Results 51 to 60 of about 19,245 (266)

Examining the gut-liver axis in liver cancer using organoid models

, 2021
The World Health Organization predicts that by 2030 liver cancer will cause 1 million deaths annually, thus becoming the third most lethal cancer worldwide.
Ahlenstiel, Golo (R18999), Shek, Dmitrii (S34338), Read, Scott A. (R19227), Chen, Dishen   +3 more
core   +1 more source

Current advances and prospects in biomaterials-guided tools for liver organoids research

Engineered Regeneration
Liver is the largest solid organ in the human body engaged in an array of critical physiological activities that primarily support metabolism, digestion, nutrient storage, detoxification.
Sana Ahmed, Eman Alshehri, Sarah Nazneen, Fayrouz Attia, Dalia Obeid, Hanan Almuzaini, Alaa Alzahrani, Jahan Salma, Iriya Fujitsuka, Abdullah M. Assiri, Dieter C. Broering, Raja Chinnappan, Ahmed Yaqinuddin, Tanveer Ahmad Mir   +13 more
doaj   +1 more source

A decade of liver organoids: Advances in disease modeling

Clinical and Molecular Hepatology, 2023
Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have been described.
Yue Liu, Jian-Ying Sheng, Chun-Fang Yang, Junjun Ding, Yun-Shen Chan   +4 more
openaire   +3 more sources

Liver-bone organoids reveal senescence-driven interorgan crosstalk

Bioactive Materials
The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication.
Yingting Zhang, Yue Li, Fuxiao Wang, Zhenglin Dong, Jian Wang, Yi Chen, Yinkun Fu, Yuheng Lu, Xinyu Bao, Yuxiao Lai, Yingying Jing, Jianhua Wang, Jianping Peng, Chao-Po Lin, Jiacan Su, Ming He   +15 more
doaj   +1 more source

Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes

Cells, 2021
Liver organoids (LOs) are receiving considerable attention for their potential use in drug screening, disease modeling, and transplantable constructs.
Ensieh Zahmatkesh, Mohammad Hossein Ghanian, Ibrahim Zarkesh, Zahra Farzaneh, Majid Halvaei, Zahra Heydari, Farideh Moeinvaziri, Amnah Othman, Marc Ruoß, Abbas Piryaei, Roberto Gramignoli, Saeed Yakhkeshi, Andreas Nüssler, Mustapha Najimi, Hossein Baharvand, Massoud Vosough   +15 more
doaj   +1 more source

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
The latest approach in tissue engineering techniques is the use of deselularized native organ as scaffolds for organ reconstruction. Scaffolds made from natural or synthetic matrix have many shortcomings in providing ideal extracellular matrix microstructure for cell proliferation and differentiation.
openaire   +3 more sources

Liver organoids and their application in liver cancer research

Regenerative Therapy
Liver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods. Looking for an effective platform for liver cancer study and drug screening is urgent and important.
Xinyu Song, Kaifei Hou, Hongyan Zhou, Jingyi Yang, Ting Cao, Jiayu Zhang   +5 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system

Open Biology, 2022
Hepatitis C virus (HCV) remains a global public health challenge with an estimated 71 million people chronically infected, with surges in new cases and no effective vaccine.
Vaishaali Natarajan, Camille R. Simoneau, Ann L. Erickson, Nathan L. Meyers, Jody L. Baron, Stewart Cooper, Todd C. McDevitt, Melanie Ott   +7 more
doaj   +1 more source

Organoids of liver diseases: From bench to bedside [PDF]

World Journal of Gastroenterology, 2019
Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, etc.
Wu, Li-Jun, Chen, Zi-Yan, Wang, Yi, Zhao, Jun-Gang, Xie, Xiao-Zai, Chen, Gang   +5 more
openaire   +2 more sources