Results 41 to 50 of about 67,145 (248)
A novel method for generating induced pluripotent stem cell (iPSC)-derived alveolar organoids: a comparison of their ability depending on iPSC origin [PDF]
, 2023 Background Alveolar organoids may be useful tools in drug discovery for lung diseases, such as chronic obstructive pulmonary disease, and for studying the effects of respiratory viruses, such as severe acute respiratory syndrome coronavirus 2.
Sung-Won Kim, Min Jae Lim, Ayoung Jo
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Development of otic organoids and their current status [PDF]
, 2023 The inner ear is responsible for both hearing and balance in the body, and since the initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) in 2013, significant advances have been made in this field. Bone morphogenetic
Jungho Ha +9 more
core +1 more source
Establishment of functional epithelial organoids from human lacrimal glands
Stem Cell Research & Therapy, 2021 Background Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal tissue; however, the number of ...
Sang Yun Jeong +8 more
doaj +1 more source
Bronchioalveolar organoids as a tool to study transforming growth factor-β and cigarette smoke–induced lung pathology [PDF]
, 2021 Background Respiratory medicine has high barriers to new drug development, with fewer approved new treatments and candidate drugs and a higher failure rate than other common disease fields.
Suji Jeong +3 more
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Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem Cells
Cells, 2020 We developed a novel dentin-pulp-like organoid. It has both stem-cell and odontoblast characteristics using a mesenchymal cell lineage of human dental-pulp stem cells (hDPSCs).
Sang Yun Jeong +5 more
doaj +1 more source
Fetal liver hematopoiesis: from development to delivery
Stem Cell Research & Therapy, 2021 Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability.
Kyle Lewis +2 more
doaj +1 more source
Molecular Autism, 2020 Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available.
Francesca Cavallo +18 more
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Establishment of Pancreatic Organoids from Normal Tissue and Tumors
STAR Protocols, 2020 Summary: Establishment of patient-derived adult stem cell-based pancreatic (tumor) organoids was first described in 2015. Since then, multiple laboratories have demonstrated the robustness of this method.
Else Driehuis +4 more
doaj +1 more source
Scientific ReportsIntroduction Pheochromocytoma (PCC) and paraganglioma (PG) research is limited due to rarity of disease. We utilized patient-derived tumor organoids (PTOs) to explore personalized treatment options for these patients.
Richard A. Erali +9 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source