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The Efficacy of the Hepatocyte Spheroids for Hepatocyte Transplantation [PDF]
Cell Transplantation, 2021 The safety and short-term efficacy of hepatocyte transplantation (HCTx) have been widely proven. However, issues such as reduced viability and/or function of hepatocytes, insufficient engraftment, and lack of a long-term effect have to be overcome for widespread application of HCTx. In this study, we evaluated hepatocyte spheroids (
Kazuaki Shibuya +5 more
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Hepatocyte transplantation [PDF]
American Journal of Transplantation, 2004 Numerous laboratory studies have shown that hepatocyte transplantation may serve as an alternative to organ transplantation for patients with life-threatening liver disease. Because of the successes of experimental hepatocyte transplantation, institutions have attempted to use this therapy in the clinic for the treatment of a variety of hepatic ...
Ira J, Fox, Jayanta, Roy-Chowdhury
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Isolation of Hepatocytes from Liver Tissue by a Novel, Semi-Automated Perfusion Technology
Biomedicines, 2022 Primary hepatocytes are a major tool in biomedical research. However, obtaining high yields of variable hepatocytes is technically challenging. Most protocols rely on the two-step collagenase perfusion protocol introduced by Per Ottar Seglen in 1976.
Carsten Poggel +9 more
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Effect of Annona muricata L. Leaf Ethanol Extract in CCl4 Hepatitis Rat Model
Althea Medical Journal, 2021 Background: Liver can be damaged by various factors, including the oxidative stress mechanism. This damage can be inhibited by the application of anti-oxidant. The Annona muricata L. leaf is known to have antioxidant properties.
Kuswinarti Kuswinarti +2 more
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Frontiers in Immunology, 2022 Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most common clinical liver diseases. Although pyroptosis plays an important role in ALI, there is still a lack of effective clinical drugs related to this mechanism ...
Jie Wang +10 more
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A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity
Frontiers in Cell and Developmental Biology, 2021 Extracellular vesicles (EVs) are emerging mediators of intercellular communication in nonalcoholic steatohepatitis (NASH). Palmitate, a lipotoxic saturated fatty acid, activates hepatocellular endoplasmic reticulum stress, which has been demonstrated to ...
Yasuhiko Nakao +23 more
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Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes [PDF]
Cell Transplantation, 2005 The use of hepatocytes that express liver-specific functions to develop an artificial liver is promising. Unfortunately, the loss of specialized liver functions (dedifferentiation) is still a major problem. Different techniques, such as collagen entrapment, spherical multicellular aggregates (spheroids), and coculture of hepatocytes with extracellular ...
Giovanni Ambrosino +5 more
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Liver regeneration in traditional Chinese medicine: advances and challenges
Regenerative Medicine Research, 2020 Liver diseases pose a serious problem for national health care system all over the world. Liver regeneration has profound impacts on the occurrence and development of various liver diseases, and it remains an extensively studied topic.
Zhang Feng +7 more
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Serum amyloid A is not incorporated into HDL during HDL biogenesis[S]
Journal of Lipid Research, 2020 Liver-derived serum amyloid A (SAA) is present in plasma where it is mainly associated with HDL and from which it is cleared more rapidly than are the other major HDL-associated apolipoproteins.
Ailing Ji +7 more
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Comparative anatomical, histological, and histochemical study of liver in human and domestic rabbit [PDF]
Iraqi Journal of Veterinary Sciences, 2019 This study was conducted to compare the anatomical histological and histochemical structure of human liver with the liver of domestic rabbits to evaluate the quality of liver of rabbit to be used as a model of mammalian species in the experimental ...
Muna Al-Hamdany
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