Results 41 to 50 of about 27,210 (261)

Brain organoid-on-chip system to study the effects of breast cancer derived exosomes on the neurodevelopment of brain

Cell Regeneration, 2022
Early human brain development can be affected by multiple prenatal factors that involve chemical exposures in utero, maternal health characteristics such as psychiatric disorders, and cancer.
Kangli Cui, Wenwen Chen, Rongkai Cao, Yingying Xie, Peng Wang, Yunsong Wu, Yaqing Wang, Jianhua Qin   +7 more
doaj   +1 more source

Applications of organoid technology to brain tumors

CNS Neuroscience & Therapeutics, 2023
AbstractLacking appropriate model impedes basic and preclinical researches of brain tumors. Organoids technology applying on brain tumors enables great recapitulation of the original tumors. Here, we compared brain tumor organoids (BTOs) with common models including cell lines, tumor spheroids, and patient‐derived xenografts.
Jie Wen, Fangkun Liu, Quan Cheng, Nathaniel Weygant, Xisong Liang, Fan Fan, Chuntao Li, Liyang Zhang, Zhixiong Liu   +8 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Modelling Toxoplasma gondii infection in human cerebral organoids

Emerging Microbes and Infections, 2020
Pluripotent stem cell-derived cerebral organoids have the potential to recapitulate the pathophysiology of in vivo human brain tissue, constituting a valuable resource for modelling brain disorders, including infectious diseases.
Hyang-Hee Seo, Hyo-Won Han, Sang-Eun Lee, Sung-Hee Hong, Shin-Hyeong Cho, Sang Cheol Kim, Soo Kyung Koo, Jung-Hyun Kim   +7 more
doaj   +1 more source

Organoid technology for brain and therapeutics research [PDF]

CNS Neuroscience & Therapeutics, 2017
SummaryBrain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders ...
Zhi Wang, Shu‐Na Wang, Tian‐Ying Xu, Zhu‐Wei Miao, Ding‐Feng Su, Chao‐Yu Miao   +5 more
openaire   +2 more sources

The legal personhood of human brain organoids

Journal of Law and the Biosciences, 2023
Abstract Research using three-dimensional neural tissues derived from human pluripotent stem cells—known as ‘human brain organoids’—has progressed rapidly in recent years. Although related ethical issues have been intensively discussed, legal issues have only been sparsely examined compared with the related ethical issues. In this paper,
Masanori Kataoka, Tsung-Ling Lee, Tsutomu Sawai   +2 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids

Frontiers in Cellular Neuroscience, 2021
Human stem cell derived brain organoids are increasingly gaining attention as an ideal model system for investigating neurological diseases, particularly those that involve myelination defects.
Mohammed R. Shaker, Giovanni Pietrogrande, Sally Martin, Sally Martin, Ju-Hyun Lee, Woong Sun, Ernst J. Wolvetang   +6 more
doaj   +1 more source