Results 41 to 50 of about 58,747 (290)
Clinical applications and optimization of patient-derived organoids in intestinal diseases
, 2022 Since the first successful establishment of organoids from adult intestinal stem cells, organoid technology has rapidly developed. With advances in normal organoid technology, intestinal disorders, such as colorectal tumors and inflammatory bowel disease,
Tae Il Kim
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Recent advances in multicellular human liver models [PDF]
Organoid, 2022 The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug ...
Seon Ju Mun +5 more
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Engineered adipose tissue platforms: recent breakthroughs and future perspectives [PDF]
Organoid, 2023 As overweight and obesity rates have increased worldwide, the prevalence of metabolic disorders has also grown. Due to the lack of physiologically relevant adipose tissue platforms, research in adipose tissue biology has relied on animal models, leading ...
Heejeong Yoon, Tae-Eun Park
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Human brain organoids in Alzheimer’s disease
, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that typically involves neuronal damage leading to the deterioration of cognitive and essential body functions in aging brains.
Hansang Cho, You Jung Kang
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Induced pluripotent stem cell-derived hematopoietic stem and progenitor cells: potential, challenges, and future perspectives [PDF]
Organoid, 2023 Hematopoietic stem and progenitor cells (HSPCs) are responsible for the lifetime dynamics of hematopoiesis, as they are well known for their self-renewing ability and multipotency to differentiate into all types of blood cells, including both myeloid and
Myoung Hee Han +2 more
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Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem Cells
Cells, 2020 We developed a novel dentin-pulp-like organoid. It has both stem-cell and odontoblast characteristics using a mesenchymal cell lineage of human dental-pulp stem cells (hDPSCs).
Sang Yun Jeong +5 more
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One-step achievement of tumor spheroid-induced angiogenesis in a high-throughput microfluidic platform: one-step tumor angiogenesis platform [PDF]
Organoid, 2023 Research on the development of anti-cancer drugs has progressed, but the low reliability of animal experiments due to biological differences between animals and humans causes failures in the clinical process.
Seonghyuk Park +6 more
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Genetic engineering in organoids [PDF]
Journal of Molecular Medicine, 2021 AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom +2 more
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
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