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Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation

open access: yesCell Death and Disease, 2021
Tumour metastasis is the main cause of postoperative tumour recurrence and mortality in patients with hepatocellular carcinoma (HCC), but the underlying mechanism remains unclear.
Bo Sun   +6 more
doaj   +1 more source

Expert consensus on precision detection of intrahepatic cholangiocarcinoma (2024 edition)

open access: yesZhongguo Linchuang Yixue
Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous tumor, and molecular profiling serves as the foundation for personalized treatment of ICC.
Pathology Group, Chinese Society of Liver Cancer of Chinese Anti-Cancer Association; Liver Pathology Group, Chinese Society of Pathology of Chinese Anti-Cancer Association; Tumor Pathology Committee of Shanghai Anti-Cancer Association, Shanghai 200032, China
doaj   +1 more source

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma

open access: yesExperimental Hematology & Oncology, 2021
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9), one of the key enzymes in the process of lipid transport, is involved in the disease progression of various types of tumors.
Shi-Zhe Zhang   +6 more
doaj   +1 more source

Laparoscopic vs. Open Repeat Hepatectomy for Recurrent Liver Tumors: A Propensity Score–Matched Study and Meta-Analysis

open access: yesFrontiers in Oncology, 2021
Background: It remains unclear whether the short-term benefits of laparoscopic repeat hepatectomy (LRH) accrue to patients with recurrent liver tumors. The present study aimed to report our own center's experience and perform a meta-analysis to evaluate ...
Jia-Feng Chen   +15 more
doaj   +1 more source

Stemness in Liver Cancer [PDF]

open access: yesDigestive Diseases, 2017
Cancer cells possessing “stemness,” or stem-cell properties, are referred to as cancer stem cells (CSC) or cancer-initiating cells. The concept that these cells rest at the apex of the cancer hierarchy is an evolving theme in cancer research. These cells are by definition primarily responsible for the initiation and propagation of tumors as well as ...
openaire   +2 more sources

Circulating tumor cell detection and single‐cell analysis using an integrated workflow based on ChimeraX®‐i120 Platform: A prospective study

open access: yesMolecular Oncology, 2021
Circulating tumor cell (CTC) analysis holds great potential to be a noninvasive solution for clinical cancer management. A complete workflow that combined CTC detection and single‐cell molecular analysis is required.
Peng‐Xiang Wang   +16 more
doaj   +1 more source

Cancer of the Liver [PDF]

open access: yesThe American Journal of the Medical Sciences
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openaire   +2 more sources

Development and validation of a new tumor-based gene signature predicting prognosis of HBV/HCV-included resected hepatocellular carcinoma patients

open access: yesJournal of Translational Medicine, 2019
Background Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge to determine patients’ prognosis. We aim to identify new prognostic markers for resected HCC patients.
Gui-Qi Zhu   +13 more
doaj   +1 more source

Aflatoxin and liver cancer

open access: yesBest Practice & Research Clinical Gastroenterology, 1999
This chapter reviews the data that have been accumulated implicating aflatoxin ingestion as an important risk factor in the aetiology of hepatocellular carcinoma (HCC). Numerous epidemiological studies have observed a correlation between areas of high aflatoxin exposure and a high incidence of HCC. The use of experimental models and specific biomarkers
P E, Jackson, J D, Groopman
openaire   +2 more sources

MicroRNA and liver cancer

open access: yesCancer Drug Resistance, 2020
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. HCC is characterized by a poor prognosis and an ever increasing number of scientific studies aim to find new diagnostic, prognostic, and therapeutic targets. MicroRNAs (miRNAs), small non-coding RNAs that regulate the gene expression in many processes, have been shown ...
Onishi, Masaya   +2 more
openaire   +3 more sources

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