Results 21 to 30 of about 25,342 (266)
Use of organoids technology on study of liver malignancy [PDF]
Indian Journal of Medical and Paediatric Oncology, 2018 The study on liver cancer has been performed in clinical medicine and medical science for a long time. Within the few recent years, there are many new emerging biomedical technologies that help better assess on the liver cancer.
Beuy Joob, Viroj Wiwanitkit
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Liver-bone organoids reveal senescence-driven interorgan crosstalk
Bioactive MaterialsThe liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication.
Yingting Zhang +15 more
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Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation [PDF]
BMC BiologyBackground Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation.
Shaoyu Zhong +7 more
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Generation of in vivo-like multicellular liver organoids by mimicking developmental processes: A review [PDF]
Regenerative TherapyLiver is involved in metabolic reactions, ammonia detoxification, and immunity. Multicellular liver tissue cultures are more desirable for drug screening, disease modeling, and researching transplantation therapy, than hepatocytes monocultures ...
Ayumu Okumura +2 more
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Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review
Transplant InternationalLiver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss.
C. Rejas, H. Junger
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Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases [PDF]
BiomedicinesLiver organoids take advantage of several important features of pluripotent stem cells that self-assemble in a three-dimensional culture matrix and reproduce many aspects of the complex organization found within their native tissue or organ counterparts.
Dalia A. Obeid +11 more
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Progress in human liver organoids [PDF]
Journal of Molecular Cell Biology, 2020 AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
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Animal and Organoid Models of Liver Fibrosis [PDF]
Frontiers in Physiology, 2021 Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver.
Yu-long Bao +10 more
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Emerging liver organoid platforms and technologies [PDF]
Cell Regeneration, 2021 AbstractBuilding human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism.
Do Thuy Uyen Ha Lam +3 more
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Liver organoid culture methods
Cell & Bioscience, 2023 AbstractOrganoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids have been developed rapidly, and their applications in biomedicine, such as drug screening, disease modeling, and regenerative medicine ...
Yiqing Hu +10 more
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