Results 21 to 30 of about 67,145 (248)
Human brain organoids in Alzheimer’s disease [PDF]
, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that typically involves neuronal damage leading to the deterioration of cognitive and essential body functions in aging brains.
Hansang Cho, You Jung Kang
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Journal of Orthopaedic Translation, 2022 Background: Bone fracture healing is a postnatal regenerative process in which fibrocartilaginous callus formation and bony callus formation are important. Bony callus formation requires osteoblastic differentiation of MSCs.
Fuxiao Wang +9 more
doaj +1 more source
Clinical applications and optimization of patient-derived organoids in intestinal diseases [PDF]
, 2022 Since the first successful establishment of organoids from adult intestinal stem cells, organoid technology has rapidly developed. With advances in normal organoid technology, intestinal disorders, such as colorectal tumors and inflammatory bowel disease,
Tae Il Kim
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Whole Organ Engineering: Approaches, Challenges, and Future Directions
Applied Sciences, 2020 End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage organ failure is organ transplantation.
Sogu Sohn +4 more
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Engineered models for studying blood-brain-barrier-associated brain physiology and pathology [PDF]
Organoid, 2021 The blood-brain barrier (BBB) is a transport barrier that suppresses the translocation of potentially harmful substances to the brain tissue. Although the BBB is known to be associated with many kinds of neuropathology, such as neuroinflammation and ...
Hong Nam Kim
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A novel method for the isolation of CD45-positive and CD45-negative cells from malignant pleural effusion [PDF]
Organoid, 2021 Background Patient-derived malignant pleural effusion (MPE) samples can be used to identify a patient-specific drug combination since MPE samples are readily available and cost-effective tumor cell sources.
Jimin Choi +5 more
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Strategies for vascularization in kidney organoids [PDF]
Organoid, 2022 The establishment of protocols for differentiating kidney organoids from human pluripotent stem cells (hPSCs) has potential for the application of kidney organoids in regenerative medicine. However, the primary obstacle to the regenerative application of
Seo-Yeon Park, Yong Kyun Kim
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Disease modeling in organoid cultures: a new tool for studying viruses [PDF]
, 2022 In vitro experiments have been widely used for more than a century to elucidate molecular mechanisms in cells and pathogen-host interactions, as well as for drug screening.
Eun-Hye Hong, Hyun-Jeong Ko, Jaewon Cho
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Molecular Autism, 2020 The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic ...
Cristina Cheroni +2 more
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