Results 51 to 60 of about 65,212 (162)
Organoid Models of Lymphoid Tissues
OrganoidsLymphoid organs are critical for organizing the development of the immune system, generating immune tolerance, and orchestrating the adaptive immune response to foreign antigens.
Ania Bogoslowski +3 more
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Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro
OrganoidsFirst trimester placental development comprises some of the most critical yet understudied events that impact fetal development. Improper placentation leads to a host of health issues that not only impact the fetal period but also influence offspring ...
Brady M. Wessel +2 more
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Regulating organoid and organoid-related activities:
, 2022 This report integrates the two maps produced in WP2 (of the organoid and organ-on-a-chip research and patent landscapes) and WP3 (of the regulatory landscape) of the HYBRIDA Project (Grant Agreement No. 101006012). The result is a multi-dimensional “Super Map,” showing which organoid and organoid-related activities are regulated in which ways and by ...
Lewis, Jonathan, Holm, Søren
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Paneth Cells Are a Constitutive Source of IL-10 in Mouse Small Intestinal Organoids
OrganoidsThe healthy gut masks a dynamic balance between pro- and anti-inflammatory activities, largely due to microbial factors in the lumen. IL-10 is vital among the anti-inflammatory mediators, yet confirming constitutive versus stimulated secretion in any ...
Huong Nguyen +3 more
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Integrating 3D Bioprinting with Organoid Technology-Based Breast Cancer Models for Drug Evaluation
OrganoidsBreast cancer remains one of the leading causes of cancer morbidity and mortality among women worldwide. Conventional two-dimensional (2D) cell culture models and animal studies often fail to accurately recapitulate the complex tumor microenvironment and
Arvind Kumar Shukla +7 more
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AI-Enhanced Patient-Derived Cancer Organoids: Integrating Machine Learning for Precision Oncology
OrganoidsCancer remains a leading cause of mortality worldwide. Patient-derived organoids (PDOs) are three-dimensional (3D) cultures that recapitulate tumor histology, genetics, and cellular heterogeneity, providing physiologically relevant preclinical models ...
Elisa Heinzelmann, Francesco Piraino
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Brain organoids and Ó?organoid intelligenceÓ�: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids. It highlights the potential of these miniaturized, simplified versions of the brain to revolutionize our understanding of neural development, disease mechanisms, and neurophysiology.
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OrganoidsOrganoid and spheroid technologies have rapidly become pivotal in thyroid cancer research, offering models that are more physiologically relevant than traditional two-dimensional culture.
Deepak Gulwani +4 more
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OrganoidsHuman umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess the potential for chondrogenic differentiation, offering a promising alternative source for cartilage regeneration.
Shumaila Khalid +4 more
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Organoid Models: Revolutionizing Disease Modeling and Personalized Therapeutics
OrganoidsAs a three-dimensional in vitro model, organoid technology represents a revolutionary breakthrough in precision medicine. By harnessing the self-organizing capabilities of stem cells within biomimetic extracellular matrices, it enables the generation of ...
Zhifeng Xue +3 more
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