Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Dong-Hun Woo +7 more
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Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Byoung-San Moon +3 more
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Lamination-based organoid spatially resolved transcriptomics technique for primary lung and liver organoid characterization [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaShaohua Ma, Sha Liao, Yongde Cai
exaly +2 more sources
Recent advances in multicellular human liver models [PDF]
, 2022 The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug ...
Youngmi Ji +5 more
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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Advanced human liver models for the assessment of drug-induced liver injury [PDF]
, 2022 Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Myung Jin Son +3 more
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Toward brain organoid-based precision medicine in neurodegenerative diseases [PDF]
, 2022 In recent years, the concept of precision medicine—an approach to developing personalized drugs for disease prevention or treatment—has emerged as an up-and-coming field in medical research.
Inhee Mook-Jung, Jong-Chan Park
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Therapeutic applications of three-dimensional organoid models in lung cancer [PDF]
, 2021 Lung cancer, which remains a major cause of mortality worldwide, is a histologically diverse condition and demonstrates substantial phenotypic and genomic diversity among individual patients, manifesting as both intertumoral and intratumoral ...
Yongki Hwang +9 more
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Construction of mouse liver aging model by hepatocyte organoid [PDF]
, 2023 Objective Construction of mouse liver senescence model induced rapidly in vitro by 3D organoid culture. Methods Mouse hepatocytes were collected by two-step perfusion method and cultured in 3D.
LU Yan, ZHOU Yabo, CHEN Jie
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Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments [PDF]
, 2022 Background Animal experiments have been performed to predict toxicity in humans in many fields, in-cluding toxicology, medicine, and pharmacology, and have contributed to increasing life ex-pectancy. However, animal testing has been a controversial issue
Seok-Ho Hong +7 more
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