Results 21 to 30 of about 24,091 (241)
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj +1 more source
Emerging liver organoid platforms and technologies [PDF]
Cell Regeneration, 2021 AbstractBuilding human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism.
Do Thuy Uyen Ha Lam +3 more
openaire +3 more sources
Liver organoid culture methods
Cell & Bioscience, 2023 AbstractOrganoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids have been developed rapidly, and their applications in biomedicine, such as drug screening, disease modeling, and regenerative medicine ...
Yiqing Hu +10 more
openaire +3 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Human pluripotent stem cell-derived liver organoids are emerging as more human-relevant in vitro models for studying liver diseases and hepatotoxicity than traditional hepatocyte cultures and animal models.
Xiaodong Xu +9 more
doaj +1 more source
Organoids for the Study of Liver Cancer
Seminars in Liver Disease, 2021 AbstractLiver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells have been applied to liver cancer research.
Wang, Haichuan +2 more
openaire +5 more sources
Organoid transplant approaches for the liver
Transplant International, 2021 Organoid technology is a state-of-the-art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver.
Hasan Al, Reza +2 more
openaire +2 more sources
Cells, 2023 Liver organoids generated with single or multiple cell types have been used to investigate liver fibrosis development, toxicity, pathogenesis, and drug screening.
Yongdae Yoon +7 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C).
Patrick Ho-Yu Chung +5 more
doaj +1 more source
iScience, 2023 Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses ...
Jong-Hwan Kim +4 more
doaj +1 more source
Engineering the Vasculature of Stem-Cell-Derived Liver Organoids
Biomolecules, 2021 The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and ...
Xv Zhang, Liling Tang, Qian Yi
doaj +1 more source