Results 201 to 210 of about 49,952 (301)

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Ventricular arrhythmogenesis in pulmonary hypertension: From right ventricular remodeling to clinical implications. [PDF]

Physiol Rep
Kiris A, Zhang P, Bronk P, Choi BR, Choudhary G.   +4 more
europepmc   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

A dual-ion/immune checkpoint nanoplatform-activated pyroptosis/cGAS-STING signaling transform iMWA into systemic immunotherapy against HCC recurrence. [PDF]

Mater Today Bio
Zhang M, Rong C, Qin H, Qin X, Jiang Z, Qiu G, Qin T, Qin G, Zhou N, Tang W, Su D, Huang Y, Zhao C.   +12 more
europepmc   +1 more source

The multicellular environment of the re‐entrant circuit in post‐myocardial infarction ventricular tachycardia: Beyond fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat, Jaffar Al‐Sheikhli, Andrew M. Blanks, Joseph Mayer, Nicolas Lellouche, Tarvinder Dhanjal, Christopher O'Shea   +6 more
wiley   +1 more source

Tripterine Liposome Exerts Antitumor and Immunomodulatory Effects in Pancreatic Ductal Adenocarcinoma. [PDF]

MedComm (2020)
Tang L, Lin Y, Jiang X, Tian X, Battaglia G, Wei Y, Wu W, He X, Wei X.   +8 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Ionic Disorders in Persistent Atrial Fibrillation: Therapeutic Targeting by Plant-Derived Bioactive Compounds. [PDF]

Cardiol Res Pract
Zhai Y, Shi N, Duan W, Yang J.
europepmc   +1 more source

Extracellular ionic concentration modulates arrhythmias in a simulated population of human ventricular myocytes with long QT syndrome type 3

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustrating the in silico study pipeline. A total of 50,000 virtual myocytes were generated, which were then filtered to 7093 myocytes that fit experimentally constrained biomarkers for physiological electrical and calcium behaviour under wild‐type conditions.
Katherine Flannery, Jacob A. Miller, Steven Poelzing, Seth H. Weinberg   +3 more
wiley   +1 more source

Correction: Auditory Processing Disorder in childhood: a critical appraisal of diagnostic validity, functional assessment, and interdisciplinary practice. [PDF]

Front Hum Neurosci
Dos Santos JCC, Arruda MA, Masruha MR.
europepmc   +1 more source