Results 11 to 20 of about 26,317 (246)
A decade of liver organoids: Advances in disease modeling [PDF]
Clinical and Molecular Hepatology, 2023 Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have ...
Yue Liu +4 more
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Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza +2 more
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Liver organoids: From fabrication to application in liver diseases
Frontiers in Physiology, 2022 As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu +4 more
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Updates on Organoid Model for the Study of Liver Cancer
Technology in Cancer Research & Treatment, 2023 Liver cancer remains one of the most common cancers worldwide with limited therapy options. The main risk factors for hepatocellular carcinoma (HCC), the most common form of liver cancer, include chronic infection with hepatitis B or hepatitis C viruses,
Korri E. El-Khobar PhD +1 more
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Bioengineering Liver Organoids for Diseases Modelling and Transplantation
Bioengineering, 2022 Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications.
Junzhi Li +5 more
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Liver organoids and their application in liver cancer research
Regenerative TherapyLiver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods.
Xinyu Song +5 more
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Use of organoids technology on study of liver malignancy [PDF]
Indian Journal of Medical and Paediatric Oncology, 2018 The study on liver cancer has been performed in clinical medicine and medical science for a long time. Within the few recent years, there are many new emerging biomedical technologies that help better assess on the liver cancer.
Beuy Joob, Viroj Wiwanitkit
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Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review
Transplant InternationalLiver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss.
C. Rejas, H. Junger
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Progress in human liver organoids [PDF]
Journal of Molecular Cell Biology, 2020 AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
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Emerging liver organoid platforms and technologies [PDF]
Cell Regeneration, 2021 AbstractBuilding human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism.
Do Thuy Uyen Ha Lam +3 more
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