Results 11 to 20 of about 38,270 (217)

An Organoid-Based Preclinical Model of Human Gastric CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response in individual patients.
Nina G. Steele, Jayati Chakrabarti, Jiang Wang, Jacek Biesiada, Loryn Holokai, Julie Chang, Lauren M. Nowacki, Jennifer Hawkins, Maxime Mahe, Nambirajan Sundaram, Noah Shroyer, Mario Medvedovic, Michael Helmrath, Syed Ahmad, Yana Zavros   +14 more
doaj   +1 more source

Establishment of organoids using residual samples from saline flushes during endoscopic ultrasound-guided fine-needle aspiration in patients with pancreatic cancer

Endoscopy International Open, 2022
Background and study aims In patients with pancreatic cancer (PC), patient-derived organoid cultures can be useful tools for personalized drug selection and preclinical evaluation of novel therapies.
Kenji Ikezawa, Tomoya Ekawa, Shinichiro Hasegawa, Yugo Kai, Ryoji Takada, Takuo Yamai, Nobuyasu Fukutake, Hisataka Ogawa, Takashi Akazawa, Yu Mizote, Kumiko Tatsumi, Shigenori Nagata, Kei Asukai, Hidenori Takahashi, Kazuyoshi Ohkawa, Hideaki Tahara   +15 more
doaj   +1 more source

Patient-derived spheroids and patient-derived organoids simulate evolutions of lung cancer

Heliyon, 2023
Cancer cells harbor many genetic mutations and gene expression profiles different from normal cells. Patient-derived cancer cells (PDCC) are preferred materials in cancer study.
Surina, Tanggis, Tomoko Suzuki, Shu Hisata, Kazutaka Fujita, Satomi Fujiwara, Fangyuan Liu, Noriyoshi Fukushima, Takuji Suzuki, Naoko Mato, Koichi Hagiwara   +10 more
doaj   +1 more source

Application Progress of Organoids in Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2022
Currently, colorectal cancer is still the third leading cause of cancer-related mortality, and the incidence is rising. It is a long time since the researchers used cancer cell lines and animals as the study subject. However, these models possess various
Lianxiang Luo, Lianxiang Luo, Lianxiang Luo, Yucui Ma, Yilin Zheng, Jiating Su, Guoxin Huang   +6 more
doaj   +1 more source

Semi-Automated Computational Assessment of Cancer Organoid Viability Using Rapid Live-Cell Microscopy

Cancer Informatics, 2022
The creation of patient-derived cancer organoids represents a key advance in preclinical modeling and has recently been applied to a variety of human solid tumor types.
Joseph D Buehler, Cylaina E Bird, Milan R Savani, Lauren C Gattie, William H Hicks, Michael M Levitt, Mohamad El Shami, Kimmo J Hatanpaa, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah   +10 more
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Drug discovery via human-derived stem cell organoids

Frontiers in Pharmacology, 2016
Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats.
Fangkun Liu, Fangkun Liu, Jing Huang, Jing Huang, Bo Ning, Zhixiong Liu, Shen Chen, Shen Chen, Wei Zhao, Wei Zhao   +9 more
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Evaluation of chemotherapy drug efficacy using organoids model of colorectal cancer [PDF]

Jichu yixue yu linchuang
Objective To establish human colorectal cancer(CRC) organoids and to evaluate the efficacy of chemotherapy drugs. Methods Patient-derived CRC cells were cultured to form organoids.
GUO Yuehong, ZHOU Fanqi, WU Xi, ZHANG Guannan, WANG Fang, YU Jia
doaj   +1 more source

Generation and characterization of NGLY1 patient-derived midbrain organoids

Frontiers in Cell and Developmental Biology, 2023
NGLY1 deficiency is an ultra-rare, autosomal recessive genetic disease caused by mutations in the NGLY1 gene encoding N-glycanase one that removes N-linked glycan.
Joshua Abbott, Mitali Tambe, Ivan Pavlinov, Atena Farkhondeh, Ha Nam Nguyen, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Tate York, Matthew Might, Karsten Baumgärtel, Steven Rodems, Wei Zheng   +12 more
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Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

BMC Cancer, 2019
Background Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis.
P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito, G. P. Tonini   +13 more
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Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids

Cancer Biology & Medicine, 2021
Objective: Organoids have recently been used as in vitro models to screen chemotherapy drugs in combination with hyperthermia treatment in colorectal cancer.
Lisi Zeng, Quanxing Liao, Haoran Zhao, Shengwei Jiang, Xianzi Yang, Hongsheng Tang, Qingjun He, Xiansheng Yang, Shuxian Fang, Jinfu He, Weiwen Cui, Laiqiang Huang, Shaohua Ma, Shuzhong Cui   +13 more
doaj   +1 more source