Results 101 to 110 of about 49,952 (301)

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Pengaruh Tipe Kepribadian, Pengawasan, Kebijakan dan Manajemen APD Terhadap Kepatuhan Penggunaan APD Pada Pekerja di PT DOK dan Perkapalan Surabaya [PDF]

, 2020
Kewajiban tenaga kerja pada saat bekerja adalah patuh menggunakan APD secara tepat. Dampak yang akan terjadi apabila pekerja tidak menggunakan APD meliputi bahaya yang mengakibatkan cidera pada kepala dan kaki apabila kejatuhan benda berat, cidera mata ...
Bella Oktavia
core   +1 more source

Downscaled operational oceanographic system for coastal waters of Korea using a wave-current coupled model

, 2012
We have developed a downscaled operational oceanographic system for the coastal waters of Korea using a wave-current coupled model. The operational modeling system comprises of coastal circulation model ROMS coupled with wave model SWAN, inter-nally ...
심재설, 임학수, 김창식, 박광순, 전인식   +4 more
core  

A New Ordered Transformation‐Induced Plasticity Enables Exceptional Strength and Ductility in a B2 Medium‐Entropy Alloy

Advanced Science, EarlyView.
A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li, Yidong Wu, Boyuan Zheng, Xu Zhang, Xiongjun Liu, Wenli Song, Ning An, Chengbo Xiao, Xidong Hui   +8 more
wiley   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

Advanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran, Fangchi Shao, Gregory Datto, Tathansh Joshi, Elizabeth Chatt, Yashar Bashirzadeh, Dan Stessman, Lai Wei, Kuangwen Hsieh, Hena Guo, Tza‐Huei Wang   +10 more
wiley   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

SHOT ENHANCEMENT AND THERMAL NOISE APD PIN X APD

Jurnal Informatika dan Teknik Elektro Terapan
DalamperangkatoptiksepertiAPD,PIN,danPMT,terdapattrade-offantaraGain,Q-factor,danBER.PeningkatanGaindapatmenurunkanQ-factordanmeningkatkanBER. Perubahandayalasermemengaruhikualitassinyal,denganpeningkatandayameningkatkan Q-factordanmengurangiBER,namunjugameningkatkannoisedankonsumsidaya.Gain APD atau PIN mempengaruhi sensitivitas deteksidan kualitas ...
openaire   +2 more sources

Hubungan Karakteristik Individu, Safety Sign, Kondisi APD, dan Pengawasan dengan Penggunaan APD Depo Lokomotif Semarang Poncol [PDF]

Latar belakang: Pekerja bagian pemeriksaan dan perawatan Depo Lokomotif Semarang Poncol memilki potensi bahaya tinggi karena pada pekerjaannya dituntut untuk berinteraksi langsung dengan sumber bahaya yaitu lokomotif.
Gardinia, Genoveva, Wahyuni, Ida, Setyaningsih, Yuliani   +2 more
core   +1 more source