Results 31 to 40 of about 24,091 (241)

Hepatitis C virus infects and perturbs liver stem cells

mBio, 2023
Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk remains unclear.
Nathan L. Meyers, Tal Ashuach, Danielle E. Lyons, Mir M. Khalid, Camille R. Simoneau, Ann L. Erickson, Mehdi Bouhaddou, Thong T. Nguyen, G. Renuka Kumar, Taha Y. Taha, Vaishaali Natarajan, Jody L. Baron, Norma Neff, Fabio Zanini, Tokameh Mahmoudi, Stephen R. Quake, Nevan J. Krogan, Stewart Cooper, Todd C. McDevitt, Nir Yosef, Melanie Ott   +20 more
doaj   +1 more source

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

eLife, 2021
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system.
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi   +22 more
doaj   +1 more source

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]

Organoid, 2022
Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Min Jung Kim, Jaeseo Lee, Seon Ju Mun, Myung Jin Son, Jung-Hyun Kim   +4 more
doaj   +1 more source

Advances, challenges and future applications of liver organoids in experimental regenerative medicine [PDF]

Frontiers in Medicine
Xiaoyong Dai, Shaohua Ma, Shaohua Ma
exaly   +2 more sources

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Stem Cell Reports, 2017
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +20 more
doaj   +1 more source

Human liver organoid: modeling liver steatosis and beyond

Cell Regeneration, 2023
AbstractSteatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention. Despite the development of animal models, there is still a lack of the human-relevant platform for steatosis modeling and drug & target discovery.
Jinsong Wei, Wen Zhang, Bing Zhao
openaire   +3 more sources

Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids. [PDF]

Hepatobiliary Surg Nutr
Zhang K, Yang H.
europepmc   +3 more sources

Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model

Cell Transplantation, 2020
Transplantation of liver organoids has been investigated as a treatment alternative to liver transplantation for chronic liver disease. Transportal approach can be considered as a method of delivering organoids to the liver.
Tomonori Tsuchida, Soichiro Murata, Shunsuke Hasegawa, Satoshi Mikami, Shin Enosawa, Huai-Che Hsu, Akinari Fukuda, Satoshi Okamoto, Akihiro Mori, Megumi Matsuo, Yumi Kawakatsu, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Hideki Taniguchi   +14 more
doaj   +1 more source

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]

Front Cell Dev Biol
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH, Jung DJ, Han HJ, Son WC, Jeong GS.   +4 more
europepmc   +4 more sources

Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling

Scientific Reports, 2023
Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems.
Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Jaeseo Lee, Hyun-Soo Cho, Dae-Soo Kim, Kyung-Sook Chung, Myung Jin Son   +7 more
doaj   +1 more source