Results 11 to 20 of about 5,851,651 (312)
Cells, 2020 Much interest has been directed towards stem cells, both in basic and translational research, to understand basic stem cell biology and to develop new therapies for many disorders.
Joni H. Ylostalo
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The challenge of ovarian tissue culture: 2D versus 3D culture [PDF]
Journal of Ovarian Research, 2021 Background Cryopreservation of ovarian tissue is a powerful technique for preserving female fertility, as it can restore fertility and endocrine function.
Ana Sofia Pais +6 more
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3D Culture of MSCs for Clinical Application. [PDF]
Bioengineering (Basel)Mesenchymal stem cells (MSCs) play an important role in regenerative medicine and drug discovery due to their multipotential differentiation capabilities and immunomodulatory effects. Compared with traditional 2D cultures of MSCs, 3D cultures of MSCs have emerged as an effective approach to enhance cell viability, proliferation, and functionality, and ...
Gao Q +10 more
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A new inject-embed 3D culture method enables the spheroid and aggregate formation from single or dual liver cancer cell types [PDF]
Cancer Cell InternationalBackground Three-dimensional (3D) cell culture techniques have emerged as a bridge between traditional two-dimensional (2D) cell culture and the complex 3D architecture of living organisms.
Hanyuan Zhang +9 more
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Validation of a novel perfusion bioreactor system in cancer research [PDF]
Hemijska Industrija, 2020 Development of drugs is a complex, time- and cost-consuming process due to the lack of standardized and reliable characterization techniques and models. Traditionally, drug screening is based on in vitro analysis using two-dimensional (2D) cell cultures ...
Stojkovska Jasmina +5 more
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Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms
Molecules, 2020 Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug ...
Agustín Cota-Coronado +4 more
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Negative regulation of CDKN1A by the histone methyltransferase EHMT2 for cell growth in colorectal cancer [PDF]
Organoid, 2022 Background Epigenetic regulation of oncogenes and tumor suppressor genes by histone methyltransferases is an important process for colon cancer growth and metastasis.
Kwangho Kim +3 more
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Cell culture models for SARS-CoV-2 infectivity and systemic complications [PDF]
Pharmaceutical Sciences Asia, 2022 COVID-19 was declared by WHO as a pandemic since March 2020. The vaccination program has been implemented worldwide. Specific antiviral drugs such as remdesivir, molnupiravir and ritonavir-based nirmatrelvir were effective against SARS-CoV-2 infection ...
Khanit Sa-ngiamsuntorn +3 more
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The Importance of Proper Oxygenation in 3D Culture [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Cell culture typically employs inexpensive, disposable plasticware, and standard humidified CO2/room air incubators (5% CO2, ∼20% oxygen). These methods have historically proven adequate for the maintenance of viability, function, and proliferation of many cell types, but with broad variation in culture practices.
Hubert M. Tse +4 more
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Marine Drugs, 2019 Plocabulin is a novel microtubule-disrupting antitumor agent of marine origin that is currently undergoing phase II clinical trials. Plocabulin has potent antiproliferative and antiangiogenic actions in carcinoma cell lines and has antitumor activity in ...
Alba Costales-Carrera +6 more
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