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The Next Generation of Organoids Will Be More Complex and Even Closer to Resembling Real Organs: An Interview with Prof. Dr. Hans Clevers

Organoids
In this issue, we are pleased and honored to have an interview with Professor Hans Clevers, who is the Advisory Board Member of Organoids [...]
Süleyman Ergün, Organoids Editorial Office   +1 more
doaj   +2 more sources

Suspension-cultured taste bud organoids recapitulate in vivo taste buds [PDF]

, 2023
Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this
정한성, 이종민
core   +1 more source

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Molecular Medicine, 2022
Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo   +13 more
doaj   +1 more source

Applications for Colon Organoid Models in Cancer Research

Organoids, 2023
Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or disease from which they are derived. Due to their stem cell origin, organoids contain a heterogeneous population of cells reflecting the diversity of cell types
Matthew J. Munro, Swee T. Tan, Clint Gray   +2 more
doaj   +1 more source

Organoids as Miniature Twins—Challenges for Comparability and Need for Data Standardization and Access

, 2022
Organoids derived from human stem cell lines represent genetically mostly identical models of their donors. Their use as personalized in vitro miniature twins of living individuals creates challenges of reproducibility, comparability and standardization.
Sabine Müller, Christian Hiepen, Antonie Fuhr, Hiepen, Christian, Kurtz, Andreas, Müller, Sabine, Andreas Kurtz, Fuhr, Antonie   +7 more
core   +1 more source

Modeling HEV infection in human liver organoids

, 2021
Fetal and adult human liver organoids were used to replicate hepatitis E virus (HEV).
Pan, PhD Q. (Erasmus MC)
core   +1 more source

Organoids [PDF]

, 2022
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue.
Zhao, Zixuan, Chen, Xinyi, Fong, E., Chen, Z., Sljukic, Aleksandra, Yu, Hanry, Soragni, Alice, Chen, X., Huch, M., Dowbaj, A., Sljukic, A., Dowbaj, Anna M., Zeng, Y., Lin, Luda, Balachander, Gowri Manohari, Wang, Q., Soragni, A., Bratlie, Kaitlin, Chen, Zhaowei, Zeng, Yi Arial, Dowbaj, Anna M, Huch, Meritxell, Zhao, Z., Balachander, G., Bratlie, K., Lin, L., Fong, Eliza Li Shan, Yu, H., Wang, Qun   +28 more
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Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics. [PDF]

Adv Sci (Weinh)
Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Pantula A, Joshi K, Samant S, Babakhanova G, Kathuria A.   +4 more
europepmc   +2 more sources

Strategies for vascularization in kidney organoids [PDF]

, 2022
The establishment of protocols for differentiating kidney organoids from human pluripotent stem cells (hPSCs) has potential for the application of kidney organoids in regenerative medicine. However, the primary obstacle to the regenerative application of
Yong Kyun Kim, Seo-Yeon Park
core   +1 more source

From organoids to gastruloids [PDF]

, 2017
Last year was hailed as ‘the year of the organoid’ as news of mini- brains, livers and intestines grown in the laboratory hit the headlines. Here, Dr David Turner explains the latest in vitro systems for modelling human development and disease, including
Turner, DA
core   +2 more sources