Results 71 to 80 of about 25,342 (266)

Liver organoids: a promising three-dimensional model for insights and innovations in tumor progression and precision medicine of liver cancer

Frontiers in Immunology, 2023
Primary liver cancer (PLC) is one type of cancer with high incidence rate and high mortality rate in the worldwide. Systemic therapy is the major treatment for PLC, including surgical resection, immunotherapy and targeted therapy.
Yukun Chen, Yukun Chen, Yujun Liu, Shimin Chen, Long Zhang, Jiawei Rao, Jiawei Rao, Jiawei Rao, Xinjun Lu, Yi Ma, Yi Ma, Yi Ma   +11 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease [PDF]

, 2020
BACKGROUND AND AIMS: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT protein having high ...
Jimenez, Carlos, Gomez-Mariano, Gema Maria, Varela Martinez, Maria del Carmen, Martinez-Delgado, Beatriz, Huch, Meritxell, Garfia, Cristina, Justo, Iago, Janciauskiene, Sabina, Matamala, Nerea, Monzon-Fernandez, Sara, Cuesta de la Plaza, Isabel, Perez de Castro, Ignacio, Posada De la Paz, Manuel, Martinez Rodríguez, Selene, Marcacuzco, Alberto   +14 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Sirius red staining of liver organoids.

, 2018
IHC sections of liver organoids stained with Sirius Red at 4 days post-infection (A-C), 11 days post-infection (D-F), and 18 days post-infection (G-I). Left column pictures (A, D, G) show control organoids, middle column show miR-122 inhibited organoids ...
Ivy Mead (5537543), Herbert L. Bonkovsky (210820), Meimei Wan (5537540), Colin E. Bishop (126482), Kenneth Koch (5537546), Anthony Atala (88140), Hossein Sendi (5537549), Marjan Mehrab-Mohseni (5141582)   +7 more
core   +1 more source

Primary liver cancer organoids and their application to research and therapy

Journal of the National Cancer Center
Primary liver cancer is a leading cause of death worldwide. To create advanced treatments for primary liver cancer, studies have utilized models such as 2D cell culture and in vivo animal models.
Xiaobin Zhu, Rajiv Trehan, Changqing Xie
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction [PDF]

, 2010
The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Greenhough, Sebastian, Medine, Claire N, Hay, David C; id_orcid, Sharma, Ruchi   +3 more
core   +1 more source

Organoids as a model to study intestinal and liver dysfunction in severe malnutrition [PDF]

, 2023
Hospitalized children with severe malnutrition face high mortality rates and often suffer from hepatic and intestinal dysfunction, with negative impacts on their survival.
van Ijzendoorn, Sven C.D., Blokzijl, Tjasso, Martini, Ingrid A., Bourdon, Céline, Bandsma, Robert H.J., Langelaar-Makkinje, Miriam, Bakker, Barbara M.; id_orcid, Versloot, Christian J., Baanstra, Mirjam, Coppes, Robert P., Coppes, Robert P.; id_orcid, Kim, Peter, Gerding, Albert, Langelaar-Makkinje, Miriam; id_orcid, Bakker, Barbara M., Horcas-Nieto, José M., Koster, Mirjam H.   +16 more
core   +1 more source