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Organoids [PDF]

Nature Reviews Methods Primers, 2022
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue.
Zhao, Zixuan, Chen, Xinyi, Fong, E., Chen, Z., Sljukic, Aleksandra, Yu, Hanry, Soragni, Alice, Chen, X., Huch, M., Dowbaj, A., Sljukic, A., Dowbaj, Anna M., Zeng, Y., Lin, Luda, Balachander, Gowri Manohari, Wang, Q., Soragni, A., Bratlie, Kaitlin, Chen, Zhaowei, Zeng, Yi Arial, Dowbaj, Anna M, Huch, Meritxell, Zhao, Z., Balachander, G., Bratlie, K., Lin, L., Fong, Eliza Li Shan, Yu, H., Wang, Qun   +28 more
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Engineered organoids for biomedical applications

Advanced Drug Delivery Reviews, 2023
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications.
Ali Khademhosseini
exaly   +2 more sources

Organoids: a systematic review of ethical issues [PDF]

Stem Cell Research and Therapy, 2022
Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen
Muller J., Mey D., Pal-Kutas K., Bellofatto K., Lei Y., Buerck L. W. -V., Berishvili E., Kugelmeier P., Campo F., Thaunat O., Massey E. K., Wolint P., Olgasi C., Muhlemann M., Pellegrini S., Lebreton F., Bignard J., Pehl M., Piemonti L., Cavallaro M., Borsotti C., de Jongh D., Cronin A. J., Gotz J., Honarpisheh M., Citro A., Cucci A., Rossi G., Assanelli S., Pignatelli C., Seissler J., Parisotto C., Bunnik E. M., Fonseca L. M., Zhang Y., Follenzi A.   +35 more
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Suspension-cultured taste bud organoids recapitulate in vivo taste buds [PDF]

, 2023
Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this
정한성, 이종민
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Organoids as Miniature Twins—Challenges for Comparability and Need for Data Standardization and Access

, 2022
Organoids derived from human stem cell lines represent genetically mostly identical models of their donors. Their use as personalized in vitro miniature twins of living individuals creates challenges of reproducibility, comparability and standardization.
Sabine Müller, Christian Hiepen, Antonie Fuhr, Hiepen, Christian, Kurtz, Andreas, Müller, Sabine, Andreas Kurtz, Fuhr, Antonie   +7 more
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Modeling HEV infection in human liver organoids

, 2021
Fetal and adult human liver organoids were used to replicate hepatitis E virus (HEV).
Pan, PhD Q. (Erasmus MC)
core   +1 more source

Generating human striatal organoids.

, 2022
(A) The schematic of brain organoid protocol with a ventral drug-patterning application (purmorphamine) during culture. (B) The morphology of organoids with different concentrations of ventral drug-patterning applications in culture.
Yuqi Wang (270190), Lixiang Ma (4006619), Xuan Li (137217), Rong Ji (1496803), Yang Liu (4829), Hexige Saiyin (141992), Xinyu Chen (47670)   +6 more
core   +1 more source

Beating Heart Organoids

, 2022
Supplemental Video LegendsVideo 1: Beating RA- heart organoids at day 30 from WTC line with an ACTN2-eGFP reporter.Video 2: Beating RA+ heart organoids at day 30 from WTC line with an ACTN2-eGFP reporter.Video 3: Beating RA- heart organoids at day 15 ...
WEI FENG (12246134), Dennis Kostka (12250535), Guang Li (12246131), Hannah Schriever (12246077)   +3 more
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Equine Oviductal Organoid Generation and Cryopreservation

, 2022
Organoids are a type of three-dimensional (3D) cell culture that more closely mimic the in vivo environment and can be maintained in the long term. To date, oviductal organoids have only been reported in laboratory mice, women, and cattle.
Thompson, Riley E., Veeramachaneni, D. N. Rao, Pukazhenthi, Budhan S., Hollinshead, Fiona K., Fiona K. Hollinshead, Mindy A. Meyers, Riley E. Thompson, Budhan S. Pukazhenthi, Meyers, Mindy A., D. N. Rao Veeramachaneni   +9 more
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Stem cells for organoids

, 2022
Organoids are three‐dimensional (3D) cell culture systems that simulate the structures and functions of organs, involving applications in disease modeling, drug screening, and cellular developmental biology. The material matrix in organoids can provide a
Shutong Qian, Wenguo Cui, Binfan Zhao, Zhimo Liu, Jiayi Mao, Xiaoming Sun, Qiuyu Zhao, Liucheng Zhang, Bolun Lu, Xiyuan Mao, Liying Cheng, Yuguang Zhang   +11 more
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