Results 241 to 250 of about 873,650 (292)

Association Between Cardiovascular Diseases and Lingual Varices: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
El Kanfoud-Ezzarraa A, Egido-Moreno S, Mantinyan-Hakobyan A, Hinarejos MB, González-Navarro B, Oliveras Serrano A, Otero-Rey E, López-López J.   +7 more
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Clinicopathologic Characteristics of Somatic <i>TP53</i> Mutations in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Systematic Review. [PDF]

EJHaem
Aldapt M, Kaddoura R, Saleh AO, Najim M, Salem A, Al-Mashdali AF, Muthanna B, Aweer RA, Rabadi M, Mohamed SF.   +9 more
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Morphology-Aware Peptide Discovery via Masked Conditional Generative Modeling. [PDF]

ACS Nano
Costa N, Zavadlav J.
europepmc   +1 more source

Malaria Vaccine Rollout in Nigeria: Current Status and Challenges. [PDF]

Am J Trop Med Hyg
Oyegbade SA, Adeboye SO, Oni GJ, Oyegbade AP, Oziohu JJ, Duyann ZY, Owoyemi OC.   +6 more
europepmc   +1 more source

National Surveillance of Enterovirus D68 Upsurge, France, 2024. [PDF]

Emerg Infect Dis
Jeannoël M, Bisseux M, Dan S, Creuzet E, Parraud D, Bailly JL, Lebeurre J, Brebion A, Chabrolles H, Josset L, Henquell C, Schuffenecker I, Mirand A, Enterovirus Surveillance Network.   +13 more
europepmc   +1 more source

Long-term cultivation shifts transcriptomic profile of HCT-116 cells. [PDF]

MicroPubl Biol
Marquardt G, Wießner-Kroh T, Rubner S, Papasotiriou I.   +3 more
europepmc   +1 more source

The effects of time-restricted feeding on early phases of carcinogenesis in rat liver and colon. [PDF]

Front Nutr
Malakmahmoudi N, Pisu R, Barbarossa A, Pisu F, Porcu GS, Laconi E, Perra A, Uzzau S, Marongiu F.   +8 more
europepmc   +1 more source