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Brain organoids: Establishment and application
Frontiers in Cell and Developmental Biology, 2022 Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain,
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
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Brain Organoids and Assembloids—From Disease Modeling to Drug Discovery [PDF]
CellsBrain organoids are self-organized, three-dimensional (3D) aggregates derived from human embryonic stem cells, induced pluripotent stem cells, or primary organs with cell types and cellular architectures resembling those of the developing human brain ...
Aderonke O. Ajongbolo +1 more
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One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids [PDF]
Advanced ScienceHuman‐induced pluripotent stem cell (iPSC)‐derived brain organoids have attracted significant attention as promising models for drug screening owing to their remarkable resemblance to the human brain.
Hyogeun Shin +9 more
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Generation of vascularized brain organoids to study neurovascular interactions
eLife, 2022 Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids.
Xin-Yao Sun +9 more
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Scientific Reports, 2022 The establishment of robust human brain organoids to model cerebellar diseases is essential to study new therapeutic strategies for cerebellum-associated disorders.
João Brás +9 more
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Generation of Human Blood Vessel and Vascularized Cerebral Organoids
Bio-Protocol, 2023 Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun +5 more
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Unraveling Human Brain Development and Evolution Using Organoid Models
Frontiers in Cell and Developmental Biology, 2021 Brain organoids are proving to be physiologically relevant models for studying human brain development in terms of temporal transcriptional signature recapitulation, dynamic cytoarchitectural development, and functional electrophysiological maturation ...
Sarah Fernandes +5 more
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Brain organoids are new tool for drug screening of neurological diseases
Neural Regeneration Research, 2023 At the level of in vitro drug screening, the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening. There are few systematic reports on brain organoids, as
Jin-Qi Zhou +7 more
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Human Brain Organoids to Decode Mechanisms of Microcephaly
Frontiers in Cellular Neuroscience, 2020 Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early events of human brain development. Recent improvements with patient-specific 3D brain organoids have begun to elucidate unprecedented details of the defective ...
Elke Gabriel +3 more
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The Application of Brain Organoids: From Neuronal Development to Neurological Diseases
Frontiers in Cell and Developmental Biology, 2020 Brain organoids are derived from induced pluripotent stem cells and embryonic stem cells under three-dimensional culture condition. The generation of an organoid requires the self-assembly of stem cells, progenitor cells, and multiple types of ...
Yikai Shou +7 more
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