Results 51 to 60 of about 25,342 (266)

Liver organoids: an in vitro 3D model for liver cancer study

Cell & Bioscience, 2022
AbstractPrimary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally in 2015. Due to the lack of an effective model to study HBV-associated liver carcinogenesis,
Renshun Dong, Bixiang Zhang, Xuewu Zhang
openaire   +3 more sources

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Advanced Science, 2022
Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is characterized by the dynamic interplay among different organs. The increasing incidence of T2DM reflects an urgent need for the development of in vitro human‐relevant
Tingting Tao, Pengwei Deng, Yaqing Wang, Xu Zhang, Yaqiong Guo, Wenwen Chen, Jianhua Qin   +6 more
doaj   +1 more source

Human liver organoids for disease modeling of fibrolamellar carcinoma

, 2022
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models.
Lalazar, Gadi, Torbenson, Michael S, Narayan, Nicole J.C., Clevers, Hans, LaQuaglia, Michael P., Requena, David, Ng, Denise, Narayan, Nicole J C, Hammond, William J, Ramos-Espiritu, Lavoisier, Shebl, Bassem, Wang, Ruisi, Levin, Solomon, Gehart, Helmuth, Simon, Sanford M., Simon, Sanford M, Hammond, William J., LaQuaglia, Michael P, Saltsman, James A, Saltsman, James A., Torbenson, Michael S.   +20 more
core   +1 more source

Quantitative Lipid Profiling Reveals Major Differences between Liver Organoids with Normal Pi*M and Deficient Pi*Z Variants of Alpha-1-antitrypsin [PDF]

, 2023
Different mutations in the SERPINA1 gene result in alpha-1 antitrypsin (AAT) deficiency and in an increased risk for the development of liver diseases. More than 90% of severe deficiency patients are homozygous for Z (Glu342Lys) mutation.
Gil-Marín, Sara, Garfia Castillo, María Cristina, Gómez Mariano, Gema, Loreto Hierro, Jaanam Lalchandani, Gomez-Mariano, Gema Maria, Martinez-Delgado, Beatriz, Sara Monzón, Gema Gomez-Mariano, Sara Pérez-Luz, Isabel Cuesta, Ramos Del Saz, Sheila, Iago Justo, Cristina Garfia, Monzón, Sara, Beatriz Martínez-Delgado, Gil-Martín, Sara, Varona Fernandez, Sarai, Janciauskiene, Sabina, Saz, Sheila Ramos-Del, Monzon-Fernandez, Sara, Maria Jose Barrero, Marcacuzco, Alberto, Ramos-Del Saz, Sheila, Justo Alonso, Iago, Sabina Janciauskiene, Alberto Marcacuzco, Pérez Luz, Sara, Barrero, Maria, Barrero, Maria Jose, Martínez Delgado, Beatriz, Gomez-Mariano, Gema, Marcacuzco Quinto, Alberto Alejandro, Varona, Sarai, Garfia, Cristina, Justo, Iago, Cuesta, Isabel, Sara Gil-Martín, Hierro, Loreto, Matamala, Nerea, Cuesta de la Plaza, Isabel, Nerea Matamala, Sheila Ramos-Del Saz, Sarai Varona, Perez-Luz, Sara, Lalchandani, Jaanam   +45 more
core   +1 more source

Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations. [PDF]

Commun Biol
Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (including strokes ...
Zdyrski C, Gabriel V, Gessler TB, Ralston A, Sifuentes-Romero I, Kundu D, Honold S, Wickham H, Topping NE, Sahoo DK, Bista B, Tamplin J, Ospina O, Piñeyro P, Arriaga M, Galan JA, Meyerholz DK, Allenspach K, Mochel JP, Valenzuela N.   +19 more
europepmc   +2 more sources

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B., Marques, Vanda, van Mil, Saskia W.C., Rodrigues, Cecilia M.P.   +3 more
openaire   +2 more sources

Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Technology in Cancer Research & Treatment, 2023
Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspase 9 (CRISPR ...
Wan Jeon MD, Se Yeon Jung PhD, Chae Young Lee PhD, Won-Tae Kim PhD, Hyun Kim PhD, Kyoung Won Jang PhD, Heuijin Lim PhD, Manwoo Lee PhD, Dong Hyeok Jeong PhD, Sung Dae Kim PhD, In Ah Kim PhD, MD, Si Ho Choi PhD, Tae Gen Son PhD, Kyung Su Kim PhD, MD   +13 more
doaj   +1 more source

Bio-engineering vascularised liver organoids

, 2022
© 2022 Kiryu Kee Loong YapLiver organoids are bioengineered constructs that recapitulate native liver tissue, and are used to study liver development, test drugs, and as replacement tissue that can be transplanted to treat liver disease.
Yap, Kiryu Kee Loong
core  

Reconstruction of liver organoid using a bioreactor

World Journal of Gastroenterology, 2006
To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver.We previously reported that a radial-flow bioreactor (RFB) could provide a three-dimensional high-density culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line (FLC-5) as ...
Masaya, Saito, Tomokazu, Matsuura, Takahiro, Masaki, Haruka, Maehashi, Keiko, Shimizu, Yoshiaki, Hataba, Tohru, Iwahori, Tetsuro, Suzuki, Filip, Braet   +8 more
openaire   +2 more sources

The application of liver cancer organoids in tumour precision medicine: A comprehensive review

iLIVER
Liver cancer is a leading cause of cancer-related death worldwide, and its complexity and heterogeneity pose considerable challenges to conventional treatment.
Jiaye Mo, Da Gong, Mei Zhai, Jintao Yang, Zhike Li, Meilong Wu, Xuesong Deng, Xiaoyong Dai   +7 more
doaj   +1 more source