Results 11 to 20 of about 251,001 (160)
Impairing hepatocyte regeneration to determine the regenerative capacity of the biliary epithelium [PDF]
, 2018 Liver injury stimulates hepatocyte proliferation, regenerating the liver through self-replication. In cases where there is severe, repetitive, parenchymal damage, as seen in human chronic liver disease, hepatocyte mediated regeneration becomes impaired.
Raven, Alexander Philip
core +3 more sources
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis [PDF]
, 2021 Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation in developed liver are unclear. Here, we identified that increased expression of
Kim K. +13 more
core +2 more sources
The role of hepatocyte growth factor/scatter factor in hepatoblastoma and hepatocellular carcinoma progression [PDF]
, 2006 Hepatocyte growth factor/scatter factor (HGF/SF) is a ubiquitously expressed molecule that elicits pleiotropic functions on epithelial cells, including mitogenic, motogenic, differentiating, angiogenic, and morphogenic effects. The receptor for HGF/SF is
Grotegut, Stefan
core +1 more source
Cells, 2022 Autophagy performs essential cell functions in the liver through an intracellular lysosomal degradation process. Several studies have reported that autophagy deficiency can lead to liver injury, including hepatic fibrosis; however, the mechanisms ...
Hye-Young Seo +5 more
doaj +1 more source
eLife, 2019 Hepatocellular carcinoma (HCC) is a deadly human cancer associated with chronic inflammation. The cytosolic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC is unknown.
SM Nashir Udden +8 more
doaj +1 more source
Dynamics of Hepatitis B Virus Covalently Closed Circular DNA: A Mini-Review
Microorganisms, 2023 Eradication of cccDNA is an ideal goal of chronic hepatitis B (CHB) therapy. Understanding the changes in the cccDNA pool during therapy provides a basis for developing CHB treatment strategies.
Jie-Li Hu, Ai-Long Huang
doaj +1 more source
, 2023 Background: Hepatocyte growth factor is a cytokine secreted by the stromal cells in the tumor microenvironment. There is little information about the clinical significance of serum hepatocyte growth factor level in patients diagnosed with ...
Başbınar, Yasemin +25 more
core +1 more source
Journal of Lipid Research, 2005 The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein.
Steven L. Sabol +2 more
doaj +1 more source
Cell Transplantation, 2018 Instead of liver transplantation or liver-directed gene therapy, genetic liver diseases are expected to be treated effectively using liver tissue engineering technology.
Ryota Okamoto +9 more
doaj +1 more source
Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
Cells, 2023 Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis.
Dao-Xin Wang +8 more
doaj +1 more source