Results 61 to 70 of about 94,019 (259)

Single-Cell Assessment of Human Stem Cell-Derived Mesolimbic Models and Their Responses to Substances of Abuse

Organoids
The mesolimbic pathway connects ventral tegmental area dopaminergic neurons and striatal medium spiny neurons, playing a critical role in reward and stress behaviors.
Thomas P. Rudibaugh, Ryan W. Tam, R. Chris Estridge, Samantha R. Stuppy, Albert J. Keung   +4 more
doaj   +1 more source

Organoids: a systematic review of ethical issues

, 2022
Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen
Bunnik, Eline M., de Jongh, Dide, Massey, Emma K., the VANGUARD consortium   +3 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Organoid Intelligence: Can We Separate Intelligent Behavior from an Intelligent Being?

Organoids
As brain organoids and organoid-based computational models grow in complexity, they increasingly exhibit electrophysiological patterns consistent with plasticity and information processing.
Daniel Montoya
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Evaluation of a Gene Expression-Based Machine Learning Classifier to Discriminate Normal from Cancer Gastric Organoids

Organoids
Three-dimensional cell model systems such as tumour organoids allow for in vitro modelling of self-organized tissue with functional and histologic similarity to in vivo tissue. However, there is a need for standard protocols and techniques to confirm the
Daniel Skubleny, Hasnaien Ahmed, Sebastiao N. Martins-Filho, David Ross McLean, Daniel E. Schiller, Gina R. Rayat   +5 more
doaj   +1 more source

A Practical Guide to Developing and Troubleshooting Patient-Derived “Mini-Gut” Colorectal Organoids for Clinical Research

Patient-derived organoids (PDOs) have emerged as powerful tools in personalized medicine applicable to both non-malignant conditions and to cancer, where they are increasingly used for personalized drug screening and precision treatment strategies in ...
Rex Devasahayam Arokia Balaya, Akhilesh Pandey, Zahra Heydari, Jose M. de Hoyos-Vega, Lisa Boardman, Estela Mariel Cruz Garcia, Alexandra Ros, Lauren Helgeson, Alexander Revzin, Gobinda Sarkar, Eugene Krueger   +10 more
core   +1 more source

Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip [PDF]

Recent advancements in vascular organoid (VO) and vessel-on-chip (VoC) technologies have revolutionized our approach to studying human diseases, offering unprecedented insights through more physiologically relevant models.
Wilson, CV, Gowtham Reddy Cheruku, Chloe Veronica Wilson, Xiao, Q, Qingzhong Xiao, Suriya Raviendran, Cheruku, GR, Raviendran, S   +7 more
core   +1 more source

Organoids in Translational Oncology [PDF]

, 2020
Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out ...
Barbara Zavan, Zavan, Barbara, Caterina Benincasa, Gianrico Spagnuolo, Spagnuolo, Gianrico, De Vito, Danila, Benincasa, Caterina, Makeeva, Irina, Marrelli, Benedetta, Andrea Ballini, Tatullo, Marco, Irina Makeeva, Aiello, Elisabetta, Ballini, Andrea, Danila De Vito, Marco Tatullo, Benedetta Marrelli, Elisabetta Aiello   +17 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source