Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
Organoid, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Athira Pratap +3 more
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Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
Organoid, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Hanbyeol Lee +7 more
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
Organoid, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases [PDF]
Organoid, 2022 The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be stably cultured over ...
Panida Sittipo, Yun Kyung Lee
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Lung organoids: target cells for understanding respiratory diseases [PDF]
Organoid, 2021 Human respiratory disease research currently lacks in vitro models that recapitulate most of the physiology and architecture of the lung. Furthermore, the complex composition and structure of the lung, as well as anatomical differences between humans and
Jooyeon Lee, Se-Ran Yang
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Emerging organoid-based platforms to study salivary gland hypofunction [PDF]
Organoid, 2022 Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease.
Yoojin Seo, Hyung-Sik Kim
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Microengineered organoids: reconstituting organ-level functions in vitro [PDF]
Organoid, 2023 In vitro miniaturized organoids are innovative tools with varying applications in biomedical engineering, such as drug testing, disease modeling, organ development studies, and regenerative medicine. However, conventional organoid development has several
Sunho Park +6 more
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Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
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Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Review on the Vascularization of Organoids and Organoids-on-a-Chip [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The use of human cells for the construction of 3D organ models in vitro based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs in vitro, the 3D models have difficulty in forming a complex vascular ...
Xingli Zhao +10 more
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