Results 51 to 60 of about 847,151 (108)

A human liver organoid screening platform for DILI risk prediction. [PDF]

J Hepatol, 2023
Zhang CJ, Meyer SR, O'Meara MJ, Huang S, Capeling MM, Ferrer-Torres D, Childs CJ, Spence JR, Fontana RJ, Sexton JZ.   +9 more
europepmc   +1 more source

Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study [PDF]

BACKGROUND: Patient-derived intestinal organoids (PDIOs) show great potential as in vitro drug testing platform for personalised medicine in Cystic Fibrosis and oncology.
HIT-CF organoid study group
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Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures. [PDF]

Nat Commun, 2023
Yang ASP, Dutta D, Kretzschmar K, Hendriks D, Puschhof J, Hu H, Boonekamp KE, van Waardenburg Y, Chuva de Sousa Lopes SM, van Gemert GJ, de Wilt JHW, Bousema T, Clevers H, Sauerwein RW.   +13 more
europepmc   +1 more source

Optimized 3D Culture of Hepatic Cells for Liver Organoid Metabolic Assays. [PDF]

Cells, 2021
Gamboa CM, Wang Y, Xu H, Kalemba K, Wondisford FE, Sabaawy HE.   +5 more
europepmc   +1 more source

Flexible liver organoid-based assessment of metal–organic framework biocompatibility toward programmable organoid bioengineering

Metal–organic frameworks (MOFs) are emerging as versatile nanomaterials for biomedical applications owing to their high surface area, tunable porosity, and structural flexibility.
Shixiang Liu, Hongjie Chi, Xuan Zhang, Chenzhong Li, Sumin Bian, Li Chen, Nan Jiang, Hugo Vankelecom, Shiyi Tan   +8 more
core   +1 more source

Decreased Hepatic Nerve Fiber Innervation in Patients with Liver Cirrhosis

, 2020
Background/Aims: Hepatic nerve innervation plays important roles in hepatic metabolism and hemodynamic mechanisms. We compared the distribution patterns of hepatic nerves between normal livers and two liver diseases to elucidate the effects of liver ...
유권, 김태헌, 정규원
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A "systems medicine" approach to the study of non-alcoholic fatty liver disease

, 2015
The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among ...
Grieco, Antonio
core   +1 more source

A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles. [PDF]

J Extracell Vesicles, 2022
Nguyen VVT, Ye S, Gkouzioti V, van Wolferen ME, Yengej FY, Melkert D, Siti S, de Jong B, Besseling PJ, Spee B, van der Laan LJW, Horland R, Verhaar MC, van Balkom BWM.   +13 more
europepmc   +1 more source

Author Correction: Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density. [PDF]

Sci Rep, 2023
Torizal FG, Utami T, Lau QY, Inamura K, Nishikawa M, Sakai Y.   +5 more
europepmc   +1 more source

Organoid-ICLIP: Class imbalance-aware vision-language learning for organoid mitosis classification

Visual analysis of brain organoid imaging is critical for advancing the understanding of in vitro organoid development. However, precise differentiation of mitotic stages remains challenging due to complex cellular morphology and limited imaging data. To
Anabia Sohail (22171822), Oishi Deb (22067627), Anwaar Anwaar-Ul-Haq (17341168)   +2 more
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