Results 31 to 40 of about 67,145 (248)
Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics. [PDF]
Adv Sci (Weinh)Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Pantula A +4 more
europepmc +2 more sources
Single-cell transcriptomics of lung organoids [PDF]
, 2021 The in vitro application of human pluripotent stem cell- or adult stem cell-derived lung organoids has the potential to revolutionize lung disease research, but there are several limitations in the consistent implementation of lung organoids resulting ...
Ye Na Song, Man Ryul Lee
core +1 more source
ChatGPT: The cognitive effects on learning and memory
Brain-X, 2023 As the integration of artificial intelligence (AI) into our daily lives and educational environments becomes increasingly prevalent, it is necessary to understand the way in which these technologies impact cognitive functions.
Long Bai, Xiangfei Liu, Jiacan Su
doaj +1 more source
Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
doaj +1 more source
Stress granule formation as a marker of cellular toxicity in lung organoids [PDF]
, 2022 Cells regulate protein synthesis under stressful circumstances by forming cytoplasmic RNA granules, termed stress granules (SGs). SGs are membrane-less organelles that function as a protective mechanism in response to stress. They function through liquid-
Seung-Yeon Kim, Kee K. Kim, Eun-Mi Kim
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Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]
Organoid, 2023 Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song +4 more
doaj +1 more source
Gastric stem cell research and gastric organoids [PDF]
, 2022 The stomach is a complex organ lined with ordered epithelium consisting of different adult stem cell (ASC) pools. In the previous decade, research into gastric epithelial stem cells has been performed using lineage tracing methods, and several putative ...
Haengdueng Jeong, Ki Taek Nam
core +1 more source
BMC Urology, 2023 Background In intermediate-risk non-muscle invasive bladder cancer (NMIBC) clinical guidelines suggest an adjuvant instillation with a chemotherapeutic agent. However, the agent and regimen are not clearly defined.
Roland Seiler +10 more
doaj +1 more source
Natural biopolymer-based hydrogels as designer matrices for organoid cultures [PDF]
Organoid, 2023 Matrigel, a mouse sarcoma-derived extract, is considered the gold standard for organoid cultures. However, it has several drawbacks, including inconsistent and ill-defined composition, varying quality between batches, and potential cancer-related health ...
Yun Kee Jo
doaj +1 more source
Endoplasmic reticulum stress and organoids [PDF]
, 2021 Organoids represent an advanced tool in cell biology and have redefined biomedical research. Organoids are ideal for studies of biological processes, pharmacological studies, and therapeutic research to imitate pathological processes and preserve genetic
Mohammad Fazlul Kabir +3 more
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