Results 11 to 20 of about 200,012 (263)

Dual Regulation of Tank Binding Kinase 1 by BRG1 in Hepatocytes Contributes to Reactive Oxygen Species Production

Frontiers in Cell and Developmental Biology, 2021
Excessive accumulation of reactive oxygen species (ROS) is considered a major culprit for the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Fangqiao Lv, Tinghui Shao, Yujia Xue, Xiulian Miao, Yan Guo, Yutong Wang, Yong Xu, Yong Xu   +7 more
doaj   +1 more source

Clonorchis sinensis Granulin Promotes Malignant Transformation of Hepatocyte Through EGFR-Mediated RAS/MAPK/ERK and PI3K/Akt Signaling Pathways

Frontiers in Cellular and Infection Microbiology, 2021
The biological functions of growth factor, such as granulins, have been explored in parasites, and we elucidated that Clonorchis sinensis granulin (CsGRN) promoted the metastasis of hepatocellular carcinoma in our previous study.
Caiqin Wang, Caiqin Wang, Caiqin Wang, Caiqin Wang, Caiqin Wang, Qing He, Qing He, Qing He, Qing He, Yingxuan Yin, Yingxuan Yin, Yingxuan Yin, Yingxuan Yin, Yinjuan Wu, Yinjuan Wu, Yinjuan Wu, Yinjuan Wu, Xuerong Li, Xuerong Li, Xuerong Li, Xuerong Li   +20 more
doaj   +1 more source

Ultrastructural organization of liver hepatocytes of the Anglo-Nubian goat [PDF]

Veterinarski Glasnik, 2023
The aim of the study was to establish the ultrastructural organization of hepatocytes of the Anglo-Nubian goat. Livers of adult goats of the Anglo-Nubian breed served as the material for the study. The study was carried out using the electron microscopic
Prusakova Anna V., Zelenevskiy Nikolay V., Prusakov Aleksey V., Yashin Anatoly V., Ponamarev Vladimir S.   +4 more
doaj   +1 more source

ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice

Journal of Lipid Research, 2005
The relative contributions of ACAT2 and LCAT to the cholesteryl ester (CE) content of VLDL and LDL were measured. ACAT2 deficiency led to a significant decrease in the percentage of CE (37.2 ± 2.1% vs.
Richard G. Lee, Ramesh Shah, Janet K. Sawyer, Robert L. Hamilton, John S. Parks, Lawrence L. Rudel   +5 more
doaj   +1 more source

Hepatocyte transplantation

Revista Española de Enfermedades Digestivas, 2019
We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days ...
Javier A, Cienfuegos, Fernando, Rotellar, Víctor, Valenti   +2 more
openaire   +2 more sources

Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B

Cell Transplantation, 2018
Instead of liver transplantation or liver-directed gene therapy, genetic liver diseases are expected to be treated effectively using liver tissue engineering technology.
Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi   +9 more
doaj   +1 more source

DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells

Stem Cell Reports, 2017
The irreversibility of developmental processes in mammalian cells has been challenged by rising evidence that de-differentiation of hepatocytes occurs in adult liver.
Chien-Wei Lee, Wei-Chih Huang, Hsien-Da Huang, Yi-Hsiang Huang, Jennifer H. Ho, Muh-Hwa Yang, Vincent W. Yang, Oscar K. Lee   +7 more
doaj   +1 more source

Exposure to Pfaffia glomerata causes oxidative stress and triggers hepatic changes

Brazilian Journal of Biology, 2023
Medicinal plant species are genetically engineered to obtain higher production of biomass and specific secondary metabolites, which can be used in the pharmaceutical industry.
F. C. R. Dias, M. C. Cupertino, P. G. Silva, E. L. Oliveira, L. C. M. Ladeira, S. L. P. Matta, W. C. Otoni, M. L. M. Gomes   +7 more
doaj   +1 more source

Indicators of exchange of bile pigments under the action of ecopathogenic factors on the organism and correction with liposomes [PDF]

The Ukrainian Biochemical Journal, 2014
High levels of anthropogenic impact on the environment requires a detailed study of the features of the influence of heavy metals and ionizing radiation on living organisms, and provides for the development and use of effective means of protecting the ...
D. O. Melnychuk, V. A. Grishchenko, S. P. Veselskiy   +2 more
doaj   +1 more source

Inhibition of calcium imbalance protects hepatocytes from vanadium exposure-induced inflammation by mediating mitochondrial-associated endoplasmic reticulum membranes in ducks

Poultry Science, 2023
: Vanadium (V) is an essential mineral element in animals, but excessive V can lead to many diseases, affecting the health of humans and animals. However, the molecular crosstalk between mitochondria-associated endoplasmic reticulum membranes (MAMs) and ...
Yiling Zhang, Guyue Li, Yanqing Zhao, Xueyan Dai, Mingwen Hu, Huabin Cao, Kai Huang, Fan Yang   +7 more
doaj   +1 more source