Results 21 to 30 of about 18,518 (246)

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

Cells, 2020
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Monique E. van Wolferen, Chen Chen, Sathidpak Nantasanti Assawarachan, Kerstin Schneeberger, Anne Kummeling, Giora van Straten, Ies C. Akkerdaas, Christel R. Vinke, Frank G. van Steenbeek, Leonie W.L. van Bruggen, Jeannette Wolfswinkel, Guy C.M. Grinwis, Sabine A. Fuchs, Helmuth Gehart, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +22 more
doaj   +1 more source

Liver Organoids: Recent Developments, Limitations and Potential [PDF]

Frontiers in Medicine, 2021
Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas.
Sean Philip Harrison, Sean Philip Harrison, Saphira Felicitas Baumgarten, Saphira Felicitas Baumgarten, Rajneesh Verma, Rajneesh Verma, Oleg Lunov, Alexandr Dejneka, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan   +11 more
openaire   +5 more sources

Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms [PDF]

PeerJ, 2020
Background The use of a personalized liver organoid derived from human-induced pluripotent stem cells (HuiPSCs) is advancing the use of in vitro disease models for the design of specific, effective therapies for individuals. Collecting patient peripheral
Kasem Kulkeaw, Alisa Tubsuwan, Nongnat Tongkrajang, Narisara Whangviboonkij   +3 more
doaj   +2 more sources

3D Co-Culture of Hepatocyte, a Hepatic Stellate Cell Line, and Stem Cells for Developing a Bioartificial Liver Prototype

International Journal of Technology, 2020
A liver organoid is an in vitro reconstruction of the liver that mimics the in vivo liver microstructure and performs liver functions. Liver organoids can be used for drug testing, as a model of liver disease pathogenesis, and as a bioartificial ...
Christine Verawaty Sibuea, Jeanne Pawitan, Radiana Antarianto, Cynthia O.M. Jasirwan, Imelda Rosalyn Sianipar, Evah Luviah, Retno Wahyu Nurhayati, Wildan Mubarok, Nuzli Fahdia Mazfufah   +8 more
doaj   +1 more source

Human Organoids for Predictive Toxicology Research and Drug Development

Frontiers in Genetics, 2021
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
doaj   +1 more source

A Chemically Defined Hydrogel for Human Liver Organoid Culture. [PDF]

Adv Funct Mater, 2020
AbstractEnd‐stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for regenerative medicine; however, organoids are currently cultured in Matrigel, which is ...
Ye S, Boeter JWB, Mihajlovic M, van Steenbeek FG, van Wolferen ME, Oosterhoff LA, Marsee A, Caiazzo M, Caiazzo M, van der Laan LJW, Penning LC, Vermonden T, Spee B, Schneeberger K.   +13 more
europepmc   +9 more sources

Biliary Atresia – emerging diagnostic and therapy opportunities

EBioMedicine, 2021
Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In this review, we describe recent progress in the understanding of liver development with a focus on cholangiocyte differentiation and how use of technical ...
Urban Lendahl, Vincent C.H. Lui, Patrick H.Y. Chung, Paul K.H. Tam   +3 more
doaj   +1 more source

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Cell Reports, 2017
Summary: Organoid technology provides a revolutionary paradigm toward therapy but has yet to be applied in humans, mainly because of reproducibility and scalability challenges.
Takanori Takebe, Keisuke Sekine, Masaki Kimura, Emi Yoshizawa, Satoru Ayano, Masaru Koido, Shizuka Funayama, Noriko Nakanishi, Tomoko Hisai, Tatsuya Kobayashi, Toshiharu Kasai, Rina Kitada, Akira Mori, Hiroaki Ayabe, Yoko Ejiri, Naoki Amimoto, Yosuke Yamazaki, Shimpei Ogawa, Momotaro Ishikawa, Yasujiro Kiyota, Yasuhiko Sato, Kohei Nozawa, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi   +24 more
doaj   +1 more source

Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids

Frontiers in Cell and Developmental Biology, 2021
The current organoid culture systems allow pluripotent and adult stem cells to self-organize to form three-dimensional (3D) structures that provide a faithful recapitulation of the architecture and function of in vivo organs.
Mingyang Chang, Mariia S. Bogacheva, Yan-Ru Lou   +2 more
doaj   +1 more source

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +2 more sources