Results 41 to 50 of about 19,245 (266)

Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids

Frontiers in Cell and Developmental Biology, 2021
The current organoid culture systems allow pluripotent and adult stem cells to self-organize to form three-dimensional (3D) structures that provide a faithful recapitulation of the architecture and function of in vivo organs.
Mingyang Chang, Mariia S. Bogacheva, Yan-Ru Lou   +2 more
doaj   +1 more source

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
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Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Cell Reports, 2017
Summary: Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges.
Takanori Takebe, Keisuke Sekine, Masaki Kimura, Emi Yoshizawa, Satoru Ayano, Masaru Koido, Shizuka Funayama, Noriko Nakanishi, Tomoko Hisai, Tatsuya Kobayashi, Toshiharu Kasai, Rina Kitada, Akira Mori, Hiroaki Ayabe, Yoko Ejiri, Naoki Amimoto, Yosuke Yamazaki, Shimpei Ogawa, Momotaro Ishikawa, Yasujiro Kiyota, Yasuhiko Sato, Kohei Nozawa, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi   +24 more
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Liver Organoids as an In Vitro Model to Study Primary Liver Cancer

International Journal of Molecular Sciences, 2023
Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide. Bi-dimensional in vitro models are unable to recapitulate the key features of PLC; consequently, recent advancements in three-dimensional in vitro systems, such as organoids, opened up ...
Silvia De Siervi, Cristian Turato
openaire   +3 more sources

Scalable production of tissue-like vascularized liver organoids from human PSCs

Experimental and Molecular Medicine, 2023
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver.
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, María Eugenia de la Morena-Barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Pérez, Henning Kempf, Kathrine S. Åsrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Frøydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan   +35 more
doaj   +1 more source

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B., Marques, Vanda, van Mil, Saskia W.C., Rodrigues, Cecilia M.P.   +3 more
openaire   +2 more sources

Gastric stem cell research and gastric organoids

, 2022
The stomach is a complex organ lined with ordered epithelium consisting of different adult stem cell (ASC) pools. In the previous decade, research into gastric epithelial stem cells has been performed using lineage tracing methods, and several putative ...
Haengdueng Jeong, Ki Taek Nam
core   +1 more source

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Communications Biology, 2021
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer.
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk   +16 more
doaj   +1 more source

Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges

Bioengineering
Hepatic cancer is widely regarded as the leading cause of cancer-related mortality worldwide. Despite recent advances in treatment options, the prognosis of liver cancer remains poor.
Abdullah Jabri, Jibran Khan, Bader Taftafa, Mohamed Alsharif, Abdulaziz Mhannayeh, Raja Chinnappan, Alaa Alzhrani, Shadab Kazmi, Mohammad Shabab Mir, Aljohara Waleed Alsaud, Ahmed Yaqinuddin, Abdullah M. Assiri, Khaled AlKattan, Yogesh K. Vashist, Dieter C. Broering, Tanveer Ahmad Mir   +15 more
doaj   +1 more source

Reconstruction of liver organoid using a bioreactor

World Journal of Gastroenterology, 2006
To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver.We previously reported that a radial-flow bioreactor (RFB) could provide a three-dimensional high-density culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line (FLC-5) as ...
Masaya, Saito, Tomokazu, Matsuura, Takahiro, Masaki, Haruka, Maehashi, Keiko, Shimizu, Yoshiaki, Hataba, Tohru, Iwahori, Tetsuro, Suzuki, Filip, Braet   +8 more
openaire   +2 more sources