Results 31 to 40 of about 18,518 (246)

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

Stem Cell Research, 2014
Pancreatic Lgr5 expression has been associated with organoid-forming epithelial progenitor populations but the identity of the organoid-initiating epithelial cell subpopulation has remained elusive.
Craig Dorrell, Branden Tarlow, Yuhan Wang, Pamela S. Canaday, Annelise Haft, Jonathan Schug, Philip R. Streeter, Milton J. Finegold, Lincoln T. Shenje, Klaus H. Kaestner, Markus Grompe   +10 more
doaj   +1 more source

Liver Organoids as an In Vitro Model to Study Primary Liver Cancer

International Journal of Molecular Sciences, 2023
Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide. Bi-dimensional in vitro models are unable to recapitulate the key features of PLC; consequently, recent advancements in three-dimensional in vitro systems, such as organoids, opened up ...
Silvia De Siervi, Cristian Turato
openaire   +3 more sources

Liver organoids: Current advances and future applications for hepatology [PDF]

Clinical and Molecular Hepatology
The creation of self-organizing liver organoids represents a significant, although modest, step toward addressing the ongoing organ shortage crisis in allogeneic liver transplantation.
Yohan Kim, Minseok Kang, Michael Girma Mamo, Michael Adisasmita, Meritxell Huch, Dongho Choi   +5 more
doaj   +1 more source

Scalable production of tissue-like vascularized liver organoids from human PSCs

Experimental and Molecular Medicine, 2023
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver.
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, María Eugenia de la Morena-Barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Pérez, Henning Kempf, Kathrine S. Åsrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Frøydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan   +35 more
doaj   +1 more source

Droplet-engineered organoids recapitulate parental tissue transcriptome with inter-organoid homogeneity and inter-tumor cell heterogeneity

Fundamental Research
Organoids are expected to function as effective human organ models for precision cancer studies and drug development. Currently, primary tissue-derived organoids, termed non-engineered organoids (NEOs), are produced by manual pipetting or liquid handling
Haoran Zhao, Yifan Cheng, Jiawei Li, Jiaqi Zhou, Haowei Yang, Feng Yu, Feihong Yu, Davit Khutsishvili, Zitian Wang, Shengwei Jiang, Kaixin Tan, Yi Kuang, Xinhui Xing, Shaohua Ma   +13 more
doaj   +1 more source

Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges

Bioengineering
Hepatic cancer is widely regarded as the leading cause of cancer-related mortality worldwide. Despite recent advances in treatment options, the prognosis of liver cancer remains poor.
Abdullah Jabri, Jibran Khan, Bader Taftafa, Mohamed Alsharif, Abdulaziz Mhannayeh, Raja Chinnappan, Alaa Alzhrani, Shadab Kazmi, Mohammad Shabab Mir, Aljohara Waleed Alsaud, Ahmed Yaqinuddin, Abdullah M. Assiri, Khaled AlKattan, Yogesh K. Vashist, Dieter C. Broering, Tanveer Ahmad Mir   +15 more
doaj   +1 more source

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Communications Biology, 2021
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer.
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk   +16 more
doaj   +1 more source

Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease

EXCLI Journal : Experimental and Clinical Sciences, 2023
Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug ...
Negar Aasadollahei, Niloufar Rezaei, Reihaneh Golroo, Tarun Agarwal, Massoud Vosough, Abbas Piryaei   +5 more
doaj   +1 more source

Current advances and prospects in biomaterials-guided tools for liver organoids research

Engineered Regeneration
Liver is the largest solid organ in the human body engaged in an array of critical physiological activities that primarily support metabolism, digestion, nutrient storage, detoxification.
Sana Ahmed, Eman Alshehri, Sarah Nazneen, Fayrouz Attia, Dalia Obeid, Hanan Almuzaini, Alaa Alzahrani, Jahan Salma, Iriya Fujitsuka, Abdullah M. Assiri, Dieter C. Broering, Raja Chinnappan, Ahmed Yaqinuddin, Tanveer Ahmad Mir   +13 more
doaj   +1 more source

Generation of Fibrotic Liver Organoids Using Hepatocytes, Primary Liver Sinusoidal Endothelial Cells, Hepatic Stellate Cells, and Macrophages

Cells, 2023
Liver organoids generated with single or multiple cell types have been used to investigate liver fibrosis development, toxicity, pathogenesis, and drug screening.
Yongdae Yoon, Seong Chan Gong, Moon Young Kim, Soon Koo Baik, Ju-Eun Hong, Ki-Jong Rhee, Hoon Ryu, Young Woo Eom   +7 more
doaj   +1 more source