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Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version) [PDF]

Zhongguo aizheng zazhi, 2022
Recently, advances in organoid technology have opened new avenues for the development of novel models of human cancer. Patient-derived tumor organoids retain phenotypes such as histopathological, genetic and molecular features of the original tumor.
The Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association, The Society of Cancer Endocrinology, China Anti-Cancer Association
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Generation of glioblastoma patient-derived organoids and mouse brain orthotopic xenografts for drug screening

STAR Protocols, 2021
Summary: Robust patient-derived platforms that recapitulate the cellular and molecular fingerprints of glioblastoma are crucial for developing effective therapies.
Christian Moya Gamboa, Kelly Jara, Sahithi Pamarthy, Liqiong Liu, Robert Aiken, Zhenggang Xiong, Shabbar Danish, Hatem E. Sabaawy   +7 more
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Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins

Frontiers in Oncology, 2023
The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise characterization.
Kendra D. Marr, Kendra D. Marr, Natalia A. Ignatenko, Noel A. Warfel, Noel A. Warfel, Ken Batai, Anne E. Cress, Anne E. Cress, Grant R. Pollock, Ava C. Wong, Benjamin R. Lee   +10 more
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Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

STAR Protocols, 2022
Summary: Patient-derived tumor organoids can be predictive of patient’s treatment responses, and normal tissue-derived organoids allow for drug toxicity testing.
Camilla Calandrini, Jarno Drost
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Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy

Annals of Medicine, 2022
Propose Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant chemotherapy treatment predicts survival.
Dan Shu, Meiying Shen, Kang Li, Xiaojian Han, Han Li, Zhaofu Tan, Yu Wang, Yang Peng, Zhenrong Tang, Chi Qu, Aishun Jin, Shengchun Liu   +11 more
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Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options.
Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung   +14 more
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Patient-derived organoid (PDO) platforms to facilitate clinical decision making

Journal of Translational Medicine, 2021
Based on recent advances in organoid research as well as the need to find more accurate models for drug screening in cancer research, patient-derived organoids have emerged as an effective in vitro model system to study cancer.
Lisa Liu, Lei Yu, Zhichao Li, Wujiao Li, WeiRen Huang   +4 more
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Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review

Frontiers in Oncology, 2021
Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health.
Ruobing Zhang, Tiantian Guo, Lulin Ji, Yirui Yin, Shuitu Feng, Weihong Lu, Fei Zhang, Maoshu Zhu, Shugang Liu, Jinhua Jiang, Fanwei Zeng   +10 more
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The Role of Patient-Derived Organoids in Triple-Negative Breast Cancer Drug Screening

Biomedicines, 2023
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, with a grave prognosis and few effective treatment options.
Iason Psilopatis, Amalia Mantzari, Kleio Vrettou, Stamatios Theocharis   +3 more
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Establishment of organoids using residual samples from saline flushes during endoscopic ultrasound-guided fine-needle aspiration in patients with pancreatic cancer

Endoscopy International Open, 2022
Background and study aims In patients with pancreatic cancer (PC), patient-derived organoid cultures can be useful tools for personalized drug selection and preclinical evaluation of novel therapies.
Kenji Ikezawa, Tomoya Ekawa, Shinichiro Hasegawa, Yugo Kai, Ryoji Takada, Takuo Yamai, Nobuyasu Fukutake, Hisataka Ogawa, Takashi Akazawa, Yu Mizote, Kumiko Tatsumi, Shigenori Nagata, Kei Asukai, Hidenori Takahashi, Kazuyoshi Ohkawa, Hideaki Tahara   +15 more
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