Results 1 to 10 of about 847,151 (108)

Mechano-modulatory synthetic niches for liver organoid derivation. [PDF]

Nat Commun, 2020
The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling.
Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, Schoonjans K.   +6 more
europepmc   +4 more sources

A Chemically Defined Hydrogel for Human Liver Organoid Culture. [PDF]

Adv Funct Mater, 2020
End-stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for
Ye S, Boeter JWB, Mihajlovic M, van Steenbeek FG, van Wolferen ME, Oosterhoff LA, Marsee A, Caiazzo M, Caiazzo M, van der Laan LJW, Penning LC, Vermonden T, Spee B, Schneeberger K.   +13 more
europepmc   +4 more sources

Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication. [PDF]

Sci Rep, 2022
Lui VC, Hui KP, Babu RO, Yue H, Chung PH, Tam PK, Chan MC, Wong KK.   +7 more
europepmc   +1 more source

Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies. [PDF]

Anal Chem, 2021
Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR.   +13 more
europepmc   +1 more source

Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density. [PDF]

Sci Rep, 2022
Torizal FG, Utami T, Lau QY, Inamura K, Nishikawa M, Sakai Y.   +5 more
europepmc   +1 more source

Integrating CRISPR genome editing with liver organoid and hiPSC-derived microfluidic platforms to model metabolic dysfunction-associated steatotic liver disease. [PDF]

Biochem Biophys Rep
Oluwasegun AK.
europepmc   +1 more source

Construction of liver organoid models by hepatobiliary differentiation from human induced pluripotent stem cells: state of the art, challenges and improving strategies. [PDF]

Stem Cell Res Ther
Wu YH, Wang Y, Zhang WJ, Yuan LL, Chen Y.   +4 more
europepmc   +1 more source

Generation and applications of an expandable and mature hiPSC-derived liver organoid. [PDF]

Acta Pharm Sin B
Liu S, Wang Z, Zhu L, Wang L, Zhao T, Han P, Xu Y, Yang L, Hu L, Yan F, Wang X, Cui T, Li C, Yang B.   +13 more
europepmc   +1 more source

A robust mouse liver organoid platform enables sustained multicellular maturation and fibrosis modeling from a single tissue sample. [PDF]

Sci Rep
Liang Y, Ye Y, Xie H, Lui VCH, Chen Y, Tam PKH.   +5 more
europepmc   +1 more source

Development of NAFLD-Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation. [PDF]

Cell Prolif
You XY, Li XY, Wang H, Zhao GP.
europepmc   +1 more source