Results 1 to 10 of about 106,655 (301)

Organoid Models and Next-Generation Sequencing for Bone Marrow and Related Disorders

Organoids, 2023
Challenges to the musculoskeletal system negatively impact the quality of life of people suffering from them, leading to pain, a decline in mobility, genetic alterations, and potential disorders.
Magdalena Rausch, Neelam Iqbal, Shelly Pathak, Heather E. Owston, Payal Ganguly   +4 more
doaj   +1 more source

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Molecular Medicine, 2022
Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo   +13 more
doaj   +1 more source

Contraindicated Drug Responses in Dravet Syndrome Brain Organoids Utilizing Micro Electrode Array Assessment Methods

Organoids, 2023
Ensuring drug safety for patients with specific neurological disorders is of paramount importance. For instance, certain antiepileptic drugs (AEDs) are contraindicated in Dravet Syndrome (DS), which is characterized by a deficiency in Na+ channel ...
Remi Yokoi, Nami Nagafuku, Yuto Ishibashi, Naoki Matsuda, Ikuro Suzuki   +4 more
doaj   +1 more source

The Rapid Generation of Cell-Laden, FACS-Compatible Collagen Gels

Organoids, 2023
A three-dimensional cell culture in hydrogel beads can support cell growth and differentiation into multi-cellular structures, and these gel beads could be used as building blocks for more complex three-dimensional assemblies.
Yi Xiao, Qiaoling Huang, Jesse W. Collins, Julie Brouchon, Jeffery A. Nelson, Zachary Niziolek, Alison O’Neil, Fangfu Ye, David A. Weitz, John A. Heyman   +9 more
doaj   +1 more source

A Microwell Device for the Efficient Generation of Arrays of Microtissues and Humanized Bone Marrow Micro-Ossicles

Organoids, 2023
(1) Background: There are no high-throughput microtissue platforms for generating bone marrow micro-ossicles. Herein, we describe a method for the assembly of arrays of microtissues from bone marrow stromal cells (BMSC) in vitro and their maturation into
Kathryn Futrega, Md. Shafiullah Shajib, Pamela G. Robey, Michael R. Doran   +3 more
doaj   +1 more source

Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease

Organoids, 2023
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for infection and ...
Pin Shie Quah, Bang M. Tran, Vincent D.A. Corbin, Jessie J.-Y. Chang, Chinn Yi Wong, Andrés Diaz-Méndez, Carol A. Hartley, Weiguang Zeng, Eric Hanssen, Zlatan Trifunovic, Patrick C. Reading, David C. Jackson, Elizabeth Vincan, Lachlan J.M. Coin, Georgia Deliyannis   +14 more
doaj   +1 more source

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent [PDF]

, 2020
Induced pluripotent stem cell (iPSC)‐derived retinal organoids provide a platform to study human retinogenesis, disease modeling, and compound screening.
Armstrong, Lyle, Carter, Madeleine, Chichagova, Valeria, Georgiou, Maria, Ghareeb, Ali, Hilgen, Gerrit, Lako, Majlinda, Sernagor, Evelyne   +7 more
core   +2 more sources

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa, Compte, Marta, Cuesta, Ángel M., Fernández-Periáñez, Rodrigo, Guijarro-Muñoz, Irene, Molina-Privado, Irene, Rojo, Federico, Sanz, Laura, Sánchez-Martín, David, Zazo, Sandra, Álvarez-Cienfuegos, Ana, Álvarez-Méndez, Ana M., Álvarez-Vallina, Luis   +12 more
core   +4 more sources

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]

, 2016
EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Bounova, Gergana, Cornelissen-Steijger, Paulien, de Vries, Nienke, Koppens, Martijn A.J., Sansom, Owen J., van Lohuizen, Maarten, Wessels, Lodewyk F.A.   +6 more
core   +1 more source

The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis [PDF]

, 2017
PTPRB is a transmembrane protein tyrosine phosphatase known to regulate blood vessel remodelling and angiogenesis. Here we demonstrate that PTPRB negatively regulates branching morphogenesis in the mammary epithelium.
Gusterson, Barry A., Isacke, Clare M., Kendrick, Howard, Meniel, Valerie, Morris, Joanna S., Olijnyk-Dallis, Daria, Smalley, Matthew J., Soady, Kelly J., Stein, Torsten, Tornillo, Giusy   +9 more
core   +3 more sources