Results 121 to 130 of about 201,051 (250)

Generation of apical-out nasal organoids to facilitate viral infection and drug screening

Abstract Advanced culture systems such as organoids can serve as powerful platforms to study epithelial physiology, as they recapitulate the organisation and many key functions of the tissue of origin. The nasal epithelium is the first respiratory epithelium that is exposed to inhaled airborne pathogens.
Georgios Stroulios, Mathieu Hubert, Wing Chang, Allen Eaves, Sharon Louis, Philipp Kramer, Caroline Tapparel, Salvatore Simmini   +7 more
openaire   +1 more source

Triblock Polymer Engineering Enables Hydration‐Rich, High‐Performance, Fouling‐Resistant Interfaces

Advanced Functional Materials, EarlyView.
A molecularly engineered triblock polymer (PHZ) rapidly reorganizes into a hydration‐rich interfacial layer on diverse surfaces, strongly suppressing hydrophobic attraction and fouling. The triblock polymer provides robust energy and steric barriers to oily foulants, enabling high‐performance antifouling at ultralow dosage.
Chenyu Qiao, Ziqian Zhao, Yueying Huang, Yongxiang Sun, Genglin Li, Xuguang Song, Hongbo Zeng   +6 more
wiley   +1 more source

Structured multicellular intestinal spheroids (SMIS) as a standardized model for infection biology [PDF]

Background 3D cell culture models have recently garnered increasing attention for replicating organ microarchitecture and eliciting in vivo-like responses, holding significant promise across various biological disciplines.
Alter, Thomas, Einspanier, Ralf, Gölz, Greta, Hanisch, Carlos, Heimesaat, Markus M., Klopfleisch, Robert, Kraski, Angelina, Migdał, Paweł, Räckel, Clara, Sharbati, Jutta, Sharbati, Soroush   +10 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Comparative analysis of immune responses of intestinal organoids from wild rodents upon infection: Challenging the Toxoplasma gondii / house mouse model [PDF]

Die Epithelzellen des Dünndarms bilden die Hauptinfektionsroute für viele Protozoen wie zum Beispiel Toxoplasma gondii und Giardia duodenalis. Jedoch sind die Mechanismen dieser Infektionswege unbekannt, da geeignete Modelle fehlen, welche das ...
Delgado Betancourt, Estefania
core   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Clinical, experimental and pathophysiological effects of Yaq-001: a non-absorbable, gut-restricted adsorbent in models and patients with cirrhosis [PDF]

Objective: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in ...
Albillos, Agustín, Andreola, Fausto, Arroyo, Vicente, Avery, Thomas, Caraceni, Paolo, Church, Karen, Clasen, Frederick, Cordero, Paul, Cortez-Pinto, Helena, Cox, I Jane, Davies, Nathan, De Chiara, Francesco, Durand, Francois, Eaton, Simon, Edwards, Lindsey A, Elosua, Roberto, Gander, Amir, Gines, Pere, Green, Daniel, Habtesion, Abeba, Husi, Katherine, Ingavle, Ganesh, Jalan, Aarti, Jalan, Rajiv, Ji, Huoyan, Jimenez, Cesar, Jin, Qin, Jin, Yi, Kerbert, Annarein JC, Kowalski, Michal, Li, Jia V, Liu, Jinxia, MacNaughtan, Jane, Marchesi, Julian, Martínez Gonzalez, Javier, McConaghy, Lynda, Mehta, Gautam, Mookerjee, Rajeshwar P, Morgan, Carrie, Oben, Jude, Pavesi, Marco, Phillips, Alexandra, Portlock, Theo, Rodriguez Gandia, Miguel Angel, Sandeman, Susan, Shoaie, Saeed, Soeda, Junpei, Solà, Elsa, Vargas, Victor, Vila, Joan, Wiest, Reiner, Wu, Haifeng, Zaccherini, Giacomo   +52 more
core  

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

The Role of Viruses in Pulpal and Apical Disease: A Systematic Review

Viruses
Apical lesions are diseases of infectious origin that can cause destruction of the surrounding periapical tissue, including bone tissue and periodontal ligaments, resulting in the loss of the affected teeth.
Katia Hermosilla Hermosilla, Paula Soto Cárdenas, Manuel Donoso Zuñiga, Cecilia Pérez Ñanco, Scarlette Hernández-Vigueras   +4 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source