Results 111 to 120 of about 62,879 (264)

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source

Frailty and Five‐Year Mortality After TAVR in Patients Aged 75 Years and Older

Journal of the American Geriatrics Society, EarlyView.
In patients aged 75 years and older undergoing transcatheter aortic valve replacement, frailty assessed by the Clinical Frailty Scale was the most robust geriatric factor independently associated with five‐year mortality. This study highlights the specific prognostic value of frailty beyond short‐term outcomes.
Jérémie Huet, Mélissa Sabin, Thierry Le Tourneau, Thibaut Manigold, Anne‐Sophie Boureau   +4 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Association Between Sleep Quality and Oxidative Stress in Postoperative Cardiovascular Patients—A Pilot Study

Journal of Sleep Research, EarlyView.
In 15 postoperative cardiac surgery patients, venous reactive oxygen species (ROS) measured by electron spin resonance (ESR) over 48 h showed no consistent circadian pattern. Higher ROS was associated with lower subjective sleep efficiency and more nocturnal awakenings, but not with other sleep measures.
K. Krawczyk, D. Riemann, E. Schleicher, A. Günther, A. Ayekoi, M. Czerny, J. S. Pooth, T. Böhmerle, B. Feige, J. Sahlmann, F. Beyersdorf   +10 more
wiley   +1 more source

PFA Under Deep Sedation and Non‐Invasive Monitoring in Atrial Fibrillation Patients With Obstructive Sleep Apnea

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Clinical data about pulsed field ablation (PFA) under deep sedation among patients with obstructive sleep apnea (OSA) are limited, while the optimal periprocedural monitoring is not established. We report our experience in PFA among patients with atrial fibrillation (AF) and OSA, using a continuous non‐invasive respiratory and ...
Dionyssios Leftheriotis, Konstantinos A. Papathanasiou, Efstratios Karamanolis, Areti Vlachodiamanti, Evangelia Stamatopoulou, Maria Polikandrioti, Panagiota Flevari   +6 more
wiley   +1 more source

Leadless Pacemaker Implantation in High‐Risk Patients: Real‐World Outcomes From a Multicenter Israeli Registry

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Transvenous pacemakers are effective but carry significant short‐ and long‐term complications. Leadless pacemakers were developed to overcome these limitations, however, data in high‐risk patients ineligible for transvenous systems remain limited.
Moshe Katz, Marianna Vander, David Luria, Moshe Rav Acha, Yoav Michowitz, Alon Barsheshet, Gregory Golovchiner, Roy Beinart   +7 more
wiley   +1 more source

Ventricular Synchrony in Targeted Right Ventricular Septal Pacing: A Prospective Paired Comparison to Apical Placement

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background/Objectives Right ventricular (RV) apical pacing, the standard pacing approach, often induces ventricular dyssynchrony, potentially impairing cardiac function. This study aims to investigate whether targeted RV septal pacing, guided by functional electrophysiological feedback during implantation, reduces ventricular dyssynchrony ...
Bianca Iulia Catrina, Mihai Octavian Negrea, Ciprian Tănăsescu, Florina Batar, Florin‐Leontin Lazar, Ioan Manitiu   +5 more
wiley   +1 more source

Haemodynamic responses to head‐up tilt versus lower‐body negative pressure in type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Head‐up tilt (HUT) and lower‐body negative pressure (LBNP) both reduce central blood volume but differ in heart orientation and regional fluid shifts. Whether they evoke comparable cardiovascular regulation when matched for preload remains uncertain.
Victorien Faivre‐Rampant, Jules Warnier, Perrine Larmet, Damien Garcia, Michael Joubert, Damian Miles Bailey, Igor Mekjavic, Hervé Normand, Amir Hodzic   +8 more
wiley   +1 more source