Results 81 to 90 of about 25,342 (266)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology

, 2017
Nuclear receptors (NRs) are ligand-activated transcription factors regulating a large variety of processes involved in reproduction, development, and metabolism. NRs are ideal drug targets because they are activated by lipophilic ligands that easily pass
Lange, Katja, Hooiveld, Guido J. E. J., Milona, Alexandra, Bijsmans, Ingrid T. G. W., Ramos Pittol, José M., Ijssennagger, Noortje, van Mil, Saskia W.C., Willemsen, Ellen C.L., Jonker, Johan W., Pittol, Jose M. Ramos, Jonker, Johan W.; id_orcid, Willemsen, Ellen C. L., van Mil, Saskia W. C., Bijsmans, Ingrid T.G.W., Hooiveld, Guido J.E.J.   +14 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

3D Co-Culture of Hepatocyte, a Hepatic Stellate Cell Line, and Stem Cells for Developing a Bioartificial Liver Prototype

International Journal of Technology, 2020
A liver organoid is an in vitro reconstruction of the liver that mimics the in vivo liver microstructure and performs liver functions. Liver organoids can be used for drug testing, as a model of liver disease pathogenesis, and as a bioartificial ...
Christine Verawaty Sibuea, Jeanne Pawitan, Radiana Antarianto, Cynthia O.M. Jasirwan, Imelda Rosalyn Sianipar, Evah Luviah, Retno Wahyu Nurhayati, Wildan Mubarok, Nuzli Fahdia Mazfufah   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

H&E staining of liver organoids.

, 2018
IHC sections of liver organoids stained with H&E at 4 days post-infection (A-C), 11 days post-infection (D-F), and 18 days post-infection (G-I). Left column pictures (A, D, G) show control organoids, middle column show miR-122 inhibited organoids with ...
Ivy Mead (5537543), Herbert L. Bonkovsky (210820), Meimei Wan (5537540), Colin E. Bishop (126482), Kenneth Koch (5537546), Anthony Atala (88140), Hossein Sendi (5537549), Marjan Mehrab-Mohseni (5141582)   +7 more
core   +1 more source

Liver and bile duct organoids and tumoroids

Biomedicine & Pharmacotherapy
Organoids refer to 3D cultures established to recapitulate histology, pathology, architecture, and genetic traits of various organs and tissues in the body, thereby replacing 2D cell cultures, xenograft, and animal models. Organoids form a 3D in vitro mimic of original tissues like the liver and are derived from embryonic or adult tissue stem cells ...
Xuanming Luo, Yuda Gong, Zijun Gong, Kun Fan, Tao Suo, Han Liu, Xiaoling Ni, Xiaojian Ni, Miyesaier Abudureyimu, Houbao Liu   +9 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential

, 2023
Painted turtles are remarkable for their well-developed freeze tolerance and associated resilience to hypoxia/anoxia, oxidative stress, and ability to supercool.
Kundu, Debosmita, Honold, Sydney, Ralston, Abigail, Topping, Nicholas E., Gessler, Thea B., Allenspach, Karin, Gabriel, Vojtech, Piñeyro, Pablo, Ospina, Oscar, Mochel, Jonathan, Wickham, Hannah, Sifuentes-Romero, Itzel, Sahoo, Dipak Kumar, Tamplin, Jeffrey, Zdyrski, Christopher, Bista, Basanta, Meyerholz, David K., Valenzuela, Nicole   +17 more
core  

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source