Results 21 to 30 of about 251,001 (160)

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression [PDF]

, 2022
Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained from 50
Pramudi Wijayasiri, Timothy J. Kendall, Aloysious D. Aravinthan, Alexander, Graeme J., Kaye, Philip, Wijayasiri, Pramudi, Graeme J. Alexander, Philip Kaye, Stuart Astbury, Kendall, Timothy J., Fiona Oakley, Kendall, Timothy J.; id_orcid, Aravinthan, Aloysious D., Oakley, Fiona, Astbury, Stuart   +14 more
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Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier

Adipocyte, 2019
Adipose tissue function in the regulation of lipemia is highly dependent on intestinal absorption of nutrients. Therefore the aim of the present study was the development and validation of an in vitro multiculture model allowing to measure intestinal ...
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

Structured Illumination Microscopy of Mitochondrial in Mouse Hepatocytes with an Improved Image Reconstruction Algorithm

Micromachines, 2023
In this paper, a structured illumination microscopy (SIM) image reconstruction algorithm combined with notch function (N-SIM) is proposed. This method suppresses the defocus signal in the imaging process by processing the low-frequency signal of the ...
Kai Hu, Xuejuan Hu, Ting He, Jingxin Liu, Shiqian Liu, Jiaming Zhang, Yadan Tan, Xiaokun Yang, Hengliang Wang, Yifei Liang, Jianze Ye   +10 more
doaj   +1 more source

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

Journal of Lipid Research, 2013
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low.
Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge   +16 more
doaj   +1 more source

Distinct roles of the IRE1α arm and PERK arm of unfolded protein response in arachidonic acid-induced ferroptosis in hepatocytes

Food Innovation and Advances, 2023
Ferroptosis is a distinct form of cell death that is driven by iron-dependent phospholipid peroxidation. Polyunsaturated fatty acids (PUFAs), particularly arachidonic acid (AA) and adrenal acid (AdA), are most prone to lipid peroxidation, which induces ...
Han Zhang, Kai Han, Shutao Yin, Lihong Fan, Hongbo Hu, Chong Zhao   +5 more
doaj   +1 more source

Gene Structure, cDNA Sequence, and mRNA Distribution [PDF]

, 1994
The rat HNF-3 (hepatocyte nuclear factor 3) gene family encodes three transcription factors known to be important in the regulation of gene expression in liver and lung.
Schütz, Günther, Kaestner, Klaus H., Hiemisch, Holger, Luckow, Bruno   +3 more
core   +1 more source

A novel pathway for lipid biosynthesis: the direct acylation of glycerol

Journal of Lipid Research, 2001
The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated.
Douglas P. Lee, Andrew S. Deonarine, Martin Kienetz, Quansheng Zhu, Monika Skrzypczak, Monroe Chan, Patrick C. Choy   +6 more
doaj   +1 more source

Liver Development, Regeneration, and Carcinogenesis [PDF]

, 2010
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described.
Ross, James A, Kung, Janet W C, Currie, Ian S, Stuart J. Forbes, Forbes, Stuart J, Janet W. C. Kung, Ian S. Currie, James A. Ross   +7 more
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Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release [PDF]

, 2015
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)This study was funded by the British Heart Foundation (RG/09/002/2642 to F.M.M.-B.) and the ...
Mauro, Claudio; id_orcid, Haas, Robert, Mauro, Claudio, Fu, Hongmei, Mauro, C, Nadkarni, S, Steinbruchel, Daniel A., Coe, D, Komarowska, Izabela, Cooper, Dianne, Bucy, Pat, Pitzalis, Costantino, Wang, G, Anderson, Graham, Fu, H, Wang, Guosu, Steinbruchel, DA, Breckenridge, Ross, Kishore, Madhav, Haas, R, Anderson, G, Lombardi, Giovanna, Komarowska, I, Kishore, M, Marelli-Berg, FM, Marelli-Berg, Federica M., Lombardi, G, Coe, David, Pitzalis, C, Cooper, D, Nadkarni, Suchita, Breckenridge, R, Bucy, P   +32 more
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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Molecular Therapy: Nucleic Acids, 2013
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to humans ...
Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope   +15 more
doaj   +1 more source