Results 41 to 50 of about 65,212 (162)

Organoid Intelligence: Can We Separate Intelligent Behavior from an Intelligent Being?

Organoids
As brain organoids and organoid-based computational models grow in complexity, they increasingly exhibit electrophysiological patterns consistent with plasticity and information processing.
Daniel Montoya
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Organoide

Medizinrecht, 2020
Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far.
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Evaluation of a Gene Expression-Based Machine Learning Classifier to Discriminate Normal from Cancer Gastric Organoids

Organoids
Three-dimensional cell model systems such as tumour organoids allow for in vitro modelling of self-organized tissue with functional and histologic similarity to in vivo tissue. However, there is a need for standard protocols and techniques to confirm the
Daniel Skubleny, Hasnaien Ahmed, Sebastiao N. Martins-Filho, David Ross McLean, Daniel E. Schiller, Gina R. Rayat   +5 more
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Organoids: Promoting Innovation in Organoid Technology for Basic Research and Therapeutic Applications

Organoids
Over the past decade, organoids representing a wide range of tissues have been developed, with increasing efforts to enhance their complexity, maturity, and resemblance to the corresponding native organs [...]
Süleyman Ergün, Philipp Wörsdörfer
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Organoids as Next-Generation Models for Tumor Heterogeneity, Personalized Therapy, and Cancer Research: Advancements, Applications, and Future Directions

Organoids
Organoid technology has emerged as a revolutionary tool in cancer research, offering physiologically accurate, three-dimensional models that preserve the histoarchitecture, genetic stability, and phenotypic complexity of primary tumors.
Ayush Madan, Ramandeep Saini, Nainci Dhiman, Shu-Hui Juan, Mantosh Kumar Satapathy   +4 more
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High-Throughput Analysis of 3D Cell Culture Oxygen Consumption Using Sensor Arrays: A Novel Platform for Hypoxia/Normoxia Research

Organoids
Precise control and measurement of the cellular microenvironment, particularly oxygen concentration, are crucial for developing physiologically relevant in vitro models.
Christoph Grün, Cordula Nies, Magdalena Klesen, Enja Schwarz, Jonah ter Haseborg, Cornelius Dettmer, Christian Beyer, Larissa Funk, Eric Gottwald   +8 more
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Xenograft-Derived Human Breast Cancer Organoids Can Form Chimeras with Host Mouse Mammary Epithelial Cells Which Promote Tumor Cell Proliferation

Organoids
Breast cancer progression and treatment responsiveness are significantly influenced by the tumor microenvironment. Therefore, transplantation into the mammary fat pad is widely employed to establish a mouse xenograft model of breast cancer.
Hiroyuki Uematsu, Chieko Saito, Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Hiroko Endo, Takahiro Nakayama, Katsuhide Yoshidome, Taisei Nomura, Arihiro Kohara, Masahiro Inoue   +10 more
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Skeletal organoids.

Biomaterials translational
The skeletal system, composed of bones, muscles, joints, ligaments, and tendons, serves as the foundation for maintaining human posture, mobility, and overall biomechanical functionality. However, with ageing, chronic overuse, and acute injuries, conditions such as osteoarthritis, intervertebral disc degeneration, muscle atrophy, and ligament or tendon
Zhang, Chen, Jing, Yingying, Wang, Jianhua, Xia, Zhidao, Lai, Yuxiao, Bai, Long, Su, Jiacan   +6 more
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Organoids: Avatars for Personalized Medicine

The Keio Journal of Medicine, 2019
Stem cells are the foundation of all mammalian life. Stem cells build and maintain our bodies throughout life. Two types of stem cells are discerned.1) Embryonic stem cells (ES cells) are briefly present in the early human or mouse embryo, a few days after fertilization.
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Development of Low-Cost CNC-Milled PMMA Microfluidic Chips as a Prototype for Organ-on-a-Chip and Neurospheroid Applications

Organoids
Improved in vitro models are needed to reduce costs and delays in central nervous system (CNS) drug discovery. The FDA Modernization Acts 2.0 and 3.0 require human-centered alternative testing methods to mitigate animal-based experiments and discovery ...
Sushmita Mishra, Ginia Mondal, Murali Kumarasamy   +2 more
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