Results 51 to 60 of about 15,964 (182)

Longitudinal Videofluorographic Dysphagia Measures in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dysphagia can lead to fatal aspiration pneumonia in progressive supranuclear palsy (PSP). Little is known about the longitudinal progression of dysphagia or whether it differs across PSP clinical variants. Objectives To characterize longitudinal changes in dysphagia across PSP variants and determine relationships with disease ...
Anna Chiara Cattani, Jerusha G. Bhaskaran, Farwa Ali, Julie Stierwalt, Federica Agosta, Massimo Filippi, Keith A. Josephs, Heather M. Clark, Jennifer L. Whitwell   +8 more
wiley   +1 more source

Treatment of Primary Progressive Aphasia [PDF]

Current Treatment Options in Neurology, 2015
Primary progressive aphasia (PPA) is a neurodegenerative disease that primarily affects language functions and often begins in the fifth or sixth decade of life. The devastating effects on work and home life call for the investigation of treatment alternatives.
Donna C, Tippett, Argye E, Hillis, Kyrana, Tsapkini   +2 more
openaire   +2 more sources

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Associations between TMEM106B C‐terminal fragment aggregation, age, and TDP‐43 or tau pathology

Brain Pathology, EarlyView.
TMEM106B C‐terminal fragment (CTF) aggregation represents an age‐associated, common, diffuse phenomenon emerging after midlife with a weak association with TDP‐43 or tau pathology. These findings suggest that TMEM106B fibrillization may define a distinct axis of protein aggregation in the aging human brain. Abstract Transmembrane protein 106B (TMEM106B)
Albert Acewicz, Sylwia Tarka, Michał Grzegorczyk, Radosław Rzepliński, Teresa Wierzba‐Bobrowicz, Tomasz Stępień   +5 more
wiley   +1 more source

Care Needs for Patients Screened Positive for Cognitive Impairment and Delirium: A Cross‐Sectional Observational Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To describe the point prevalence of cognitive impairment in hospitalised adults and evaluate the association with care needs and perceived risks of complications. Design Multi‐site cross‐sectional study on a single day in May 2023. Methods Trained clinician auditors screened adult inpatients in acute medical, surgical, oncology, geriatric,
Alison M. Mudge, Sarah Anderson, Aparna Arjunan, Marguerite Byrnes, Margaret Cahill, Alison Craswell, Joel Dulhunty, Amanda Fox, Nicole C. Gavin, Peter Lawrenson, Karen Lee‐Steere, Hui‐Shan Lin, Andrew Teodorczuk, Elise Treleaven, Laura White, Chloe Yap   +15 more
wiley   +1 more source

THE CLINICAL CASE OF PRIMARY PROGRESSIVE APHASIA

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2019
The article described the rare clinical case of the patient with probable transmissible encephalopathy (Creutzfeldt–Jakob disease) in whom rapidly forming primary progressive aphasia was the herald clinical feature, and motor and sensory functions were ...
Natalya V. Shuleshova, Aleksey V. Sizov, Irina V. Kupriianova, Victoria V. Zvereva   +3 more
doaj   +1 more source

Eating behaviour profiles across the frontotemporal dementia spectrum

Journal of Neuropsychology, EarlyView.
Abstract Altered eating behaviours are a hallmark of behavioural variant frontotemporal dementia (bvFTD) but are less well characterised in progressive nonfluent aphasia (PNFA) and semantic dementia (SD). We investigated the frequency and onset of eating behaviour changes across the three subtypes.
Yuki Sato, Hitomi Hayashi, Kazuo Kakinuma, Chifumi Iseki, Shoko Ota, Kazuto Katsuse, Shiho Matsubara, Nobuko Kawakami, Shigenori Kanno, Keisuke Morihara, Yoshiyuki Nishio, Kyoko Suzuki   +11 more
wiley   +1 more source

An interdisciplinary approach aiding the diagnosis of primary progressive aphasia: A case report

Dementia & Neuropsychologia
Frontotemporal dementia (FTD) is one of the most common causes of early-onset dementia with primary progressive aphasia (PPA) being the second-most-frequent form of this degenerative disease.
Nadia Shigaeff, Mayra Zanetti, Sibelle de Almeida Tierno, Ana Beatriz Galhardi Di Tommaso, Thais Cristina Marques, Fábio Gazelato de Mello Franco   +5 more
doaj   +1 more source

The Effect of Alexithymia, Metacognitive Beliefs and Self‐Efficacy on Disability in Patients With Schizophrenia: A Cross‐Sectional Study

Journal of Psychiatric and Mental Health Nursing, Volume 33, Issue 3, Page 516-527, June 2026.
ABSTRACT Introduction Schizophrenia is a chronic mental disorder and one of the leading causes of disability worldwide, with greater levels of disability being associated with lower general self‐efficacy. Reducing disability and enhancing self‐sufficiency in individuals diagnosed with schizophrenia are among the primary goals of treatment and care ...
Hatice Polat, Kerim Uğur, Tunahan Sun
wiley   +1 more source

Digital seed amplification assay for TDP‐43 aggregate quantification in CSF

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg, Zoe Swank, Tal Gilboa, Lily A. Wickland Shearer, Arek V. Melkonian, Justin C. Rolando, David R. Walt, Andrew M. Stern   +7 more
wiley   +1 more source