Disease modeling and drug screening using human airway organoids: a systematic review [PDF]
Organoid, 2021 Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
doaj +2 more sources
Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments [PDF]
Organoid, 2022 Background Animal experiments have been performed to predict toxicity in humans in many fields, in-cluding toxicology, medicine, and pharmacology, and have contributed to increasing life ex-pectancy. However, animal testing has been a controversial issue
Jooyeon Lee +7 more
doaj +2 more sources
Technical advances in pluripotent stem cell-derived and tumorigenic organoids [PDF]
Organoid, 2022 Cell culture systems have been widely used to address fundamental questions in biology without sacrificing animals. Three-dimensional (3D) organoids provide more information on in vivo conditions than traditional culture systems because multiple cell ...
Suwon Kang +3 more
doaj +2 more sources
Rapid anticancer drug screening using patient-derived lung cancer organoids: a case report [PDF]
Organoid, 2022 A variety of anticancer drugs and targeted agents for lung cancer have been developed, but some patients do not respond to these medications as intended.
Hyeong Jun Cho +6 more
doaj +2 more sources
The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases [PDF]
Organoid, 2022 The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be stably cultured over ...
Panida Sittipo, Yun Kyung Lee
doaj +2 more sources
A method for culturing patient-derived lung cancer organoids from surgically resected tissues and biopsy samples [PDF]
Organoid, 2022 Background The cancer model system maintaining genetic and phenotypic characteristics of human cancers is crucial for the study of precision cancer medicine.
Yu Ri Ko +4 more
doaj +2 more sources
Lung organoids: target cells for understanding respiratory diseases [PDF]
Organoid, 2021 Human respiratory disease research currently lacks in vitro models that recapitulate most of the physiology and architecture of the lung. Furthermore, the complex composition and structure of the lung, as well as anatomical differences between humans and
Jooyeon Lee, Se-Ran Yang
doaj +2 more sources
Emerging organoid-based platforms to study salivary gland hypofunction [PDF]
Organoid, 2022 Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease.
Yoojin Seo, Hyung-Sik Kim
doaj +2 more sources
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj +2 more sources
Recent advances and challenges in organoid-on-a-chip technology [PDF]
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
core +1 more source