Technical advances in pluripotent stem cell-derived and tumorigenic organoids [PDF]
Organoid, 2022 Cell culture systems have been widely used to address fundamental questions in biology without sacrificing animals. Three-dimensional (3D) organoids provide more information on in vivo conditions than traditional culture systems because multiple cell ...
Suwon Kang +3 more
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Whole Organ Engineering: Approaches, Challenges, and Future Directions
Applied Sciences, 2020 End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage organ failure is organ transplantation.
Sogu Sohn +4 more
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A method for culturing patient-derived lung cancer organoids from surgically resected tissues and biopsy samples [PDF]
Organoid, 2022 Background The cancer model system maintaining genetic and phenotypic characteristics of human cancers is crucial for the study of precision cancer medicine.
Yu Ri Ko +4 more
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Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments [PDF]
Organoid, 2022 Background Animal experiments have been performed to predict toxicity in humans in many fields, in-cluding toxicology, medicine, and pharmacology, and have contributed to increasing life ex-pectancy. However, animal testing has been a controversial issue
Jooyeon Lee +7 more
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The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases [PDF]
Organoid, 2022 The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be stably cultured over ...
Panida Sittipo, Yun Kyung Lee
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Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
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Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]
, 2016 EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Bounova, Gergana +6 more
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Molecular Autism, 2020 The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic ...
Cristina Cheroni +2 more
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Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]
Organoid, 2023 Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song +4 more
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ChatGPT: The cognitive effects on learning and memory
Brain-X, 2023 As the integration of artificial intelligence (AI) into our daily lives and educational environments becomes increasingly prevalent, it is necessary to understand the way in which these technologies impact cognitive functions.
Long Bai, Xiangfei Liu, Jiacan Su
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