Results 81 to 90 of about 82,310 (303)

Evaluation of a Gene Expression-Based Machine Learning Classifier to Discriminate Normal from Cancer Gastric Organoids

Organoids
Three-dimensional cell model systems such as tumour organoids allow for in vitro modelling of self-organized tissue with functional and histologic similarity to in vivo tissue. However, there is a need for standard protocols and techniques to confirm the
Daniel Skubleny, Hasnaien Ahmed, Sebastiao N. Martins-Filho, David Ross McLean, Daniel E. Schiller, Gina R. Rayat   +5 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Organoids: Promoting Innovation in Organoid Technology for Basic Research and Therapeutic Applications

Organoids
Over the past decade, organoids representing a wide range of tissues have been developed, with increasing efforts to enhance their complexity, maturity, and resemblance to the corresponding native organs [...]
Süleyman Ergün, Philipp Wörsdörfer
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Organoids as Next-Generation Models for Tumor Heterogeneity, Personalized Therapy, and Cancer Research: Advancements, Applications, and Future Directions

Organoids
Organoid technology has emerged as a revolutionary tool in cancer research, offering physiologically accurate, three-dimensional models that preserve the histoarchitecture, genetic stability, and phenotypic complexity of primary tumors.
Ayush Madan, Ramandeep Saini, Nainci Dhiman, Shu-Hui Juan, Mantosh Kumar Satapathy   +4 more
doaj   +1 more source

Uncovering Glut-1 Deficiency Syndrome Mechanisms and Therapeutic Targets Using Patient-Derived Brain Organoids [PDF]

Glut-1 Deficiency Syndrome (Glut-1DS) is a rare autosomal dominant neurological disorder caused by heterozygous mutations in the SLC2A1 gene, leading to impaired glucose transport across the blood-brain barrier (BBB).
Isabella Zafferri
core  

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

High-Throughput Analysis of 3D Cell Culture Oxygen Consumption Using Sensor Arrays: A Novel Platform for Hypoxia/Normoxia Research

Organoids
Precise control and measurement of the cellular microenvironment, particularly oxygen concentration, are crucial for developing physiologically relevant in vitro models.
Christoph Grün, Cordula Nies, Magdalena Klesen, Enja Schwarz, Jonah ter Haseborg, Cornelius Dettmer, Christian Beyer, Larissa Funk, Eric Gottwald   +8 more
doaj   +1 more source

Organoids in Translational Oncology [PDF]

, 2020
Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out ...
Barbara Zavan, Zavan, Barbara, Caterina Benincasa, Gianrico Spagnuolo, Spagnuolo, Gianrico, De Vito, Danila, Benincasa, Caterina, Makeeva, Irina, Marrelli, Benedetta, Andrea Ballini, Tatullo, Marco, Irina Makeeva, Aiello, Elisabetta, Ballini, Andrea, Danila De Vito, Marco Tatullo, Benedetta Marrelli, Elisabetta Aiello   +17 more
core   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source