Results 61 to 70 of about 16,364 (195)

Associations between TMEM106B C‐terminal fragment aggregation, age, and TDP‐43 or tau pathology

Brain Pathology, EarlyView.
TMEM106B C‐terminal fragment (CTF) aggregation represents an age‐associated, common, diffuse phenomenon emerging after midlife with a weak association with TDP‐43 or tau pathology. These findings suggest that TMEM106B fibrillization may define a distinct axis of protein aggregation in the aging human brain. Abstract Transmembrane protein 106B (TMEM106B)
Albert Acewicz, Sylwia Tarka, Michał Grzegorczyk, Radosław Rzepliński, Teresa Wierzba‐Bobrowicz, Tomasz Stępień   +5 more
wiley   +1 more source

Care Needs for Patients Screened Positive for Cognitive Impairment and Delirium: A Cross‐Sectional Observational Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To describe the point prevalence of cognitive impairment in hospitalised adults and evaluate the association with care needs and perceived risks of complications. Design Multi‐site cross‐sectional study on a single day in May 2023. Methods Trained clinician auditors screened adult inpatients in acute medical, surgical, oncology, geriatric,
Alison M. Mudge, Sarah Anderson, Aparna Arjunan, Marguerite Byrnes, Margaret Cahill, Alison Craswell, Joel Dulhunty, Amanda Fox, Nicole C. Gavin, Peter Lawrenson, Karen Lee‐Steere, Hui‐Shan Lin, Andrew Teodorczuk, Elise Treleaven, Laura White, Chloe Yap   +15 more
wiley   +1 more source

An Ecological and Processual Understanding of Family Resilience in Dementia: A Qualitative Meta‐Synthesis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how family resilience emerges and unfolds in dementia. Design Qualitative meta‐synthesis using thematic synthesis. Data Sources PubMed, CINAHL, Web of Science, PsycINFO were searched from inception through August 26, 2025. Methods Studies examining family‐level resilience, adaptation or coping in home‐based dementia care using ...
Yoosun Yang, Jun‐Ah Song
wiley   +1 more source

Cognitive decline in Dutch‐type hereditary and sporadic cerebral amyloid angiopathy: a 5‐year follow‐up study

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but its longitudinal course of cognitive decline remains unclear. We investigated domain‐specific cognitive trajectories in Dutch‐type hereditary (D‐CAA) and sporadic CAA (sCAA) to compare patterns and rates of decline. METHODS We included 181 participants –
Rosemarie van Dort, Vera C. J. van Stek‐Smits, Sanne E. Schriemer, Reinier G. J. van der Zwet, Manon R. Schipper, Sabine Voigt, Ellen P. Hart, Vandhana Easwaran, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Matthias J. P. van Osch, Marianne A. A van Walderveen, Marieke J. H. Wermer, Ellis S. van Etten   +16 more
wiley   +1 more source

Atypical Case of Takayasu Aortitis Presenting as Embolic Stroke With Concomitant Massive Thoracic Artery Aneurysm

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Multifocal aortic aneurysmal dilatation as evidenced by CT Angiography chest‐abdomen‐pelvis of the ascending aorta (A), aortic arch (B), and suprarenal abdominal aorta (C), measuring 6.0 × 6.0, 4.5 × 4.5, and 4.1 × 3.7 cm, respectively. ABSTRACT We describe the case of a 44‐year‐old female with a history significant for only hypertension who presented ...
J. Curran Henson, Jordan H. Myers, Macy Cummins, Keyur Vyas, Michael Lowry   +4 more
wiley   +1 more source

Communication Partner Training Practices for People With Aphasia Among Latin American Speech and Language Therapists: A Survey of Implementation Barriers and Facilitators

International Journal of Language &Communication Disorders, Volume 61, Issue 4, July/August 2026.
ABSTRACT Background Communication Partner Training (CPT) is an evidence‐based approach that enhances conversation and participation for people with aphasia (PwA) by involving their communication partners (CPs) in therapy. Although CPT is endorsed in international guidelines, little is known about its application in Latin American contexts, where ...
Claudia Olivares‐Matus, Anna Volkmer, Suzanne Beeke   +2 more
wiley   +1 more source

Rate and rhythm control strategies for apraxia of speech in nonfluent primary progressive aphasia

Dementia & Neuropsychologia
The nonfluent/agrammatic variant of primary progressive aphasia is characterized by apraxia of speech and agrammatism. Apraxia of speech limits patients' communication due to slow speaking rate, sound substitutions, articulatory groping, false starts and
Bárbara Costa Beber, Monalise Costa Batista Berbert, Ruth Siqueira Grawer, Maria Cristina de Almeida Freitas Cardoso   +3 more
doaj   +1 more source

A Case of Functional Movement Disorder Preceding Right Temporal Predominant Frontotemporal Degeneration

Movement Disorders Clinical Practice, EarlyView.
Isis So, Aditya Murgai, Elizabeth C. Finger, Miguel Restrepo‐Martinez   +3 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, Volume 36, Issue 4, July 2026.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

A decade with anomic primary progressive aphasia

eNeurologicalSci
Some patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations of anomic PPA precluded us from determining whether progressive anomic aphasia was simply an early stage of semantic or logopenic variants,
Shoko Ota, Kazuo Kakinuma, Wataru Narita, Yoshiyuki Nishio, Nobuko Kawakami, Ayane Tamagake, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki   +8 more
doaj   +1 more source