Transfusion Clinique et Biologique, 2009 The isolation of human embryonic stem cells (ESC) in 1998 has created the hope that stem cells will one day be used to regenerate tissues and organs, even though it is obvious that a number of hurdles will need to be overcome for such therapies to become reality.
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Establishment of pluripotent cell lines from vertebrate species - Present status and future prospects [PDF]
, 1999 Pluripotent embryonic stem (ES) cells are undifferentiated cell lines derived from early embryos and are capable of unlimited undifferentiated proliferation in vitro.
Vassilieva, Svetlana G. +4 more
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Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom +4 more
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A system to enrich for primitive streak-derivatives, definitive endoderm and mesoderm, from pluripotent cells in culture [PDF]
, 2012 Two lineages of endoderm develop during mammalian embryogenesis, the primitive endoderm in the pre-implantation blastocyst and the definitive endoderm at gastrulation.
Lau, KX +27 more
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Germline and Pluripotent Stem Cells [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Epigenetic mechanisms play an essential role in the germline and imprinting cycle. Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state, which in turn leads to the establishment of pluripotent cells in blastocysts.
Wolf, Reik, M Azim, Surani
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Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells [PDF]
, 2009 Stem cells, that is, cells that can both reproduce themselves and differentiate into functional cell types, attract much interest as potential aids to healing and disease therapy. Embryonic neural crest is pluripotent and generates the peripheral nervous
Negulyaev, YA +8 more
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Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells [PDF]
, 2012 Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but their collection is restricted ethically and technically.
Vanleene, Maximilien +55 more
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Pluripotent Stem Cells as a Model for Human Embryogenesis
, 2023 Pluripotent stem cells (PSCs; embryonic stem cells and induced pluripotent stem cells) can recapitulate critical aspects of the early stages of embryonic development; therefore, they became a powerful tool for the in vitro study of molecular mechanisms ...
Mikel Ángel Gidi-Grenat +7 more
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Ibrain, 2022 This study aimed to decipher the effect of glycoprotein nonmetastatic melanoma protein B (GPNMB) on neonatal hypoxic–ischemic encephalopathy (NHIE) and its potential molecular mechanism.
Guo‐Jiao Chen +5 more
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Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]
, 2011 Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco +13 more
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