Microengineered organoids: reconstituting organ-level functions in vitro [PDF]
, 2023 In vitro miniaturized organoids are innovative tools with varying applications in biomedical engineering, such as drug testing, disease modeling, organ development studies, and regenerative medicine. However, conventional organoid development has several
Harshita Sharma +6 more
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Human brain organoids in Alzheimer’s disease [PDF]
, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that typically involves neuronal damage leading to the deterioration of cognitive and essential body functions in aging brains.
Hansang Cho, You Jung Kang
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Clinical applications and optimization of patient-derived organoids in intestinal diseases [PDF]
, 2022 Since the first successful establishment of organoids from adult intestinal stem cells, organoid technology has rapidly developed. With advances in normal organoid technology, intestinal disorders, such as colorectal tumors and inflammatory bowel disease,
Tae Il Kim
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Vascular disorders of the liver: recommendations from the Italian Association for the Study of the Liver (AISF) ad hoc committee. [PDF]
, 2011 This review summarizes the document elaborated by the Italian Association for the Study of the Liver (AISF) ad hoc committee "Vascular disorders of the liver" on the primary circulatory liver diseases, which include Budd-Chiari syndrome, obstruction of ...
Riggio O +5 more
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Lung organoids: target cells for understanding respiratory diseases [PDF]
, 2021 Human respiratory disease research currently lacks in vitro models that recapitulate most of the physiology and architecture of the lung. Furthermore, the complex composition and structure of the lung, as well as anatomical differences between humans and
Se-Ran Yang, Jooyeon Lee
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Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection. [PDF]
, 2007 Contains fulltext : 51690.pdf (Publisher’s version ) (Closed access)BACKGROUND: Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass.
Derikx, J.P.M. +15 more
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Gastric stem cell research and gastric organoids [PDF]
, 2022 The stomach is a complex organ lined with ordered epithelium consisting of different adult stem cell (ASC) pools. In the previous decade, research into gastric epithelial stem cells has been performed using lineage tracing methods, and several putative ...
Haengdueng Jeong, Ki Taek Nam
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Disease modeling and drug screening using human airway organoids: a systematic review [PDF]
, 2021 Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Sung Won Kim, Do Hyun Kim
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Emerging organoid-based platforms to study salivary gland hypofunction [PDF]
, 2022 Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease.
Yoojin Seo, Hyung-Sik Kim
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Technical advances in pluripotent stem cell-derived and tumorigenic organoids [PDF]
, 2022 Cell culture systems have been widely used to address fundamental questions in biology without sacrificing animals. Three-dimensional (3D) organoids provide more information on in vivo conditions than traditional culture systems because multiple cell ...
Eun Kyung Bong +3 more
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