaffolds, offering a promising strategy ...
Peng Song, Yunlong Wu, Xing Chen, Yafei Liu, Mengna Dong, Jiawei Shi, Xichi Wang, Nianguo Dong, Weihua Qiao, Qin Wang   +9 more
wiley   +1 more source

Investigating the Relationship between Calcium Score in Coronary Arteries and Aortic Valve in Predicting the Risk of Cardiovascular Events on Cardiac Computed Tomography Angiography [PDF]

پزشکی بالینی ابن سینا
Background and Objective: Coronary artery and aortic valve calcium measurement is a low-cost, fast, and without the need for injection of contrast media, which is important in determining the severity of atherosclerosis and the prognosis of heart disease.
Seyed Kamaledin Hadei, Mina Azhand, Farnaz Fariba   +2 more
doaj  

Deep learning based automatic quantification of aortic valve calcification on contrast enhanced coronary CT angiography

Scientific Reports
Quantifying aortic valve calcification is critical for assessing the severity of aortic stenosis, predicting cardiovascular risk, and guiding treatment decisions.
Daebeom Park, Soon-Sung Kwon, Yoona Song, Yoon A Kim, Baren Jeong, Whal Lee, Eun-Ah Park   +6 more
doaj   +1 more source

Importance of Imaging Assessment Criteria in Predicting the Need for Post-Dilatation in Transcatheter Aortic Valve Implantation with a Self-Expanding Bioprosthesis

Journal of Cardiovascular Development and Disease
Background: Transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic valve stenosis (AS). Balloon post-dilatation (PD) remains an important procedural step to optimize valve function by resolving incomplete valve ...
Matthias Hammerer, Philipp Hasenbichler, Nikolaos Schörghofer, Christoph Knapitsch, Nikolaus Clodi, Uta C. Hoppe, Klaus Hergan, Elke Boxhammer, Bernhard Scharinger   +8 more
doaj   +1 more source

New adverse coronary events in valve-in-valve TAVR and native TAVR—A 2-year matched cohort

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo assess the incidence of new adverse coronary events (NACE) following transcatheter aortic valve replacement (TAVR) and valve-in-valve TAVR (ViV-TAVR).BackgroundViV-TAVR is an accepted treatment for degenerative prostheses among patients with ...
Ofir Koren, Ofir Koren, Vivek Patel, Robert Naami, Edmund Naami, Takashi Nagasaka, Takashi Nagasaka, Alon Shechter, Alon Shechter, Sharon Shalom Natanzon, Siamak Kohan, Zev Allison, Addee Lerner, Daniel Eugene Cheng, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Hasan Jilaihawi, Raj R. Makkar   +18 more
doaj   +1 more source