Results 11 to 20 of about 18,518 (246)
Organoids to model liver diseaseKey points [PDF]
JHEP Reports, 2021 Summary: The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and ...
Sandro Nuciforo, Markus H. Heim
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Emerging biotechnologies for engineering liver organoids
Bioactive MaterialsThe engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao +4 more
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Liver organoids: From fabrication to application in liver diseases
Frontiers in Physiology, 2022 As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu +4 more
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Liver organoids: an in vitro 3D model for liver cancer study
Cell & Bioscience, 2022 Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally ...
Renshun Dong, Bixiang Zhang, Xuewu Zhang
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Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]
Front Cell Dev BiolBackground: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH +4 more
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Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo models thus representing a turning point for studying liver disease modeling.
Caiazza C., Parisi S., Caiazzo M.
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Progress in human liver organoids [PDF]
Journal of Molecular Cell Biology, 2020 AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
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Organoids for the Study of Liver Cancer
Seminars in Liver Disease, 2021 AbstractLiver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells have been applied to liver cancer research.
Wang, Haichuan +2 more
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Lamination-based organoid spatially resolved transcriptomics technique for primary lung and liver organoid characterization [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaShaohua Ma, Shaohua Ma, Sha Liao
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Human Multi-Lineage Liver Organoid Model Reveals Impairment of CYP3A4 Expression upon Repeated Exposure to Graphene Oxide [PDF]
CellsMarina Veronesi +2 more
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