Results 41 to 50 of about 2,545,594 (299)

The welfare of brain organoids

Molecular Psychology: Brain, Behavior, and Society, 2023
One of the most urgent challenges arising in bioethics has been the ethical assessment of the use of brain organoids, largely because of the possibility of sentience and the potential that if they can feel, then they might suffer. But while there is a growing literature on the possibility of sentience in brain organoids and why we should take a ...
Heather Browning, Walter Veit
openaire   +1 more source

3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

BMC Biomedical Engineering, 2021
Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla, Camilo Salazar-Hernandez, Sally L. Perrin, Kaitlin G. Scheer, Gökhan Cildir, John Toubia, Kristyna Sedivakova, Melinda N. Tea, Sakthi Lenin, Elise Ponthier, Erica C. F. Yeo, Vinay Tergaonkar, Santosh Poonnoose, Rebecca J. Ormsby, Stuart M. Pitson, Michael P. Brown, Lisa M. Ebert, Guillermo A. Gomez   +17 more
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Vascularized human brain organoids: current possibilities and prospects.

Trends in Biotechnology
Human brain organoids (hBOs) are in vitro, 3D, self-organizing brain tissue structures increasingly used for modeling brain development and disease.
Lois Kistemaker, E. V. van Bodegraven, Helga E. de Vries, E. Hol   +3 more
semanticscholar   +1 more source

Modeling human neurodevelopmental diseases with brain organoids

Cell Regeneration, 2022
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.
Xiaoxiang Lu, Jiajie Yang, Yangfei Xiang
doaj   +1 more source

Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Frontiers in Immunology, 2022
Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly.
Xuan Su, Xuan Su, Peng Yue, Peng Yue, Jing Kong, Jing Kong, Xin Xu, Xin Xu, Yu Zhang, Yu Zhang, Wenjing Cao, Wenjing Cao, Yuxin Fan, Yuxin Fan, Meixiao Liu, Meixiao Liu, Jingjing Chen, Jingjing Chen, Aihua Liu, Aihua Liu, Fukai Bao, Fukai Bao   +21 more
doaj   +1 more source

Magnetically reshapable 3D multi-electrode arrays of liquid metals for electrophysiological analysis of brain organoids

Nature Communications
To comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor the spatiotemporal electrophysiological signals within the organoid, known as intra-organoid signals.
Enji Kim, Eun-Suk Jeong, Yeon-Mi Hong, Inhea Jeong, Junghoon Kim, Yong Won Kwon, Young-Geun Park, Jiin Lee, Suah Choi, Ju-Young Kim, Jae-Hyun Lee, Seung‐Woo Cho, Jang‐Ung Park   +12 more
semanticscholar   +1 more source

An in vivo model of functional and vascularized human brain organoids

Nature Biotechnology, 2018
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease.
A. Mansour, J. Gonçalves, Cooper W Bloyd, Hao Li, Sarah Fernandes, Sarah Fernandes, Daphne Quang, Stephen T. Johnston, Sarah L. Parylak, Xin Jin, F. Gage   +10 more
semanticscholar   +1 more source

Telencephalic organoids as model systems to study cortical development and diseases [PDF]

Organoid
The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete.
Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park   +2 more
doaj   +1 more source

Consciousness and Human Brain Organoids: A Conceptual Mapping of Ethical and Philosophical Literature

AJOB Neuroscience
Human brain organoids (HBOs) are three-dimensional structures derived from human pluripotent stem cells that model aspects of fetal brain development.
Aileen Van Gyseghem, K. Dierickx, A. Barnhart   +2 more
semanticscholar   +1 more source

Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids

Communications Biology
Brain organoid models have greatly facilitated our understanding of human brain development and disease. However, key brain cell types, such as microglia, are lacking in most brain organoid models.
Xianwei Chen, Guoqiang Sun, Lizhao Feng, E. Tian, Yanhong Shi   +4 more
semanticscholar   +1 more source