Results 21 to 30 of about 58,747 (290)
Nature Reviews Materials, 2021 Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in culturing physiologically relevant organoids, challenges remain to achieve real-life applications.
Moritz Hofer, Matthias P. Lutolf
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Organoids and Colorectal Cancer [PDF]
Cancers, 2021 Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC)
Antonio Barbáchano +6 more
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Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
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Recent advances and challenges in organoid-on-a-chip technology
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
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, 2021 Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not
Dong-Hun Woo +3 more
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Glioblastoma organoid technology: an emerging preclinical models for drug discovery
, 2022 Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis.
Shuchang Zhou +3 more
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Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
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Progress, prospects, and limitations of organoid technology
, 2022 Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs.
Jung Kyu Choi +2 more
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Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]
Organoid, 2023 Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song +4 more
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