Results 31 to 40 of about 19,245 (266)
Cells, 2020 The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation.
Hedwig S. Kruitwagen +22 more
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Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms [PDF]
PeerJ, 2020 Background The use of a personalized liver organoid derived from human-induced pluripotent stem cells (HuiPSCs) is advancing the use of in vitro disease models for the design of specific, effective therapies for individuals. Collecting patient peripheral
Kasem Kulkeaw +3 more
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Recent advances and challenges in organoid-on-a-chip technology
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
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, 2022 Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Jung-Hyun Kim +4 more
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Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease
, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
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Recent advances in multicellular human liver models
, 2022 The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug ...
Youngmi Ji +5 more
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International Journal of Technology, 2020 A liver organoid is an in vitro reconstruction of the liver that mimics the in vivo liver microstructure and performs liver functions. Liver organoids can be used for drug testing, as a model of liver disease pathogenesis, and as a bioartificial ...
Christine Verawaty Sibuea +8 more
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Human Organoids for Predictive Toxicology Research and Drug Development
Frontiers in Genetics, 2021 Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
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Advanced human liver models for the assessment of drug-induced liver injury
, 2022 Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Myung Jin Son +3 more
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Biliary Atresia – emerging diagnostic and therapy opportunities
EBioMedicine, 2021 Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In this review, we describe recent progress in the understanding of liver development with a focus on cholangiocyte differentiation and how use of technical ...
Urban Lendahl +3 more
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