Results 31 to 40 of about 25,342 (266)

Organoid transplant approaches for the liver

Transplant International, 2021
Organoid technology is a state-of-the-art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver.
Hasan Al, Reza, Ryo, Okabe, Takanori, Takebe   +2 more
openaire   +2 more sources

Liver organoids: Current advances and future applications for hepatology. [PDF]

Clin Mol Hepatol
The creation of self-organizing liver organoids represents a significant, although modest, step toward addressing the ongoing organ shortage crisis in allogeneic liver transplantation.
Kim Y, Kang M, Mamo MG, Adisasmita M, Huch M, Choi D.   +5 more
europepmc   +2 more sources

Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell-derived hepatic organoids

iScience, 2023
Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses ...
Jong-Hwan Kim, Seon Ju Mun, Jeong-Hwan Kim, Myung Jin Son, Seon-Young Kim   +4 more
doaj   +1 more source

Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions [PDF]

, 2023
Human induced pluripotent stem cell (iPSC)-derived liver organoids serve as models of organogenesis, disease, drug screening, and regenerative medicine.
Mattis, Aras N, Weng, Yun, Chang, Tammy T, Su, Tao, Sekyi, Maria T, Han, Simon   +5 more
core   +1 more source

Liver Organoids: Recent Developments, Limitations and Potential [PDF]

Frontiers in Medicine, 2021
Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas.
Sean Philip Harrison, Sean Philip Harrison, Saphira Felicitas Baumgarten, Saphira Felicitas Baumgarten, Rajneesh Verma, Rajneesh Verma, Oleg Lunov, Alexandr Dejneka, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan   +11 more
openaire   +5 more sources

Hepatitis C virus infects and perturbs liver stem cells

mBio, 2023
Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk remains unclear.
Nathan L. Meyers, Tal Ashuach, Danielle E. Lyons, Mir M. Khalid, Camille R. Simoneau, Ann L. Erickson, Mehdi Bouhaddou, Thong T. Nguyen, G. Renuka Kumar, Taha Y. Taha, Vaishaali Natarajan, Jody L. Baron, Norma Neff, Fabio Zanini, Tokameh Mahmoudi, Stephen R. Quake, Nevan J. Krogan, Stewart Cooper, Todd C. McDevitt, Nir Yosef, Melanie Ott   +20 more
doaj   +1 more source

Modeling HEV infection in human liver organoids

, 2021
Fetal and adult human liver organoids were used to replicate hepatitis E virus (HEV).
Pan, PhD Q. (Erasmus MC)
core   +1 more source

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

eLife, 2021
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system.
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi   +22 more
doaj   +1 more source

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]

Organoid, 2022
Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Min Jung Kim, Jaeseo Lee, Seon Ju Mun, Myung Jin Son, Jung-Hyun Kim   +4 more
doaj   +1 more source

Human liver organoid: modeling liver steatosis and beyond

Cell Regeneration, 2023
AbstractSteatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention. Despite the development of animal models, there is still a lack of the human-relevant platform for steatosis modeling and drug & target discovery.
Jinsong Wei, Wen Zhang, Bing Zhao
openaire   +3 more sources