Results 1 to 10 of about 23,857 (106)

A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq [PDF]

iScience
Summary: Understanding the cellular characteristics and regulatory networks of cells during the growth of human liver organoids is crucial for comprehending liver development and function.
Qinfeng Ma, Xu Zhang, Jianbo Pan
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High-throughput bioengineering of homogenous and functional human-induced pluripotent stem cells-derived liver organoids via micropatterning technique

Frontiers in Bioengineering and Biotechnology, 2022
Human pluripotent stem cell-derived liver organoids are emerging as more human-relevant in vitro models for studying liver diseases and hepatotoxicity than traditional hepatocyte cultures and animal models.
Xiaodong Xu, Xiaodong Xu, Shanqing Jiang, Longjun Gu, Bin Li, Fang Xu, Changyong Li, Pu Chen, Pu Chen, Pu Chen   +9 more
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Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

Biomolecules, 2021
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and ...
Xv Zhang, Liling Tang, Qian Yi
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Emerging biotechnologies for engineering liver organoids [PDF]

Bioactive Materials
The engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao   +4 more
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Developing Biliary Atresia-like Model by Treating Human Liver Organoids with Polyinosinic:Polycytidylic Acid (Poly (I:C))

Current Issues in Molecular Biology, 2022
Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C).
Patrick Ho-Yu Chung, Rosana Ottakandathil Babu, Zhongluan Wu, Kenneth Kak-Yuen Wong, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui   +5 more
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Applications and limitations of pluripotent stem cell-derived liver organoids [PDF]

Chinese Medical Journal
. Liver disease is one of leading causes of death worldwide. However, current liver models have limited research progress. Therefore, models that accurately reflect the physiological functions of the human liver are urgently needed in both clinical and ...
Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Jianbing Mu, Jun Xie, Xiangxiang Pan   +5 more
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Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling [PDF]

Stem Cell Research & Therapy
The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications.
Weidong Shao, Hui Xu, Kanghua Zeng, Mingzhou Ye, Renjun Pei, Kai Wang   +5 more
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Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate [PDF]

Scientific Reports
Liver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulate in vivo pathology.
Jiyoung Heo, Dong-Hoon Chae, Hyun Sung Park, Aaron Yu, Jae Han Park, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Dasom Kong, Yoojin Seo, Hyung-Sik Kim, Dongha Bhang, Ki-Sun Park, Mi-Kyung Oh, Kyung-Rok Yu   +16 more
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Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids [PDF]

Cancer Medicine
Background Liver injury associated with oxaliplatin (L‐OHP)‐based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery.
Kumiko Tatsumi, Hiroshi Wada, Shinichiro Hasegawa, Kei Asukai, Shigenori Nagata, Tomoya Ekawa, Takashi Akazawa, Yu Mizote, Shintaro Okumura, Ryosuke Okamura, Masayuki Ohue, Kazutaka Obama, Hideaki Tahara   +12 more
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Bioengineering Liver Organoids for Diseases Modelling and Transplantation

Bioengineering, 2022
Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications.
Junzhi Li, Jing Chu, Vincent Chi Hang Lui, Shangsi Chen, Yan Chen, Paul Kwong Hang Tam   +5 more
doaj   +3 more sources