Results 1 to 10 of about 201,049 (120)

Isolation of Hepatocytes from Liver Tissue by a Novel, Semi-Automated Perfusion Technology

Biomedicines, 2022
Primary hepatocytes are a major tool in biomedical research. However, obtaining high yields of variable hepatocytes is technically challenging. Most protocols rely on the two-step collagenase perfusion protocol introduced by Per Ottar Seglen in 1976.
Carsten Poggel, Timo Adams, Ronald Janzen, Alexander Hofmann, Olaf Hardt, Elke Roeb, Sarah K. Schröder, Carmen G. Tag, Martin Roderfeld, Ralf Weiskirchen   +9 more
doaj   +1 more source

Effect of Annona muricata L. Leaf Ethanol Extract in CCl4 Hepatitis Rat Model

Althea Medical Journal, 2021
Background: Liver can be damaged by various factors, including the oxidative stress mechanism. This damage can be inhibited by the application of anti-oxidant. The Annona muricata L. leaf is known to have antioxidant properties.
Kuswinarti Kuswinarti, Ilham Asrori Azka, Dwi Prasetyo   +2 more
doaj   +1 more source

Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice

Frontiers in Immunology, 2022
Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most common clinical liver diseases. Although pyroptosis plays an important role in ALI, there is still a lack of effective clinical drugs related to this mechanism ...
Jie Wang, Ke Shi, Ning An, Shuaifei Li, Mei Bai, Xudong Wu, Yan Shen, Ronghui Du, Jingcai Cheng, Xuefeng Wu, Qiang Xu   +10 more
doaj   +1 more source

A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) are emerging mediators of intercellular communication in nonalcoholic steatohepatitis (NASH). Palmitate, a lipotoxic saturated fatty acid, activates hepatocellular endoplasmic reticulum stress, which has been demonstrated to ...
Yasuhiko Nakao, Yasuhiko Nakao, Masanori Fukushima, Masanori Fukushima, Amy S. Mauer, Chieh-Yu Liao, Anya Ferris, Anya Ferris, Debanjali Dasgupta, Debanjali Dasgupta, Carrie Jo Heppelmann, Patrick M. Vanderboom, Patrick M. Vanderboom, Mayank Saraswat, Mayank Saraswat, Mayank Saraswat, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, Akhilesh Pandey, K. Sreekumaran Nair, Alina M. Allen, Kazuhiko Nakao, Harmeet Malhi   +23 more
doaj   +1 more source

Liver regeneration in traditional Chinese medicine: advances and challenges

Regenerative Medicine Research, 2020
Liver diseases pose a serious problem for national health care system all over the world. Liver regeneration has profound impacts on the occurrence and development of various liver diseases, and it remains an extensively studied topic.
Zhang Feng, Wang Feixia, Liang Baoyu, Li Zhanghao, Shao Jiangjuan, Zhang Zili, Wang Shijun, Zheng Shizhong   +7 more
doaj   +1 more source

Serum amyloid A is not incorporated into HDL during HDL biogenesis[S]

Journal of Lipid Research, 2020
Liver-derived serum amyloid A (SAA) is present in plasma where it is mainly associated with HDL and from which it is cleared more rapidly than are the other major HDL-associated apolipoproteins.
Ailing Ji, Xuebing Wang, Victoria P. Noffsinger, Drew Jennings, Maria C. de Beer, Frederick C. de Beer, Lisa R. Tannock, Nancy R. Webb   +7 more
doaj   +1 more source

Comparative anatomical, histological, and histochemical study of liver in human and domestic rabbit [PDF]

Iraqi Journal of Veterinary Sciences, 2019
This study was conducted to compare the anatomical histological and histochemical structure of human liver with the liver of domestic rabbits to evaluate the quality of liver of rabbit to be used as a model of mammalian species in the experimental ...
Muna Al-Hamdany
doaj   +1 more source

Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production

Frontiers in Cell and Developmental Biology, 2021
Excessive accumulation of reactive oxygen species (ROS) is considered a major culprit for the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Fangqiao Lv, Tinghui Shao, Yujia Xue, Xiulian Miao, Yan Guo, Yutong Wang, Yong Xu, Yong Xu   +7 more
doaj   +1 more source

Clonorchis sinensis Granulin Promotes Malignant Transformation of Hepatocyte Through EGFR-Mediated RAS/MAPK/ERK and PI3K/Akt Signaling Pathways

Frontiers in Cellular and Infection Microbiology, 2021
The biological functions of growth factor, such as granulins, have been explored in parasites, and we elucidated that Clonorchis sinensis granulin (CsGRN) promoted the metastasis of hepatocellular carcinoma in our previous study.
Caiqin Wang, Caiqin Wang, Caiqin Wang, Caiqin Wang, Caiqin Wang, Qing He, Qing He, Qing He, Qing He, Yingxuan Yin, Yingxuan Yin, Yingxuan Yin, Yingxuan Yin, Yinjuan Wu, Yinjuan Wu, Yinjuan Wu, Yinjuan Wu, Xuerong Li, Xuerong Li, Xuerong Li, Xuerong Li   +20 more
doaj   +1 more source

Ultrastructural organization of liver hepatocytes of the Anglo-Nubian goat [PDF]

Veterinarski Glasnik, 2023
The aim of the study was to establish the ultrastructural organization of hepatocytes of the Anglo-Nubian goat. Livers of adult goats of the Anglo-Nubian breed served as the material for the study. The study was carried out using the electron microscopic
Prusakova Anna V., Zelenevskiy Nikolay V., Prusakov Aleksey V., Yashin Anatoly V., Ponamarev Vladimir S.   +4 more
doaj   +1 more source