Results 41 to 50 of about 18,518 (246)

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B., Marques, Vanda, van Mil, Saskia W.C., Rodrigues, Cecilia M.P.   +3 more
openaire   +2 more sources

Liver-bone organoids reveal senescence-driven interorgan crosstalk

Bioactive Materials
The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication.
Yingting Zhang, Yue Li, Fuxiao Wang, Zhenglin Dong, Jian Wang, Yi Chen, Yinkun Fu, Yuheng Lu, Xinyu Bao, Yuxiao Lai, Yingying Jing, Jianhua Wang, Jianping Peng, Chao-Po Lin, Jiacan Su, Ming He   +15 more
doaj   +1 more source

Reconstruction of liver organoid using a bioreactor

World Journal of Gastroenterology, 2006
To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver.We previously reported that a radial-flow bioreactor (RFB) could provide a three-dimensional high-density culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line (FLC-5) as ...
Masaya, Saito, Tomokazu, Matsuura, Takahiro, Masaki, Haruka, Maehashi, Keiko, Shimizu, Yoshiaki, Hataba, Tohru, Iwahori, Tetsuro, Suzuki, Filip, Braet   +8 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A decade of liver organoids: Advances in disease modeling

Clinical and Molecular Hepatology, 2023
Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have been described.
Yue Liu, Jian-Ying Sheng, Chun-Fang Yang, Junjun Ding, Yun-Shen Chan   +4 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Liver organoids and their application in liver cancer research

Regenerative Therapy
Liver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods. Looking for an effective platform for liver cancer study and drug screening is urgent and important.
Xinyu Song, Kaifei Hou, Hongyan Zhou, Jingyi Yang, Ting Cao, Jiayu Zhang   +5 more
openaire   +3 more sources

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
The latest approach in tissue engineering techniques is the use of deselularized native organ as scaffolds for organ reconstruction. Scaffolds made from natural or synthetic matrix have many shortcomings in providing ideal extracellular matrix microstructure for cell proliferation and differentiation.
openaire   +3 more sources

Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes

Cells, 2021
Liver organoids (LOs) are receiving considerable attention for their potential use in drug screening, disease modeling, and transplantable constructs.
Ensieh Zahmatkesh, Mohammad Hossein Ghanian, Ibrahim Zarkesh, Zahra Farzaneh, Majid Halvaei, Zahra Heydari, Farideh Moeinvaziri, Amnah Othman, Marc Ruoß, Abbas Piryaei, Roberto Gramignoli, Saeed Yakhkeshi, Andreas Nüssler, Mustapha Najimi, Hossein Baharvand, Massoud Vosough   +15 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source