Results 51 to 60 of about 82,310 (303)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Snake venom gland organoids [PDF]

, 2020
Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features of the pertinent epithelium.
Getreuer, W., Kool, J., Iglesias, C.L., Peters, P.J., Ineveld, R.L. van, Richardson, M.K., Bakker, M.A.G. de, Ainsworth, S., Korving, J., Post, Y., Wetering, W.J. van de, Heinz, M.C., Bar-Ephraim, Y.E., Beumer, J., Kerkkamp, H.M., Slagboom, J., Snippert, H.J.G., Rios, A.C., Vonk, F.J., Clevers, H., Kleef, R.G.D.M. van, Barbanson, B. de, Oudenaarden, A. van, Spijkers, X.M., Wevers, N.R., Kazandjian, T.D., Begthel, H., Casewell, N.R., Olivier, T., Westerink, R.H.S., Puschhof, J.   +29 more
core   +2 more sources

Accelerating personalized medicine: miniaturized patient-derived organoid drug screening for predicting cancer treatment responses and beyond

npj Biomedical Innovations
Patient-derived-organoids (PDOs) are valuable tools for predicting individual responses to cancer treatments. However, current screening methods require large numbers of PDOs, resulting in long turnaround times and limiting clinical use. This study aimed
Yasmine Abouleila, Lidwien P. Smabers, Timo Voskuilen, Mayke Doorn, Roel Verkerk, Gakuro Harada, Masahiko Watanabe, Hideaki Kyan, Takahiko Kumagai, Yuichi Hikichi, René Overmeer, Jeanine M. L. Roodhart, Kiyotaka Matsuno, Carla S. Verissimo, Sylvia F. Boj   +14 more
doaj   +1 more source

Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells

Organoids
Tooth and periodontal organoids from stem and progenitor cells represent a significant advancement in regenerative dentistry, offering solutions for tooth loss and periodontal diseases.
Fuad Gandhi Torizal, Syarifah Tiara Noorintan, Zakiya Gania   +2 more
doaj   +1 more source

Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential

, 2023
Painted turtles are remarkable for their well-developed freeze tolerance and associated resilience to hypoxia/anoxia, oxidative stress, and ability to supercool.
Kundu, Debosmita, Honold, Sydney, Ralston, Abigail, Topping, Nicholas E., Gessler, Thea B., Allenspach, Karin, Gabriel, Vojtech, Piñeyro, Pablo, Ospina, Oscar, Mochel, Jonathan, Wickham, Hannah, Sifuentes-Romero, Itzel, Sahoo, Dipak Kumar, Tamplin, Jeffrey, Zdyrski, Christopher, Bista, Basanta, Meyerholz, David K., Valenzuela, Nicole   +17 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design

Organoids
Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the ...
Eyad Awad, Matthew Bedding-Tyrrell, Alberto Coccarelli, Feihu Zhao   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives

Organoids
The development of brain organoids from human-induced pluripotent stem cells (iPSCs) has expanded research into neurodevelopment, disease modeling, and drug testing.
Michael W. Nestor, Richard L. Wilson
doaj   +1 more source

Investigating the role of PAX6 during neurodevelopment using human stem cell-derived brain organoids [PDF]

PAX6 is an evolutionarily conserved transcription factor which acts as a master regulator in the development of the eyes and brain. People with heterozygous mutations in PAX6 suffer from varying levels of optical defects (aniridia) and present with ...
Marshall, Helen
core   +1 more source