Results 41 to 50 of about 26,317 (246)

Liver Organoids as an In Vitro Model to Study Primary Liver Cancer

International Journal of Molecular Sciences, 2023
Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide. Bi-dimensional in vitro models are unable to recapitulate the key features of PLC; consequently, recent advancements in three-dimensional in vitro systems, such as organoids, opened up ...
Silvia De Siervi, Cristian Turato
openaire   +3 more sources

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Stem Cell Research, 2018
Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture ...
Jon N. Buzzelli, Djamila Ouaret, Graham Brown, Philip D. Allen, Ruth J. Muschel   +4 more
doaj   +1 more source

Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Technology in Cancer Research & Treatment, 2023
Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspase 9 (CRISPR ...
Wan Jeon MD, Se Yeon Jung PhD, Chae Young Lee PhD, Won-Tae Kim PhD, Hyun Kim PhD, Kyoung Won Jang PhD, Heuijin Lim PhD, Manwoo Lee PhD, Dong Hyeok Jeong PhD, Sung Dae Kim PhD, In Ah Kim PhD, MD, Si Ho Choi PhD, Tae Gen Son PhD, Kyung Su Kim PhD, MD   +13 more
doaj   +1 more source

Reconstruction of liver organoid using a bioreactor

World Journal of Gastroenterology, 2006
To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver.We previously reported that a radial-flow bioreactor (RFB) could provide a three-dimensional high-density culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line (FLC-5) as ...
Masaya, Saito, Tomokazu, Matsuura, Takahiro, Masaki, Haruka, Maehashi, Keiko, Shimizu, Yoshiaki, Hataba, Tohru, Iwahori, Tetsuro, Suzuki, Filip, Braet   +8 more
openaire   +2 more sources

The application of liver cancer organoids in tumour precision medicine: A comprehensive review

iLIVER
Liver cancer is a leading cause of cancer-related death worldwide, and its complexity and heterogeneity pose considerable challenges to conventional treatment.
Jiaye Mo, Da Gong, Mei Zhai, Jintao Yang, Zhike Li, Meilong Wu, Xuesong Deng, Xiaoyong Dai   +7 more
doaj   +1 more source

Cellular expansion of hepatocellular carcinoma organoids using decellularized liver scaffolds

Clinical Transplantation and Research
Background : A decellularized liver scaffold (DLS) is a three-dimensional acellular extracellular matrix created by removing cellular components from liver tissue. Hepatocellular carcinoma (HCC) organoids represent a useful experimental model.
Shin Hwang, I-Ji Jung, Kyoung-Jin Lee, Yun-Kyu Kim, Eunyoung Tak   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B., Marques, Vanda, van Mil, Saskia W.C., Rodrigues, Cecilia M.P.   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
The latest approach in tissue engineering techniques is the use of deselularized native organ as scaffolds for organ reconstruction. Scaffolds made from natural or synthetic matrix have many shortcomings in providing ideal extracellular matrix microstructure for cell proliferation and differentiation.
openaire   +3 more sources