Results 31 to 40 of about 11,793 (163)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Evaluation of the clinical characteristics of patients with PFAPA syndrome according to attack triggers

Trends in Pediatrics
Objective: Based on our clinical observations, this study aimed to evaluate the spectrum of triggers for febrile attacks in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) and to investigate whether clinical
Lütfiye Koru, Elif Selcen Yabancı Erten, Feray Kaya, Elif Küçük, Zelal Aydın, Eda Nur Dizman, Hatice Kübra Dursun, Merve Özen Balcı, Ufuk Furkan Özdemir, Kübra Öztürk, Fatih Haşlak   +10 more
doaj   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source

Chronic ulcerative oesophagitis rich in IgG4‐positive plasma cells – a distinct clinicopathological entity

Histopathology, EarlyView.
We report a series of 12 patients (mean age 63 years) with chronic oesophageal ulceration showing morphological features of IgG4‐related inflammatory disease. Most patients underwent several rounds of endoscopy until this association was recognized. The majority of patients went into clinical and histological remission following corticosteroid therapy.
Hanna Henzinger, Ian Brown, Anthony J Gill, Tomas Slavik, Giuseppe Zamboni, Cord Langner   +5 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Mucoadhesive Drug Delivery Systems for Oral Chronic Inflammatory Mucosal Diseases. The Future is Already Present. A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Background Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are considered the most painful oral inflammatory diseases, with high global prevalence and significant impacts on patients' quality of life. In the last decades, researchers have been exploring mucoadhesive drug delivery systems (MDDS) to improve drugs safety and ...
M. E. Mauceri, M. Coppini, V. De Caro, G. Di Prima, R. Mauceri, V. Panzarella, G. Giuliana, G. Campisi   +7 more
wiley   +1 more source

OralSegNet: An Approach to Early Detection of Oral Disease Using Transfer Learning

Oral Diseases, EarlyView.
ABSTRACT Objective Deep learning‐based segmentation system is proposed that exploits three variants of YOLOv11 architecture, namely YOLOv11n‐seg, YOLOv11s‐seg, and YOLOv11m‐seg for automated detection and localization of the oral disease conditions from photographic intraoral images.
Pranta Barua, Md Rakibul Islam, Mahmud Uz Zaman, Adel Alenazi, Fawaz Alqahtani, Huda Abutayyem, Maher Al Shayeb, Ruba Odeh, Nesrine A. Elsahn, Mohammad Khursheed Alam   +9 more
wiley   +1 more source

Vitamin D levels in patients with recurrent aphthous stomatitis

BMC Oral Health, 2018
Background Lower serum vitamin D levels, a major public health problem worldwide, has been found to be associated with various infectious diseases, cancers, autoimmune and dermatological diseases.
Aynure Öztekin, Coşkun Öztekin
doaj   +1 more source

Dermatologic Findings of RELA‐Associated Autoinflammatory Disease

Pediatric Dermatology, EarlyView.
ABSTRACT Variants in the gene RELA have been implicated in a monogenic, hereditary form of Behcet's‐like syndrome. This case series describes the dermatologic manifestations of three patients with identified RELA‐associated autoinflammatory disease.
Elizabeth Nourse, Vidya Sivaraman, Catherine G. Chung, Shoghik Akoghlanian, Esteban Fernandez Faith   +4 more
wiley   +1 more source