Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids [PDF]
, 2021 Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not
Dong-Hun Woo +3 more
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Glioblastoma organoid technology: an emerging preclinical models for drug discovery [PDF]
, 2022 Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis.
Shuchang Zhou +3 more
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Progress, prospects, and limitations of organoid technology [PDF]
, 2022 Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs.
Jung Kyu Choi +2 more
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Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Dong-Hun Woo +7 more
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Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Byoung-San Moon +3 more
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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Toward brain organoid-based precision medicine in neurodegenerative diseases [PDF]
, 2022 In recent years, the concept of precision medicine—an approach to developing personalized drugs for disease prevention or treatment—has emerged as an up-and-coming field in medical research.
Inhee Mook-Jung, Jong-Chan Park
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Therapeutic applications of three-dimensional organoid models in lung cancer [PDF]
, 2021 Lung cancer, which remains a major cause of mortality worldwide, is a histologically diverse condition and demonstrates substantial phenotypic and genomic diversity among individual patients, manifesting as both intertumoral and intratumoral ...
Yongki Hwang +9 more
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Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]
, 2022 Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Jung-Hyun Kim +4 more
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Microengineered organoids: reconstituting organ-level functions in vitro [PDF]
, 2023 In vitro miniaturized organoids are innovative tools with varying applications in biomedical engineering, such as drug testing, disease modeling, organ development studies, and regenerative medicine. However, conventional organoid development has several
Harshita Sharma +6 more
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