Results 51 to 60 of about 106,655 (301)

RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability

Life Science Alliance, 2022
Over the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised medicine. In recent years, several reports hinted at intraculture organoid variability, but a systematic analysis
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro

Organoids
First trimester placental development comprises some of the most critical yet understudied events that impact fetal development. Improper placentation leads to a host of health issues that not only impact the fetal period but also influence offspring ...
Brady M. Wessel, Jenna N. Castro, Victoria H. J. Roberts   +2 more
doaj   +1 more source

Bioengineered tumor organoids

Current Opinion in Biomedical Engineering, 2020
Recent advances in biofabrication technologies, such as cell culture systems, and biomaterials have led to the development of three-dimensional (3D) cell culture platforms, such as tumor organoids. Tumor organoids are more physiologically accurate to the in vivo system, which they are intended to model, compared with traditional 2D cancer cell culture ...
Anthony Dominijanni, Andrea Mazzocchi, Ethan Shelkey, Steven Forsythe, Mahesh Devarsetty, Shay Soker   +5 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Applications for Colon Organoid Models in Cancer Research

Organoids, 2023
Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or disease from which they are derived. Due to their stem cell origin, organoids contain a heterogeneous population of cells reflecting the diversity of cell types
Matthew J. Munro, Swee T. Tan, Clint Gray   +2 more
doaj   +1 more source

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. [PDF]

, 2018
Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration.
Cai, Tao, Dai, Huaping, Huang, Huanwei, Li, Jiao, Li, Juan, Tang, Nan, Tang, Zan, Wang, Fengchao, Wang, Yanjie, Wang, Zheng, Yu, Yuanyuan, Zhang, Chengwei   +11 more
core   +1 more source

Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]

, 2020
Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony, Horii, Mariko, Parast, Mana M, Touma, Ojeni   +3 more
core   +1 more source

Standard: Human intestinal organoids

Cell Regeneration, 2023
AbstractOrganoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.
Yalong Wang, Hanqing Lin, Lianzheng Zhao, Hong Fan, Jie Hao, Zhen Zhang, Weiqi Sheng, Linhong Song, Chu‐Xia Deng, Bing Zhao, Jiani Cao, Lei Wang, Liu Wang, Liping Liang, Wenli Chen, Chunping Yu, Zhian Sun, Yingying Yang, Changlin Wang, Yong Zhang, Qiyuan Li, Ka Li, Aijin Ma, Tongbiao Zhao, Guoqiang Hua, Ye-Guang Chen   +25 more
openaire   +3 more sources