Results 11 to 20 of about 25,342 (266)
Liver organoids and their application in liver cancer research [PDF]
Regenerative TherapyLiver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods.
Xinyu Song +5 more
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Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza +2 more
doaj +9 more sources
Organoids for the Study of Liver Cancer [PDF]
Seminars in Liver Disease, 2021 Liver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells
Chen, Xin +3 more
core +6 more sources
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj +2 more sources
Cells, 2023 Liver organoids generated with single or multiple cell types have been used to investigate liver fibrosis development, toxicity, pathogenesis, and drug screening.
Yongdae Yoon +7 more
doaj +2 more sources
A decade of liver organoids: Advances in disease modeling [PDF]
Clinical and Molecular Hepatology, 2023 Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have ...
Yue Liu +4 more
doaj +3 more sources
Liver organoids: From fabrication to application in liver diseases
Frontiers in Physiology, 2022 As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu +4 more
doaj +3 more sources
Updates on Organoid Model for the Study of Liver Cancer
Technology in Cancer Research & Treatment, 2023 Liver cancer remains one of the most common cancers worldwide with limited therapy options. The main risk factors for hepatocellular carcinoma (HCC), the most common form of liver cancer, include chronic infection with hepatitis B or hepatitis C viruses,
Korri E. El-Khobar PhD +1 more
doaj +3 more sources
Liver Organoids as an In Vitro Model to Study Primary Liver Cancer
International Journal of Molecular Sciences, 2023 Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide.
Silvia De Siervi, Cristian Turato
core +5 more sources
Stem Cell Research, 2018 Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture ...
Jon N. Buzzelli +4 more
doaj +3 more sources