Results 61 to 70 of about 25,342 (266)

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
The latest approach in tissue engineering techniques is the use of deselularized native organ as scaffolds for organ reconstruction. Scaffolds made from natural or synthetic matrix have many shortcomings in providing ideal extracellular matrix microstructure for cell proliferation and differentiation.
openaire   +3 more sources

Cellular expansion of hepatocellular carcinoma organoids using decellularized liver scaffolds

Clinical Transplantation and Research
Background : A decellularized liver scaffold (DLS) is a three-dimensional acellular extracellular matrix created by removing cellular components from liver tissue. Hepatocellular carcinoma (HCC) organoids represent a useful experimental model.
Shin Hwang, I-Ji Jung, Kyoung-Jin Lee, Yun-Kyu Kim, Eunyoung Tak   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Chemically Defined Hydrogel for Human Liver Organoid Culture [PDF]

Advanced Functional Materials, 2020
AbstractEnd‐stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for regenerative medicine; however, organoids are currently cultured in Matrigel, which is ...
Ye S., Boeter J. W. B., Mihajlovic M., van Steenbeek F. G., van Wolferen M. E., Oosterhoff L. A., Marsee A., Caiazzo M., van der Laan L. J. W., Penning L. C., Vermonden T., Spee B., Schneeberger K   +12 more
openaire   +7 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Organoids of liver diseases: From bench to bedside [PDF]

World Journal of Gastroenterology, 2019
Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, etc.
Wu, Li-Jun, Chen, Zi-Yan, Wang, Yi, Zhao, Jun-Gang, Xie, Xiao-Zai, Chen, Gang   +5 more
openaire   +2 more sources

Direct Electromembrane Extraction‐Based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids

, 2022
This work introduces a strategy for organoid analysis - direct Electromembrane Extraction based Mass Spectrometry (dEME-MS) – for coupling liver organoids with mass spectrometry (MS).
Aleksandra Aizenshtadt, Bogen, Inger Lise, Jannike Mørch Andersen, Hansen, Frederik André, Pedersen‐bjergaard, Stig, Skottvoll, Frøydis Sved, Krauss, Stefan, Inger Lise Bogen, Jörg P. Kutter, Aizenshtadt, Aleksandra, Andersen, Jannike Mørch, Frederik André Hansen, Stefan Krauss, Elsa Lundanes, Kutter, Jörg P., Mikel Amirola Martinez, Stig Pedersen‐Bjergaard, Steven Ray Wilson, Frøydis Sved Skottvoll, Martinez, Mikel Amirola, Wilson, Steven Ray, Lundanes, Elsa   +21 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids [PDF]

, 2022
Fatty liver disease has grown into a major global health burden, attributed to multi-factors including sedentary lifestyle, obesogenic diet and prevalence of metabolic disorders.
Li, Meng, Cao, Wanlu, Shi, Shaojun, Pan, Qiuwei, Verstegen, Monique M.A., Pan, Qiuwei; id_orcid, Wang, Ling, van der Laan, Luc J.W.; id_orcid, Verstegen, Monique M.A.; id_orcid, Yu, Bingting, Peppelenbosch, Maikel P., Liu, Jiaye, van der Laan, Luc J.W., Ayada, Ibrahim, Zhang, Ruyi   +14 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source