Results 31 to 40 of about 26,317 (246)

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]

Organoid, 2022
Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Min Jung Kim, Jaeseo Lee, Seon Ju Mun, Myung Jin Son, Jung-Hyun Kim   +4 more
doaj   +1 more source

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Stem Cell Reports, 2017
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +20 more
doaj   +1 more source

Human liver organoid: modeling liver steatosis and beyond

Cell Regeneration, 2023
AbstractSteatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention. Despite the development of animal models, there is still a lack of the human-relevant platform for steatosis modeling and drug & target discovery.
Jinsong Wei, Wen Zhang, Bing Zhao
openaire   +3 more sources

Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model

Cell Transplantation, 2020
Transplantation of liver organoids has been investigated as a treatment alternative to liver transplantation for chronic liver disease. Transportal approach can be considered as a method of delivering organoids to the liver.
Tomonori Tsuchida, Soichiro Murata, Shunsuke Hasegawa, Satoshi Mikami, Shin Enosawa, Huai-Che Hsu, Akinari Fukuda, Satoshi Okamoto, Akihiro Mori, Megumi Matsuo, Yumi Kawakatsu, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Hideki Taniguchi   +14 more
doaj   +1 more source

Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling

Scientific Reports, 2023
Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems.
Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Jaeseo Lee, Hyun-Soo Cho, Dae-Soo Kim, Kyung-Sook Chung, Myung Jin Son   +7 more
doaj   +1 more source

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +2 more sources

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Advanced Science, 2022
Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is characterized by the dynamic interplay among different organs. The increasing incidence of T2DM reflects an urgent need for the development of in vitro human‐relevant
Tingting Tao, Pengwei Deng, Yaqing Wang, Xu Zhang, Yaqiong Guo, Wenwen Chen, Jianhua Qin   +6 more
doaj   +1 more source

Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids. [PDF]

Hepatobiliary Surg Nutr
Zhang K, Yang H.
europepmc   +3 more sources

Liver organoids: an in vitro 3D model for liver cancer study

Cell & Bioscience, 2022
AbstractPrimary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally in 2015. Due to the lack of an effective model to study HBV-associated liver carcinogenesis,
Renshun Dong, Bixiang Zhang, Xuewu Zhang
openaire   +3 more sources

Advances, challenges and future applications of liver organoids in experimental regenerative medicine. [PDF]

Front Med (Lausanne)
Gong D, Mo J, Zhai M, Zhou F, Wang G, Ma S, Dai X, Deng X.   +7 more
europepmc   +2 more sources