Results 81 to 90 of about 94,019 (259)

From Cells to Microphysiological Systems: 3D Cell Cultures and Organ-on-Chip Systems for Studying cAMP and cGMP Signaling

Organoids
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are key regulators of cellular physiology and tissue homeostasis. Conventional experimental models have provided fundamental insights into cyclic nucleotide pathways; however, they often ...
Maria Rita Assenza, Nicole Bertani, Martina Pinna, Federica Campolo   +3 more
doaj   +1 more source

TISSUE ORGANOIDS [PDF]

, 2023
Physiologically-tailored tissue organoids are disclosed for monitoring and treating diseases and improving an individual's ...

core  

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Brain Organoids, the Path Forward? [PDF]

Photo by Maxim Berg on Unsplash INTRODUCTION The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique.
Ashley Diloreto
core   +3 more sources

Harnessing Bioactive Ceramic for Organoid Engineering: Mechanisms, Applications, and Prospects in Regenerative Medicine

Organoids
Organoids are three-dimensional, stem-cell-derived tissue constructs that recapitulate the architecture and function of native organs, and they have rapidly emerged as transformative tools in regenerative medicine.
Shihan Sun, Sixuan Chen, Wenping Ma, Jun Xu, Mingxia Lu, Hongxu Lu   +5 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Organoid-on-Chip Technologies in Precision Oncology: Bridging Patient-Specific Tumor Biology and Physiologically Relevant Drug Screening

Organoids
The inadequacy of traditional preclinical oncology models, specifically two-dimensional (2D) monolayer cultures and murine in vivo systems, in predicting human drug responses has led to the development of patient-derived organoids (PDOs) and microfluidic
Muhammet Volkan Bulbul, Turan Demircan
doaj   +1 more source

Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations [PDF]

Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (including strokes ...
Kundu, Debosmita, Honold, Sydney, Ralston, Abigail, Topping, Nicholas E., Gessler, Thea B., Allenspach, Karin, Gabriel, Vojtech, Piñeyro, Pablo, Ospina, Oscar, Mochel, Jonathan, Wickham, Hannah, Sifuentes-Romero, Itzel, Galan, Jacob A., Sahoo, Dipak Kumar, Tamplin, Jeffrey, Zdyrski, Christopher, Bista, Basanta, Arriaga, Marco, Meyerholz, David K., Valenzuela, Nicole   +19 more
core  

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Efficient Cryopreservation of Human Midbrain Organoids Using Conventional DMSO Protocols with Ice Recrystallization Inhibitors

Organoids
Human midbrain organoids (hMOs) are a powerful stem cell-derived model for studying human neurodevelopment and neurological disease in vitro; however, their broad adoption is limited by long culture times, high cost, and inter-batch variability ...
Ellyssa M. Walsh, Cecilia Rocha, Paula Lépine, Julien Sirois, Thomas M. Durcan, Robert N. Ben   +5 more
doaj   +1 more source