Results 11 to 20 of about 19,245 (266)

Organoids to model liver diseaseKey points [PDF]

JHEP Reports, 2021
Summary: The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and ...
Sandro Nuciforo, Markus H. Heim
doaj   +4 more sources

A Chemically Defined Hydrogel for Human Liver Organoid Culture. [PDF]

Adv Funct Mater, 2020
AbstractEnd‐stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for regenerative medicine; however, organoids are currently cultured in Matrigel, which is ...
Ye S, Boeter JWB, Mihajlovic M, van Steenbeek FG, van Wolferen ME, Oosterhoff LA, Marsee A, Caiazzo M, Caiazzo M, van der Laan LJW, Penning LC, Vermonden T, Spee B, Schneeberger K.   +13 more
europepmc   +12 more sources

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]

Front Cell Dev Biol
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH, Jung DJ, Han HJ, Son WC, Jeong GS.   +4 more
europepmc   +5 more sources

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

Stem Cell Research, 2014
Pancreatic Lgr5 expression has been associated with organoid-forming epithelial progenitor populations but the identity of the organoid-initiating epithelial cell subpopulation has remained elusive.
Craig Dorrell, Branden Tarlow, Yuhan Wang, Pamela S. Canaday, Annelise Haft, Jonathan Schug, Philip R. Streeter, Milton J. Finegold, Lincoln T. Shenje, Klaus H. Kaestner, Markus Grompe   +10 more
doaj   +2 more sources

Liver organoids: From fabrication to application in liver diseases

Frontiers in Physiology, 2022
As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu, Anqi Zeng, Zibo Liu, Chunjie Wu, Linjiang Song   +4 more
doaj   +3 more sources

Emerging biotechnologies for engineering liver organoids

Bioactive Materials
The engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao   +4 more
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Toward reproducible tumor organoid culture: focusing on primary liver cancer [PDF]

Frontiers in Immunology
Organoids present substantial potential for pushing forward preclinical research and personalized medicine by accurately recapitulating tissue and tumor heterogeneity in vitro.
Lianming Guo, Chao Li, Weiqiang Gong
doaj   +2 more sources

Liver organoids: an in vitro 3D model for liver cancer study

Cell & Bioscience, 2022
Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally ...
Renshun Dong, Bixiang Zhang, Xuewu Zhang
doaj   +3 more sources

Liver organoids: Current advances and future applications for hepatology [PDF]

Clinical and Molecular Hepatology
The creation of self-organizing liver organoids represents a significant, although modest, step toward addressing the ongoing organ shortage crisis in allogeneic liver transplantation.
Yohan Kim, Minseok Kang, Michael Girma Mamo, Michael Adisasmita, Meritxell Huch, Dongho Choi   +5 more
doaj   +2 more sources

Droplet-engineered organoids recapitulate parental tissue transcriptome with inter-organoid homogeneity and inter-tumor cell heterogeneity

Fundamental Research
Organoids are expected to function as effective human organ models for precision cancer studies and drug development. Currently, primary tissue-derived organoids, termed non-engineered organoids (NEOs), are produced by manual pipetting or liquid handling
Haoran Zhao, Yifan Cheng, Jiawei Li, Jiaqi Zhou, Haowei Yang, Feng Yu, Feihong Yu, Davit Khutsishvili, Zitian Wang, Shengwei Jiang, Kaixin Tan, Yi Kuang, Xinhui Xing, Shaohua Ma   +13 more
doaj   +2 more sources