Results 71 to 80 of about 5,186 (188)

An Artificial Intelligence System for Staging the Spheno‐Occipital Synchondrosis

Orthodontics &Craniofacial Research, Volume 28, Issue 6, Page 998-1007, December 2025.
ABSTRACT Objective The aim of this study was to develop, test and validate automated interpretable deep learning algorithms for the assessment and classification of the spheno‐occipital synchondrosis (SOS) fusion stages from a cone beam computed tomography (CBCT).
Omid Halimi Milani, Lauren Mills, Amanda Nikho, Marouane Tliba, Halil Ayyildiz, Veerasathpurush Allareddy, Rashid Ansari, Ahmet Enis Cetin, Mohammed H. Elnagar   +8 more
wiley   +1 more source

FGF/FGFR signaling coordinates skull development by modulating magnitude of morphological integration: evidence from Apert syndrome mouse models. [PDF]

PLoS ONE, 2011
The fibroblast growth factor and receptor system (FGF/FGFR) mediates cell communication and pattern formation in many tissue types (e.g., osseous, nervous, vascular).
Neus Martínez-Abadías, Yann Heuzé, Yingli Wang, Ethylin Wang Jabs, Kristina Aldridge, Joan T Richtsmeier   +5 more
doaj   +1 more source

Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers. [PDF]

, 2016
PurposeWe present a case of bilateral extensive peripapillary myelinated retinal nerve fibers (MRNF) in an individual with Crouzon syndrome, an inherited form of craniosynostosis caused by overactivation of fibroblast growth factor receptor 2.
Akil, Handan, Apinyawasisuk, Supanut, Garcia, Giancarlo A, Kim, Sarah, Sadun, Alfredo A, Tian, Jack J   +5 more
core   +3 more sources

A Longitudinal Cone Beam Computed Tomography Study of Mandibular Canal Changes During Growth

Orthodontics &Craniofacial Research, Volume 28, Issue 6, Page 1008-1014, December 2025.
ABSTRACT Introduction The mandibular canal has been considered a stable anatomic reference structure and continues to be recognised as a primary vertical structure in 2D mandibular superimposition. However, whether the mandibular canal is stable in the transverse dimension is unclear.
Stephanie H. Chen, Normand Boucher, Chun‐Hsi Chung, Chenshuang Li   +3 more
wiley   +1 more source

A deletion of FGFR2 creating a chimeric IIIb/IIIc exon in a child with Apert syndrome

BMC Medical Genetics, 2011
Background Signalling by fibroblast growth factor receptor type 2 (FGFR2) normally involves a tissue-specific alternative splice choice between two exons (IIIb and IIIc), which generates two receptor isoforms (FGFR2b and FGFR2c respectively) with ...
Klatt Regan EM, Bowdin Sarah C, Fenwick Aimee L, Wilkie Andrew OM   +3 more
doaj   +1 more source

Gingival enlargement following levetiracetam treatment: A clinical case analysis

Epilepsia Open, Volume 10, Issue 5, Page 1695-1698, October 2025.
Abstract This report describes a 21‐year‐old female with a history of epilepsy, diagnosed at age 17, who developed gingival enlargement after being treated with levetiracetam. Her dosage was titrated to 750 mg twice daily, achieving satisfactory seizure control.
Awadh M. Alahmari, Ali M. Alkhathaami
wiley   +1 more source

Surface-bounded growth modeling applied to human mandibles [PDF]

, 2000
From a set of longitudinal three-dimensional scans of the same anatomical structure, we have accurately modeled the temporal shape and size changes using a linear shape model.
Bjarne K. Ersbøll, Bjarne Kjær Ersbøll, Fred L. Bookstein, Human Mandibles, Jeffrey L. Marsh, Knut Conradsen, Per R. Andresen, Per Rønsholt Andresen, Sven Kreiborg   +8 more
core   +3 more sources

Biallelic FGF4 Variants Linked to Thoracic Dystrophy and Respiratory Insufficiency

Clinical Genetics, Volume 108, Issue 4, Page 479-485, October 2025.
We report three people from two unrelated families with a clinical diagnosis of thoracic dystrophy characterized by short or missing ribs, narrow chest, and respiratory insufficiency. Affected people each have rare, biallelic, predicted deleterious missense substitutions in FGF4, a gene known to be essential for the formation of the thoracic skeleton ...
Laura M. Watts, Esther Kinning, Donald R. Latner, Marla Johnston, Jessica Patrick‐Esteve, Gregory M. Cooper, Stephen R. F. Twigg, Alistair T. Pagnamenta, Jenny C. Taylor   +8 more
wiley   +1 more source

Classification of Subtypes of Apert Syndrome, Based on the Type of Vault Suture Synostosis

Plastic and Reconstructive Surgery, Global Open, 2019
Background:. Apert syndrome patients are different in clinical pathology, including obstructive sleep apnea, cleft palate, and mental deficiency. These functional deficiencies may be due to anatomic deformities, which may be caused by different forms of ...
Xiaona Lu, MD, Rajendra Sawh-Martinez, MD, MHS, Antonio Jorge Forte, MD, Robin Wu, BS, Raysa Cabrejo, BS, Alexander Wilson, BS, Derek M. Steinbacher, MD, DMD, Michael Alperovich, MD, Nivaldo Alonso, MD, PhD, John A. Persing, MD   +9 more
doaj   +1 more source

Apert's syndrome.

Indian journal of dermatology, venereology and leprology, 2007
Apert's syndrome (acrocephalosyndactyly) is a rare congenital disorder characterized by craniosynostosis, mid-facial malformations and symmetrical syndactyly. We present a 2-month-old girl having features of Apert's syndrome, with cerebral cortical atrophy and bifurcation of the right first metatarsal base, a hitherto undescribed finding.
Amiya Kumar Mukhopadhyay, Debjani Mukherjee   +1 more
openaire   +1 more source