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A new inject-embed 3D culture method enables the spheroid and aggregate formation from single or dual liver cancer cell types [PDF]
Cancer Cell InternationalBackground Three-dimensional (3D) cell culture techniques have emerged as a bridge between traditional two-dimensional (2D) cell culture and the complex 3D architecture of living organisms.
Hanyuan Zhang +9 more
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Validation of a novel perfusion bioreactor system in cancer research [PDF]
Hemijska Industrija, 2020 Development of drugs is a complex, time- and cost-consuming process due to the lack of standardized and reliable characterization techniques and models. Traditionally, drug screening is based on in vitro analysis using two-dimensional (2D) cell cultures ...
Stojkovska Jasmina +5 more
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Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms
Molecules, 2020 Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug ...
Agustín Cota-Coronado +4 more
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Negative regulation of CDKN1A by the histone methyltransferase EHMT2 for cell growth in colorectal cancer [PDF]
Organoid, 2022 Background Epigenetic regulation of oncogenes and tumor suppressor genes by histone methyltransferases is an important process for colon cancer growth and metastasis.
Kwangho Kim +3 more
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Cell culture models for SARS-CoV-2 infectivity and systemic complications [PDF]
Pharmaceutical Sciences Asia, 2022 COVID-19 was declared by WHO as a pandemic since March 2020. The vaccination program has been implemented worldwide. Specific antiviral drugs such as remdesivir, molnupiravir and ritonavir-based nirmatrelvir were effective against SARS-CoV-2 infection ...
Khanit Sa-ngiamsuntorn +3 more
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Marine Drugs, 2019 Plocabulin is a novel microtubule-disrupting antitumor agent of marine origin that is currently undergoing phase II clinical trials. Plocabulin has potent antiproliferative and antiangiogenic actions in carcinoma cell lines and has antitumor activity in ...
Alba Costales-Carrera +6 more
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Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
Nanomaterials, 2020 (1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures better than 2D cultures.
Elisabeth Elje +7 more
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Journal of Biomechanical Science and Engineering, 2009 The purpose of this study is to test a hypothesis that involvement of the low-magnitude, high frequency strain components in the walking-induced bone strain is essential to elicit the osteogenic response of osteoblasts to the bone strain.
Shigeo M. TANAKA, Hui B. SUN
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Journal of Biomechanical Science and Engineering, 2013 There is a demand for three-dimensional (3D) angiogenesis model including endothelial cells (ECs) and mesenchymal stem cells (MSCs), which are known to differentiate into pericytes, to construct stabilized and matured microvascular networks in vitro ...
Kyoko YAMAMOTO +8 more
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Intracellular Ca2+ Responses of 3D-Cultured Osteoblasts to Dynamic Loading
Journal of Biomechanical Science and Engineering, 2012 In bone cells, intracellular Ca2+ (iCa2+) functions as a second messenger in the mechanotransduction pathway. Its responses to mechanical stimulation can be observed microscopically on a rigid flat surface with a Ca2+ fluorescent indicator, generally ...
Shigeo M. TANAKA
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