Results 101 to 110 of about 158,301 (286)
Optical communication with semiconductor laser diodes [PDF]
A 25 megabit/sec direct detection optical communication system that used Q=4 PPM signalling was constructed and its performance measured under laboratory conditions.
Davidson, F.
core +2 more sources
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu +8 more
wiley +1 more source
The Scientific World Journal, 2012 Objectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods.
Cheng-Hao Weng +9 more
doaj +1 more source
, 2017 A main challenge of today's organizations is the monitoring of their processes to check whether these processes comply with process models specifying the prescribed behavior. Deviations from the prescribed behavior can represent either legitimate work practices not described by the models, which highlight the need of improving it to better reflect the ...
Genga, L. +4 more
openaire +1 more source
, 2021 A screening tool to examine common psycho social outcomes of auditory processing problems with clients who seek counselling on personal and interpersonal ...
openaire +1 more source
Advanced Science, EarlyView.A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang +17 more
wiley +1 more source
, 2019 The infrared detector is the most important component within any radiation thermometry based system, with its choice determining the wavelength, response time and, ultimately, the temperature measurement capabilities of the instrument. To improve upon the existing generation of radiation thermometers, more sensitive detector technologies are required ...
Hobbs, M., Willmott, J.R.
openaire
Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, EarlyView.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source