Results 61 to 70 of about 65,212 (162)
OrganoidsOrganoids consisting of primary human cells, i.e., astrocytes, pericytes, and endothelial cells, form a functional blood–brain barrier (BBB) in vitro.
Kathrin Kostka-Wirtz +3 more
doaj +1 more source
Precision Oncology at a Crossroads: How Organoid Platforms Are Reshaping the Field
OrganoidsTumor heterogeneity and microenvironmental complexity remain fundamental barriers to genomics-centered precision oncology, frequently causing discordance between molecular alterations and real-world therapeutic responses.
Seulbee Lee +9 more
doaj +1 more source
OrganoidsThe intracellular accumulation of amyloid beta 42 (iAβ42) has been proposed as an early pathological indicator of familial Alzheimer’s disease (FAD).
Viviana Soto-Mercado +3 more
doaj +1 more source
3D-Organoid-SwinNet: High-Content Profiling of 3D Organoids
IEEE Journal of Biomedical and Health InformaticsProfiling of Patient-Derived organoids is necessary for drug screening and precision medicine. This step requires accurate segmentation of three-dimensional cellular structures followed by protein readouts. While fully Convolutional Neural Networks are widely used in medical image segmentation, they struggle to capture long-range dependencies necessary
Muhammad Sohaib +3 more
openaire +2 more sources
OrganoidsThe myocardium possesses one of the highest vascular densities in the body. The outermost wall layer of large and medium-sized vessels, the adventitia, forms a critical interface between the vasculature and the myocardium and serves as a reservoir for ...
Hannah Klör +4 more
doaj +1 more source
Evolution of organoid genetics
European Journal of Cell BiologyOrganoids have revolutionized in vitro research by offering three-dimensional, multicellular systems that recapitulate the structure, function, and genetics of human tissues. Initially developed from both pluripotent stem cells (PSCs) and adult stem cells (AdSCs), organoids have expanded to model nearly every major human organ, significantly advancing ...
Thomas M. Klompstra +2 more
openaire +3 more sources
A Pan-Cancer Preclinical Validation Framework for Organoid-Based Drug Sensitivity Testing
OrganoidsPatient-derived organoids (PDOs) provide ex vivo functional models that capture tumor drug-response patterns across multiple cancer types. Organoid drug sensitivity testing (ODST) has accumulated supportive evidence in single-tumor studies, yet it lacks ...
Jia Shang +9 more
doaj +1 more source
OrganoidsTreatment-refractory rectal cancer liver metastasis represents a major therapeutic challenge, particularly in the absence of actionable genomic biomarkers.
Ebrar Tutar-Torun +9 more
doaj +1 more source
Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration
OrganoidsOrganoids present immense promise for studying organ systems and their functionality. Recently, they have become the subject of exploration outside of purely biomedical uses in multiple directions.
Xavier Palmer +4 more
doaj +1 more source