Results 41 to 50 of about 24,091 (241)

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +2 more sources

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Advanced Science, 2022
Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is characterized by the dynamic interplay among different organs. The increasing incidence of T2DM reflects an urgent need for the development of in vitro human‐relevant
Tingting Tao, Pengwei Deng, Yaqing Wang, Xu Zhang, Yaqiong Guo, Wenwen Chen, Jianhua Qin   +6 more
doaj   +1 more source

Liver organoids: an in vitro 3D model for liver cancer study

Cell & Bioscience, 2022
AbstractPrimary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally in 2015. Due to the lack of an effective model to study HBV-associated liver carcinogenesis,
Renshun Dong, Bixiang Zhang, Xuewu Zhang
openaire   +3 more sources

Liver Organoids as an In Vitro Model to Study Primary Liver Cancer

International Journal of Molecular Sciences, 2023
Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide. Bi-dimensional in vitro models are unable to recapitulate the key features of PLC; consequently, recent advancements in three-dimensional in vitro systems, such as organoids, opened up ...
Silvia De Siervi, Cristian Turato
openaire   +3 more sources

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Stem Cell Research, 2018
Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture ...
Jon N. Buzzelli, Djamila Ouaret, Graham Brown, Philip D. Allen, Ruth J. Muschel   +4 more
doaj   +1 more source

Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Technology in Cancer Research & Treatment, 2023
Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspase 9 (CRISPR ...
Wan Jeon MD, Se Yeon Jung PhD, Chae Young Lee PhD, Won-Tae Kim PhD, Hyun Kim PhD, Kyoung Won Jang PhD, Heuijin Lim PhD, Manwoo Lee PhD, Dong Hyeok Jeong PhD, Sung Dae Kim PhD, In Ah Kim PhD, MD, Si Ho Choi PhD, Tae Gen Son PhD, Kyung Su Kim PhD, MD   +13 more
doaj   +1 more source

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B., Marques, Vanda, van Mil, Saskia W.C., Rodrigues, Cecilia M.P.   +3 more
openaire   +2 more sources

The application of liver cancer organoids in tumour precision medicine: A comprehensive review

iLIVER
Liver cancer is a leading cause of cancer-related death worldwide, and its complexity and heterogeneity pose considerable challenges to conventional treatment.
Jiaye Mo, Da Gong, Mei Zhai, Jintao Yang, Zhike Li, Meilong Wu, Xuesong Deng, Xiaoyong Dai   +7 more
doaj   +1 more source

Reconstruction of liver organoid using a bioreactor

World Journal of Gastroenterology, 2006
To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver.We previously reported that a radial-flow bioreactor (RFB) could provide a three-dimensional high-density culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line (FLC-5) as ...
Masaya, Saito, Tomokazu, Matsuura, Takahiro, Masaki, Haruka, Maehashi, Keiko, Shimizu, Yoshiaki, Hataba, Tohru, Iwahori, Tetsuro, Suzuki, Filip, Braet   +8 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source