Results 41 to 50 of about 25,342 (266)

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Stem Cell Reports, 2017
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +20 more
doaj   +1 more source

Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids. [PDF]

Hepatobiliary Surg Nutr
Zhang K, Yang H.
europepmc   +3 more sources

Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies [PDF]

, 2021
There is a need for long-lived hepatic in vitro models to better predict drug induced liver injury (DILI). Human liver-derived epithelial organoids are a promising cell source for advanced in vitro models.
Kerstin Schneeberger, Bouwmeester, Manon C., Buchholz, Maj-Britt, Kramer, Nynke I., Paulina N. Bernal, van der Laan, Luc J W, Loes A. Oosterhoff, van der Laan, Luc J.W.; id_orcid, Malda, Jos, Spee, Bart, Levato, Riccardo, Maj‐Britt Buchholz, Quentin C. Peiffer, Bernal, Paulina N., Riccardo Levato, van Wolferen, Monique E., Peiffer, Quentin C., van der Laan, Luc J.W., Jos Malda, Kramer, Nynke I, Manon C. Bouwmeester, Vermaas, Monique, Peiffer, Quentin, Bart Spee, Monique Vermaas, Nynke I. Kramer, Bernal, Paulina Nunez, Oosterhoff, Loes A, Lehmann, Vivian, Luc J. W. van der Laan, Oosterhoff, Loes A., Schneeberger, Kerstin, Vivian Lehmann, Monique E. van Wolferen, Buchholz, Maj Britt, van Wolferen, Monique, Bouwmeester, Manon C   +36 more
core   +2 more sources

Three-Dimensional Organoids as a Model to Study Nonalcoholic Fatty Liver Disease

, 2022
Despite the rising prevalence of nonalcoholic fatty liver disease (NAFLD), the underlying disease pathophysiology remains unclear. There is a great need for an efficient and reliable "human" in vitro model to study NAFLD and the progression to ...
Thadasina, Deepthi, Francis, Heather, Li, Ping, Isidan, Abdulkadir, Zhang, Wenjun, Kennedy, Lindsey, Cross-Najafi, Arthur A., Ekser, Burcin, Park, Yujin, Bolujo, Ifeoluwa, Alpini, Gianfranco, Sato, Keisaku, Lopez, Kevin, Dahlem, Andrew M.   +13 more
core   +1 more source

Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model

Cell Transplantation, 2020
Transplantation of liver organoids has been investigated as a treatment alternative to liver transplantation for chronic liver disease. Transportal approach can be considered as a method of delivering organoids to the liver.
Tomonori Tsuchida, Soichiro Murata, Shunsuke Hasegawa, Satoshi Mikami, Shin Enosawa, Huai-Che Hsu, Akinari Fukuda, Satoshi Okamoto, Akihiro Mori, Megumi Matsuo, Yumi Kawakatsu, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Hideki Taniguchi   +14 more
doaj   +1 more source

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]

Front Cell Dev Biol
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH, Jung DJ, Han HJ, Son WC, Jeong GS.   +4 more
europepmc   +4 more sources

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +2 more sources

Human liver organoids are susceptible to Plasmodium vivax infection. [PDF]

Malar J
Background The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver.
Nitaramorn N, Kobpornchai P, Tongkrajang N, Chaisri U, Imwong M, Kulkeaw K.   +5 more
europepmc   +2 more sources

Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling

Scientific Reports, 2023
Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems.
Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Jaeseo Lee, Hyun-Soo Cho, Dae-Soo Kim, Kyung-Sook Chung, Myung Jin Son   +7 more
doaj   +1 more source

Generation, Maintenance and HBV Infection of Human Liver Organoids [PDF]

, 2022
Hepatitis B virus (HBV) infection represents a major public health problem infecting approximately 400 million people worldwide. Despite the availability of a preventive vaccine and anti-viral therapies, chronic HBV infection remains a major health issue
Mahmoudi, Tokameh, Hossain, Tanvir, Romal, Shahla   +2 more
core   +1 more source