Emerging biotechnologies for engineering liver organoids [PDF]
Bioactive MaterialsThe engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao +4 more
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Bioengineering Liver Organoids for Diseases Modelling and Transplantation
Bioengineering, 2022 Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications.
Junzhi Li +5 more
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A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq [PDF]
iScienceSummary: Understanding the cellular characteristics and regulatory networks of cells during the growth of human liver organoids is crucial for comprehending liver development and function.
Qinfeng Ma, Xu Zhang, Jianbo Pan
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Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases [PDF]
BiomedicinesLiver organoids take advantage of several important features of pluripotent stem cells that self-assemble in a three-dimensional culture matrix and reproduce many aspects of the complex organization found within their native tissue or organ counterparts.
Dalia A. Obeid +11 more
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Applications and limitations of pluripotent stem cell-derived liver organoids [PDF]
Chinese Medical Journal. Liver disease is one of leading causes of death worldwide. However, current liver models have limited research progress. Therefore, models that accurately reflect the physiological functions of the human liver are urgently needed in both clinical and ...
Zhiwei Feng +5 more
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Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling [PDF]
Stem Cell Research & TherapyThe lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications.
Weidong Shao +5 more
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Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids [PDF]
Cancer MedicineBackground Liver injury associated with oxaliplatin (L‐OHP)‐based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery.
Kumiko Tatsumi +12 more
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Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate [PDF]
Scientific ReportsLiver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulate in vivo pathology.
Jiyoung Heo +16 more
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Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation [PDF]
BMC BiologyBackground Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation.
Shaoyu Zhong +7 more
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Generation of in vivo-like multicellular liver organoids by mimicking developmental processes: A review [PDF]
Regenerative TherapyLiver is involved in metabolic reactions, ammonia detoxification, and immunity. Multicellular liver tissue cultures are more desirable for drug screening, disease modeling, and researching transplantation therapy, than hepatocytes monocultures ...
Ayumu Okumura +2 more
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