Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis [PDF]
Stem Cell Reports, 2017 Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen +20 more
doaj +4 more sources
Mechano-modulatory synthetic niches for liver organoid derivation. [PDF]
Nat Commun, 2020 The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling.
Sorrentino G +6 more
europepmc +3 more sources
A human liver organoid screening platform for DILI risk prediction. [PDF]
J Hepatol, 2023 Background & Aims: Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes frequent morbidity, mortality, clinical trial failures and post-approval withdrawal.
Zhang CJ +9 more
europepmc +2 more sources
Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo models thus representing a turning point for studying liver disease modeling.
Caiazza C., Parisi S., Caiazzo M.
openaire +6 more sources
Progress in human liver organoids [PDF]
Journal of Molecular Cell Biology, 2020 AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
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Organoids for the Study of Liver Cancer
Seminars in Liver Disease, 2021 AbstractLiver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells have been applied to liver cancer research.
Wang, Haichuan +2 more
openaire +5 more sources
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies. [PDF]
Anal Chem, 2021 Liver organoids are emerging tools for precision drug development and toxicity screening. We demonstrate that electromembrane extraction (EME) based on electrophoresis across an oil membrane is suited for segregating selected organoid-derived drug ...
Skottvoll FS +13 more
europepmc +2 more sources
Optimized 3D Culture of Hepatic Cells for Liver Organoid Metabolic Assays. [PDF]
Cells, 2021 The liver is among the principal organs for glucose homeostasis and metabolism. Studies of liver metabolism are limited by the inability to expand primary hepatocytes in vitro while maintaining their metabolic functions.
Gamboa CM +5 more
europepmc +2 more sources
Human Multi-Lineage Liver Organoid Model Reveals Impairment of CYP3A4 Expression upon Repeated Exposure to Graphene Oxide [PDF]
CellsAlessio Romaldini +2 more
exaly +2 more sources
Liver Organoids: Recent Developments, Limitations and Potential [PDF]
Frontiers in Medicine, 2021 Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas.
Sean Philip Harrison +11 more
openaire +5 more sources