Liver organoid culture methods. [PDF]
Cell Biosci, 2023 Organoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues.
Hu Y +10 more
europepmc +2 more sources
Amnion-Derived Mesenchymal Stromal/Stem Cell Paracrine Signals Potentiate Human Liver Organoid Differentiation: Translational Implications for Liver Regeneration [PDF]
Frontiers in Medicine, 2021 Mariangela Pampalone +2 more
exaly +2 more sources
Emerging liver organoid platforms and technologies. [PDF]
Cell Regen, 2021 Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs.
Lam DTUH, Dan YY, Chan YS, Ng HH.
europepmc +2 more sources
Recent advances and challenges in organoid-on-a-chip technology [PDF]
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
core +1 more source
Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]
, 2022 Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Jung-Hyun Kim +4 more
core +1 more source
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
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Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids [PDF]
, 2021 Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not
Dong-Hun Woo +3 more
core +1 more source
Human liver organoid: modeling liver steatosis and beyond. [PDF]
Cell Regen, 2023 Steatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention.
Wei J, Zhang W, Zhao B.
europepmc +2 more sources
Glioblastoma organoid technology: an emerging preclinical models for drug discovery [PDF]
, 2022 Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis.
Shuchang Zhou +3 more
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Progress, prospects, and limitations of organoid technology [PDF]
, 2022 Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs.
Jung Kyu Choi +2 more
core +1 more source