Results 1 to 10 of about 135,862 (166)
Retrotransposons in pluripotent stem cells [PDF]
Cell Regeneration, 2020 AbstractTransposable elements constitute about half of the mammalian genome, and can be divided into two classes: the class I (retrotransposons) and the class II (DNA transposons). A few hundred types of retrotransposons, which are dynamic and stage specific, have been annotated.
Jingwen Wang, Junjiu Huang, Guang Shi
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Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Kang Lan, Gao Shaorong
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iScience, 2022 Summary: Less than 80 Sumatran rhinos (SR, Dicerorhinus sumatrensis) are left on earth. Habitat loss and limited breeding possibilities are the greatest threats to the species and lead to a continuous population decline.
Vera Zywitza +11 more
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Chromatin structure of pluripotent stem cells and induced pluripotent stem cells [PDF]
Briefings in Functional Genomics, 2011 Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors.
Paul, Delgado-Olguín +1 more
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Induced pluripotent stem cells are induced pluripotent stem cell-like cells [PDF]
The Journal of Biomedical Research, 2015 Gold is rare and precious, while pyrite (FeS2) is abundant and cheap. Pyrite is nicknamed fool's gold, since pyrite looks like gold and it is even shinier and brighter than gold. It is very difficult to recognize the differences between a real natural gold and a gold-like rock (pyrite) to non-professional persons[1], but we know that all that glitters ...
Song, Liting, Goldman, Emanuel
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Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction
Scientific Reports, 2022 The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza +21 more
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Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
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miRNA in Pluripotent Stem Cells [PDF]
Regenerative Medicine, 2010 Embryonic stem cells and induced pluripotent stem cells are characterized by their ability to self-renew and differentiate into any cell type. The molecular mechanism behind this process is a complex interplay between the transcriptional factors with epigenetic regulators and signaling pathways.
Uma, Lakshmipathy +2 more
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ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs
STAR Protocols, 2023 Summary: CRISPR-Cas9 technology coupled with human induced pluripotent stem cells allows precise disease modeling in pluripotent cells and subsequently derived specialized cell types.
Katarzyna A. Ludwik +4 more
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Germline and Pluripotent Stem Cells [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Epigenetic mechanisms play an essential role in the germline and imprinting cycle. Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state, which in turn leads to the establishment of pluripotent cells in blastocysts.
Wolf, Reik, M Azim, Surani
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