Results 41 to 50 of about 39,896 (297)

3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

BMC Biomedical Engineering, 2021
Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla, Camilo Salazar-Hernandez, Sally L. Perrin, Kaitlin G. Scheer, Gökhan Cildir, John Toubia, Kristyna Sedivakova, Melinda N. Tea, Sakthi Lenin, Elise Ponthier, Erica C. F. Yeo, Vinay Tergaonkar, Santosh Poonnoose, Rebecca J. Ormsby, Stuart M. Pitson, Michael P. Brown, Lisa M. Ebert, Guillermo A. Gomez   +17 more
doaj   +1 more source

3D organotypic cell structures for drug development and Microorganism-Host interaction research [PDF]

Research Results in Pharmacology, 2021
Introduction: The article describes a new method of tissue engineering, which is based on the use of three-dimensional multicellular constructs consisting of stem cells that mimic the native tissue in vivo – organoids.
Ekaterina V. Zubareva, Sergey V. Nadezhdin, Natalia A. Nadezhdina, Veronika S. Belyaeva, Yuriy E. Burda, Tatyana V. Avtina, Oleg S. Gudyrev, Inga M. Kolesnik, Svetlana Yu. Kulikova, Mikhail O. Mishenin   +9 more
doaj   +3 more sources

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]

, 2019
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana, Asfour, Hani Z., Ding, Yuchun, Doherty, Mary, Dorgau, Birthe, Felemban, Majed, Hallam, Dean, Hilgen, Gerrit, Hunt, Nicola Claire, Kiening, Martin, Krasnogor, Natalio, Lako, Majlinda, Sernagor, Evelyne, White, Kathryn, Whitfield, Phil, Zerti, Darin   +15 more
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Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Frontiers in Immunology, 2022
Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly.
Xuan Su, Xuan Su, Peng Yue, Peng Yue, Jing Kong, Jing Kong, Xin Xu, Xin Xu, Yu Zhang, Yu Zhang, Wenjing Cao, Wenjing Cao, Yuxin Fan, Yuxin Fan, Meixiao Liu, Meixiao Liu, Jingjing Chen, Jingjing Chen, Aihua Liu, Aihua Liu, Fukai Bao, Fukai Bao   +21 more
doaj   +1 more source

Modeling neurological disorders using brain organoids

Seminars in Cell & Developmental Biology, 2021
Neurological disorders are challenging to study given the complexity and species-specific features of the organ system. Brain organoids are three dimensional structured aggregates of neural tissue that are generated by self-organization and differentiation from pluripotent stem cells under optimized culture conditions.
Daniel Y, Zhang, Hongjun, Song, Guo-Li, Ming   +2 more
openaire   +3 more sources

Emerging brain organoids: 3D models to decipher, identify and revolutionize brain

Bioactive Materials
Brain organoids are an emerging in vitro 3D brain model that is integrated from pluripotent stem cells. This model mimics the human brain’s developmental process and disease-related phenotypes to a certain extent while advancing the development of human ...
Yuli Zhao, Ting Wang, Jiajun Liu, Ze Wang, Yuan Lu   +4 more
doaj   +1 more source

Telencephalic organoids as model systems to study cortical development and diseases [PDF]

Organoid
The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete.
Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park   +2 more
doaj   +1 more source

Modeling human neurodevelopmental diseases with brain organoids

Cell Regeneration, 2022
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.
Xiaoxiang Lu, Jiajie Yang, Yangfei Xiang
doaj   +1 more source

Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]

, 2018
Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio, Burclaff, Buzzelli, Caruso, Correa, Correa, Correa, Dai, Degterev, DeLyria, Ding, DiPaolo, DiPaolo, El-Omar, Ferlay, Fox, Ge, Harrington, Hervas-Stubbs, Howlett, Kolls, Landgren, Lennerz, Li, Liao, Machado, McHugh, Merchant, Mills, Moseley, Nam, Nguyen, Nguyen, Nguyen, Nguyen, Onishi, Park, Ramsey, Schumacher, Schwarzenberger, Stummvoll, Varga, Velin, Wada, Yamada, Yamaguchi, Zhang, Zhu   +47 more
core   +3 more sources

Differentiation enhances Zika virus infection of neuronal brain cells. [PDF]

, 2018
Zika virus (ZIKV) is an emerging, mosquito-borne pathogen associated with a widespread 2015-2016 epidemic in the Western Hemisphere and a proven cause of microcephaly and other fetal brain defects in infants born to infected mothers. ZIKV infections have
Bouquet, Jerome, Chiu, Charles Y, Li, Tony, Paranjpe, Aditi, Streithorst, Jessica, Sánchez-San Martín, Claudia, Yu, Guixia   +6 more
core   +3 more sources