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Emerging biotechnologies for engineering liver organoids [PDF]

Bioactive Materials
The engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao   +4 more
doaj   +4 more sources

High-throughput bioengineering of homogenous and functional human-induced pluripotent stem cells-derived liver organoids via micropatterning technique

Frontiers in Bioengineering and Biotechnology, 2022
Human pluripotent stem cell-derived liver organoids are emerging as more human-relevant in vitro models for studying liver diseases and hepatotoxicity than traditional hepatocyte cultures and animal models.
Xiaodong Xu, Xiaodong Xu, Shanqing Jiang, Longjun Gu, Bin Li, Fang Xu, Changyong Li, Pu Chen, Pu Chen, Pu Chen   +9 more
doaj   +3 more sources

A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq [PDF]

iScience
Summary: Understanding the cellular characteristics and regulatory networks of cells during the growth of human liver organoids is crucial for comprehending liver development and function.
Qinfeng Ma, Xu Zhang, Jianbo Pan
doaj   +2 more sources

Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

Biomolecules, 2021
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and ...
Xv Zhang, Liling Tang, Qian Yi
doaj   +3 more sources

Developing Biliary Atresia-like Model by Treating Human Liver Organoids with Polyinosinic:Polycytidylic Acid (Poly (I:C))

Current Issues in Molecular Biology, 2022
Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C).
Patrick Ho-Yu Chung, Rosana Ottakandathil Babu, Zhongluan Wu, Kenneth Kak-Yuen Wong, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui   +5 more
doaj   +3 more sources

Applications and limitations of pluripotent stem cell-derived liver organoids [PDF]

Chinese Medical Journal
. Liver disease is one of leading causes of death worldwide. However, current liver models have limited research progress. Therefore, models that accurately reflect the physiological functions of the human liver are urgently needed in both clinical and ...
Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Jianbing Mu, Jun Xie, Xiangxiang Pan   +5 more
doaj   +2 more sources

Primary liver cancer organoids and their application to research and therapy

Journal of the National Cancer Center
Primary liver cancer is a leading cause of death worldwide. To create advanced treatments for primary liver cancer, studies have utilized models such as 2D cell culture and in vivo animal models.
Xiaobin Zhu, Rajiv Trehan, Changqing Xie
doaj   +3 more sources

Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling [PDF]

Stem Cell Research & Therapy
The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications.
Weidong Shao, Hui Xu, Kanghua Zeng, Mingzhou Ye, Renjun Pei, Kai Wang   +5 more
doaj   +2 more sources

Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate [PDF]

Scientific Reports
Liver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulate in vivo pathology.
Jiyoung Heo, Dong-Hoon Chae, Hyun Sung Park, Aaron Yu, Jae Han Park, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Dasom Kong, Yoojin Seo, Hyung-Sik Kim, Dongha Bhang, Ki-Sun Park, Mi-Kyung Oh, Kyung-Rok Yu   +16 more
doaj   +2 more sources

Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation [PDF]

BMC Biology
Background Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation.
Shaoyu Zhong, Lu Zheng, Yi Wu, Shujin Sun, Qing Luo, Guanbin Song, Dongyuan Lü, Mian Long   +7 more
doaj   +2 more sources